APL Bioengineering@aplbioeng

A leading open access journal from @AIP_Publishing for the Bioengineering and Biomedical Research Communities EIC: @JustinCooperWh1

pubs.aip.org/aip/apb
Joined September 2022
138 Photos and videos
This review highlights the use of polymer-based drug delivery systems to overcome ocular barriers in retinal diseases, facilitating sustained, targeted, and minimally invasive therapies. Learn more 👇 aippub.org/453fwSv
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Lee et al used a brain-on-a-chip model to show that in Alzheimer’s, toxic tau protein makes brain support cells (astrocytes) overly contract, squeezing vessels and blocking brain waste clearance. Learn more 👇 aippub.org/4eHGqU0

Astrocyte-driven vasoconstriction impairs glymphatic clearance in a human tauopathy-on-chip model

The glymphatic system is a critical pathway for clearing metabolic waste from the brain by mediating cerebrospinal fluid and interstitial fluid exchange. In Alz

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The study uses an organ-chip to reveal how shear stress regulates inflammation in arterial endothelial cells and involvement of primary cilia and YAP as therapeutic targets for atherosclerosis. Learn more 👇 aippub.org/44AczZ7

Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of...

This study describes the development of a microfluidic chip model of the coronary artery endothelium and its use to examine the mechanism through which pulsatil

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We’re continuing the conversation — in a new place. AIP Publishing is now posting on Bluesky: @ aip-publishing.bsky.social Follow us there for the latest research🧪
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We’re continuing the conversation — in a new place. AIP Publishing is now posting on Bluesky: @ aip-publishing.bsky.social Follow us there for the latest research🧪
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Classification of Differentially Activated Groups of Fibroblasts Using Morphodynamic and Motile Features. Learn more 👇 aippub.org/3SG6p4f
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Metronomic photodynamic therapy (mPDT) selectively kills tumor cells by marking them with photosensitizers and applying low-intensity light to induce programmed cell death. #scilight Learn more 👇 aippub.org/4di5kZS

Wireless OLED metronomic photodynamic device kills deep organ tumor cells in rat model

Flexible, implantable diode selectively targets photosensitized rat hepatoma cells with minimal local thermal damage and immune response.

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Cardiac repair is a team effort. This immuno-heart chip explores how cardiac and immune cells interact to influence heart structure and function under stress, advancing in vitro heart repair research. Learn more 👇 aippub.org/3GFcKKw
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A tiny, wire-free light device implanted in the body can now fight deep cancers like liver tumors—offering new hope through gentle, long-term photodynamic therapy. #MedTech, #TranslationalMedicine Learn more 👇 aippub.org/3GztaE4
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We explore cerebellum role in multisensory integration with spiking neural networks that replicated clinical findings, supporting the cerebellum's critical contribution to integrating sensory inputs. Learn more 👇 aippub.org/430eplu
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LFPs recorded 2 days post-stroke predicted 1-month motor recovery in mice. Post-stroke neural activity, particularly from the contralesional hemisphere, was key to accurate outcome prediction. Learn more 👇 aippub.org/43mfYuf

Post-stroke spontaneous motor recovery in mice can be predicted from acute-phase local field...

Stroke remains a leading cause of long-term disability, underscoring the urgent need for effective predictors of motor recovery. Understanding the electrophysio

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Interstitial fluid flow altered T cell egress from an engineered lymph node stroma model regardless of magnitude, while only high magnitude flow induced inflammation and changes to stromal morphology. Learn more 👇 aippub.org/3Z0dhgh
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A wearable PPG-based HRV device harnessing machine learning for real-time stress monitoring enhances mental health care, teletherapy quality, and early mental illness screening. Learn more 👇 aippub.org/4cValqY
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The mechanisms of #CardiogenicPulmonaryEdema, #AcuteRespiratoryDistressSyndrome (#ARDS), and the effects of #PEEP unravelled bya microvascular model of fluid transport in the alveolar septa aippub.org/46I1KVN

Computational pulmonary edema: A microvascular model of alveolar capillary and interstitial flow

We present a microvascular model of fluid transport in the alveolar septa related to pulmonary edema. It consists of a two-dimensional capillary sheet coursing

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Strokes are highly debilitating, affecting millions of people worldwide every year. #scilight Learn more 👇 aippub.org/4jPOqEB

Identifying signs of spontaneous stroke recovery in brain signals

Extracellular brain signals obtained a few days after a stroke could be used to predict the degree of spontaneous recovery a month later.

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The use of #graphenequantumdot in #photothermaltherapy - an effective technology against #cancer - read more below 👇 aippub.org/3YDPwev
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#ICYMI: engineers control cell stemness via 3D micro-fabricated lattice substrate in @APLBioeng paper from @polimi. #stemcells #biomaterials aippub.org/4d6envT

3D photopolymerized microstructured scaffolds influence nuclear deformation, nucleo/cytoskeletal...

Mechanical stimuli from the extracellular environment affect cell morphology and functionality. Recently, we reported that mesenchymal stem cells (MSCs) grown i

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I'm a Survinin! New @APLBioeng paper from @YonghoBae2 and @UB_BME reveals survivin's impact on the modulation of cell phenotype & proliferation. #mechanobiology aippub.org/4dnkNHv

Survivin as a mediator of stiffness-induced cell cycle progression and proliferation of vascular...

Stiffened arteries are a pathology of atherosclerosis, hypertension, and coronary artery disease and a key risk factor for cardiovascular disease events. The in

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Survivin of the fittest! Check out the role of survivin in vascular mechanics and disease @Jacobs_Med_UB #hydrogel, #atherosclerosis, #vascular, #biomechanics aippub.org/3SvoPVO

Survivin regulates intracellular stiffness and extracellular matrix production in vascular smooth...

Vascular dysfunction is a common cause of cardiovascular diseases characterized by the narrowing and stiffening of arteries, such as atherosclerosis, restenosis

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Efficient, cost-effective, and highly tunable molecular engineered DNA microladder-based soft hydrogels - super cool! (@KAUST) #DNA, #hydrogels, #biomaterials, #molecularengineering aippub.org/3WPjScX

Programmable all-DNA hydrogels based on rolling circle and multiprimed chain amplification products

Soft, biocompatible, and tunable materials offer biomedical engineers and material scientists programmable matrices for a variety of biomedical applications. In

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