We are delighted to share the latest findings from the lab in Nature! We report mutation-dependent effects of sleep and exercise on clonal hematopoiesis (CH) and its associated atherosclerosis. nature.com/articles/s41586-0…

Check out our review on modeling the exposome in murine cardiovascular disease! We need to expand holistic whole organism models to study lifestyle and environmental impacts on health to identify evolutionarily selected inter-organ mechanisms that can be therapeutically harnessed

Of the major age-related diseases (cardiovascular, cancer, neurodegenerative) heart is the most preventable with lifestyle factors and medications. It's about to become far more preventable! @Drroxmehran and I teamed up for this @JACCJournals perspective A "once-in-a-generation opportunity" jacc.org/doi/10.1016/j.jacc.…

Officially published @jclinicalinvest - Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes @MoffittNews 🚨 It's not just whether clonal hematopoiesis (CH) is present - it's how it evolves that matters.🚨 jci.org/articles/view/204429

Excited to share our new study @ScienceMagazine by the fantastic Raphael Mattiuz and @jboumelha @SinaiImmunol showing how DC build and sustain tertiary lymphoid structures in cancer. A major step toward enhancing anti-tumor immunity (1/2) science.org/doi/10.1126/scie…

Thought-provoking paper on interactions between genetic risk and exposures/behaviors: nature.com/articles/s41588-0…

My lab is expanding and I am looking for postdocs to join our team! If you are driven to pursue impactful science, have an interest in neuro-cardio-immunology, and want to live in vibrant NYC (with subsidized housing), please reach out! labs.icahn.mssm.edu/mcalpine…

New online! Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis dlvr.it/TT97Xj

We are happy to share another paper from the lab! Led by Lena Gaebel, using unconditioned cell transplant and congenic tracking, we show that Tet2 or Jack2 clonal hematopoiesis do not modify murine tauopathy. journals.sagepub.com/doi/10.…

Nature research paper: Mutation-dependent responses to sleep and exercise in clonal haematopoiesis go.nature.com/4xpf12h

Delighted to contribute to this story now in @Nature led by T. Gerhardt & @cam_phd - In humans & 🐭, exercise and 🛌 showed mutation-specific effects on clonal hematopoiesis, selectively reprogramming mutant cells toward less inflammatory states. nature.com/articles/s41586-0…

OUT NOW | PRESS RELEASE In NEW STUDY, @IcahnMountSinai researchers Teresa Gerhardt, @cam_phd, et al. discovered that moderate-to-vigorous physical activity associated w/ reduced incidence of gene-specific CH & fewer mutant cells in blood. PRESS RELEASE👉 mountsinai.org/about/newsroo…

Blood stem cell mutation clones (CHIP) occur frequently with advanced age and portend risk of cardiovascular disease and cancer. A new report @Nature today tells us about suppression of CHIP by sleep health and exercise in the experimental model and people Data below for exercise, seen in both women and men nature.com/articles/s41586-0…

Delighted to participate in this paper spearheaded by @cam_phd with key human genetics contributions from @mchonig lab! @broadinstitute @MGBResearchNews @harvardmed

Please that @Neuro_Nada's paper in REV-ERBs is out today in @PNASNews. It shows that deletion of REV-ERB alpha & beta unmasks striking phenotypes. REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function | PNAS pnas.org/doi/10.1073/pnas.25…

Now out in @Nature: Biological insights into schizophrenia from ancestrally diverse populations. With @MountSinaiPsych @SinaiBrain @SinaiGenetics @CDNeurogenomics @POPGEM_Lab #MillionVeteranProgram and collaborators across consortia. Read: rdcu.be/eZ7he

This new track for accelerated manuscript publication has been well received! Thank you authors! Please consider JACC: BTS if you have been rejected. Turn a no into a yes, rapidly 👌🏻

🚀2026 IS HERE & The @ScottRussoPhD led #BrainBodyResearchInstitute Seminar Series returns Jan 27th to launch an exciting 2026 season. Join us for cutting-edge talks from leaders in #BrainBody research. See you there! RSVP HERE👉mountsinai.zoom.us/webinar/r…