research.dimensioncap.com/p/… The breakthroughs came from understanding HER2’s abundance, specificity and protein neighborhoods, alongside the biodistribution and internalization of drug candidates. Over the last decade, tools for mapping cell surfaces and tracking molecules have become more powerful and more widely available. In Dimension’s latest research article, “Six Nanometers Apart,” I explore how we can harness these emerging capabilities to repeat HER2’s success at scale and with much greater speed.

Today we're announcing that Modal has crossed $1B in annualized run rate, as well as raised a $750M Series D at a $15.75B valuation, led by @Accel. Since our Series C, usage has tripled and we’ve grown more than 15x year-over-year. We are deeply grateful to the developers and companies building on Modal. There's still so much more to build, and we can't think of a better time to be building software.

AI Drug Discovery Is Becoming a Bottleneck Trade I get excited when an industry starts going through a real regime change. AI drug discovery (“AIDD”) increasingly looks like one of those moments. Two things are happening: 1/ Upstream: the frontier AI labs are piling in. 2/ Downstream: The supply chain is clearly moving. Supply-chain checks suggest the upstream picks-and-shovels of discovery and early preclinical R&D are starting to feel the increase in experimental volume. DNA → protein → assays → sequencing → automation → preclinical testing Names across that stack include $TWST , @GenScript , $ILMN , $TXG , lab-automation vendors and CROs. $TWST expects triple-digit percentage growth in AI-enabled drug-discovery orders in FY26, and another year of triple-digit order growth in FY27. @GenScript's AIDD business doubled YoY in 1H26. Its current platform advertises industrial-scale validation of 4,000+ designs/day, with integrated sequence-to-data workflows. Our channel checks suggest the ramp is moving even faster: roughly 8,000 designs/day currently, with a path toward ~16,000/day by YE26. --- Why does AI drive more wet-lab demand? 1/ AI makes hypothesis generation almost free → way more shots on goal. The bottleneck is moving from expert-driven design to biological validation. 2/ AI models need continuous experimental feedback — and both good and bad data are useful. Traditionally, only the highest-conviction A+ candidates might get pushed into expensive validation. With AI, even the B/C candidates can be valuable because failed experiments generate training data. @GenScript has said its sequence-to-binding workflow can return data in 4–7 days, and that faster cycle times matter because AI models depend on continuous experimental feedback. @Anthropic is a clean example. @claudeai designed 1,320 protein binders. @adaptyvbio converted those digital sequences into DNA, expressed the proteins and tested binding. Only 354 actually bound. And the 966 failures are not wasted. They are useful negative labels: what does not express, what does not bind, what has poor affinity. Those results help train the next model iteration. 3/ Wet labs are no longer just making drugs. They are making training data. $TWST / @GenScript increasingly look like biological data foundries. $TWST explicitly talks about generating model-ready data from AI-designed sequences. In some workflows, the customer may care less about receiving the physical protein than about getting structured experimental results back into the model. Traditional drug discovery asks: “Does candidate X work?” AI drug discovery also asks: “What can this experiment teach the model?” --- TAM of AIDD If AI is simply a better R&D tool, the relevant spending pool is the $300–400B of annual global pharma R&D. If AI meaningfully increases the number of viable drug programs, the opportunity is larger because it expands downstream demand for DNA synthesis, protein production, assays, and preclinical work. Near term, we can also size demand from AI-company spending. If Anthropic reaches $80B of ARR in 2026 and spends just 1% on AIDD, that alone would imply ~$800M of annual investment. --- Trade setup This is a trade that could have long legs. It’s hard to really stop working until PhaseI/II results (2028+) It smells a lot like the bottleneck trade we just saw in semis: GPUs → HBM → networking → power/cooling. In biology, It basically follows the drug discovery process downstream: AI models → designs → DNA/protein → assays → preclinical capacity. After the upstream picks-and-shovels, animal testing could become the next bottleneck. Monkey prices are already near prior highs and CRO capacity is tight. AIDD pushing more candidates into preclinical development would only add demand. ?? But clinical trials are still the bottleneck? This is the biggest pushback I keep coming back to. No matter how fast discovery becomes, drugs still need to go through preclinical → Phase I → Phase II → Phase III → approval. You still need patients, time and capital. But that doesn’t mean the bottleneck trade won’t work. More viable candidates — especially with higher success rates — still means more demand throughout the development process. And who knows: clinical trials themselves may eventually be optimized by AI. ?? What breaks the trade? Near term, the picks-and-shovels trade breaks if experimental budgets stop growing, AI-generated designs don’t translate into useful wet-lab hits, or capacity catches up too quickly. Longer term, the thesis breaks if AI drugs look great in discovery / Phase I but fail at normal rates in Phase II/III. That is why Phase II matters so much. ?? Milestones Late 2026–2027: first Isomorphic-designed drugs enter human trials; more AI-native programs move into IND-enabling work / tox. 2028–2030: clinical trial results start telling us whether AI-designed drugs actually perform better than conventional drugs. Calling all the "bottleneck bros". :) @jukan05 @zephyr_z9 @aleabitoreddit @ParadisLabs +++ More comprehensive analysis: robonomics.substack.com/p/ai…

Our first TPU megakernel for Kimi K3 reaches 709 tokens/s on low-concurrency decode, against 450 tokens/s for our GB200 baseline, both with DSpark speculative decoding. To our knowledge, this is the first TPU inference megakernel. The whole model runs in a single Pallas kernel, and without spec decoding it is roughly 1.4 to 2x the GB200 baseline at batch sizes 1 through 8. We are open sourcing it today. 1/2

Today we’re announcing Darsh Patel has officially joined Dimension. @darsh_cp spent the last 4 years at Bessemer Venture Partners, and will help lead investments across the frontiers of science through to cutting edge compute and infrastructure. Welcome to the team Darsh!!

American business leader Marc Stad has completed a deal to become the controlling owner and largest shareholder of the NBA’s Minnesota Timberwolves and WNBA’s Minnesota Lynx by buying the majority of co-owner Marc Lore’s stake at a $4.5 billion valuation, sources tell ESPN.

Today we’re announcing Lakewatch — a new open, agentic SIEM. Security has changed. Attackers now use agents, operating 24/7 at machine scale, while legacy security tools were built for human-speed threats. We need tools where agents work alongside humans to keep up. Lakewatch brings a new architecture for this agentic era: • Ingest and store all enterprise data, including multimodal sources • Analyze it alongside business data with full governance • Use AI agents to automate detection, investigation, and response Security requires a fundamental platform shift. This is how teams can fight agents with agents. databricks.com/blog/databric…