The Brain and Sleep Research Laboratory is a joint effort of Luisa de Vivo and Michele Bellesi to investigate the neurobiology of sleep and wakefulness
Camerino, Italy
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😴What if part of the connection between sleep and Alzheimer’s disease is hiding in a rhythm of the brain that lasts far longer than a typical brain wave?
Our study in Alzheimer’s & Dementia points to an intriguing candidate: infraslow oscillations of sleep spindle activity.
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The EEG findings also showed relationships with molecular markers.
ISO amplitude showed a trend-level association with the Aβ42/40 ratio, while ISO bandwidth was associated with neurofilament light (NfL) and showed trends involving GFAP and memory retention.
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Overall, these findings suggest that the rhythmic organization of sleep - not just its duration or architecture - may provide a new window into the biology of neurodegeneration in Alzheimer's.
Paper: doi.org/10.1002/alz.71525
Grollero et al., Alzheimer’s & Dementia (2026).
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Physiological brain clearance architecture revealed by neuronal protein tracing: Cell cell.com/cell/fulltext/S0092…
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Quantitative assessment of flow between cerebrospinal and interstitial fluid compartments in humans | PNAS pnas.org/doi/full/10.1073/pn…
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Are infraslow oscillations the missing link between sleep and Alzheimer′s? biorxiv.org/content/10.64898…
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Happy to share our recent work describing a possible role of Locus Coeruleus in the pathophysiology of NREM parasomnias
sciencedirect.com/science/ar…
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Latest piece of the lab. We studied the effects of vestibular stimulation during sleep on synaptic plasticity and motor learning.
Rocking-induced sleep enhancement promotes motor learning through transcriptional and synaptic remodelling
nature.com/articles/s42003-0…
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🧠💤 New lab paper in @PNASNews
Sleep loss doesn’t just make neurons tired - it slows the communication between them.
We show that chronic sleep loss impairs myelin integrity, slows neural signal conduction, and affects cognition & motor behavior.
👉pnas.org/doi/10.1073/pnas.25…
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Sleep is essential for myelin maintenance. Disrupted oligodendrocyte function may underlie cognitive and behavioral impairments after sleep loss.
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🙏 Huge thanks to all co-authors for an amazing collaborative effort!
@Rayila6 @curiousLdV @si_de_santis and others!
@UniCamerino @NeuroAlc @CnrIcb @UnivPoliMarche
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