Evo-devo-cell biologist #liveimaging
Berkeley, CA
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Such a great session - the future of Dev Bio is in great hands!!!
Undergraduate research symposium speakers with session chairs @SocDevBio 2016 Annual Meeting in Las Vegas. Outstanding talks from SDB undergraduate members.
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🎷🎶
Going to #20226SDB @SocDevBio in Vegas? Do you also play jazz? If you’re interested in playing some live jazz with fellow SDB members in Vegas, DM me here
🎹🎺
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BTW, you'll want to click the full screen arrows in the lower right corner to get the full effect (or however full one can get at a measly 1080p).
Early iSOAR 5D movie of membrane and mitochondria dynamics over 3 hrs at 3 min intervals in the head of a zebrafish embryo 6 dpf, covering a 300 x 1000 um FOV at 193 x 193 x 550 nm resolution (0.8 TB total).
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This year there are >70 slots for short talks selected from abstracts for the SDB Annual Meeting. Abstract deadline is April 15 (1 week left!). You must be an SDB member to be selected for a talk. sdbonline.org/2026mtg @SocDevBio @RogersLabUCD @ZebrafishRock @InfoIzfs @SICB_
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Stage-specific transcriptomics of a leader cell reveals cell machineries driving collective invasion
rupress.org/jcb/article/225/…
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True, even a two DOF system can exhibit chaotic behavior, and a single cell is an at least an ~10^7 DOF system (i.e., protein molecules per cell). I still fail to properly convey to others the insane complexity I see in our microscopes, and why successes like AlphaFold only work because of the huge number of unnatural constraints placed on the training data. Case in point (below): lysosome dynamics over 12 min across a 200 x 70 um region in the head of a developing zebrafish embryo, color-coded by depth -- just one of 20k proteins at work.
Our Cell Observatory Initiative is more important than ever, but while we have petabytes of the most mind-blowing data ever, we are still hamstrung by insufficient AI talent and compute -- two resources in great demand everywhere. If anyone can help us over this hurdle, we'd be eternally grateful.
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Grad students & postdocs, it's time to start thinking about applying to the world famous 'Woods Hole' Embryology course @MBLScience It is a transformative experience. Scholarships available. App Deadline Feb 3, 2026. @SocDevBio
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Job offer for fellow microscope builders:
academicjobsonline.org/ajo/j…
Marine Biological Laboratory in Woods Hole is generally a nice place to do research.
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A scientist from UNC Chapel Hill is running for congress in NC for a seat currently held by a republican. If you care about science (and democracy) please consider donating to his campaign
secure.actblue.com/donate/pa…
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Congratulations to senior authors Gokul Upadhyayula and Rui Gao and co-first authors Wei Wang @UIC and Gaoxiang Liu + Xiongtao Ruan @ABCUCBerkeley on imaging axons and myelin sheaths across the entire mouse olfactory bulb in wild type and diseased states. This certainly stress-tested our imaging and data processing pipelines to the utmost "...peak acquisition rates of ~2 tera-voxels per hour over 10 days using nine rounds of interleaved on-block volumetric LLSM imaging and photoslicing...yielded ~0.5 petabytes of raw data", but our MOSAIC microscope (doi.org/10.1101/2025.06.02.6…) and PetaKit5D (doi.org/10.1038/s41592-024-0…) were up to the task.
Thrilled to share our Science cover! VIPS (volumetric imaging via photochemical sectioning) eliminates working-distance limits for whole-mount, nanoscale imaging. LLSM + photodegradable hydrogel + petabyte-scale compute → axons & myelin across mouse olfactory bulbs (WT vs NPC1).
ALT Cover: 3D WT bulb, wedge-out view; VIPS alternates light-sheet imaging & photochemical sectioning.
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Happy that I could play a small part in this before the pandemic and I’m so amazed that 5 years later I’m part of the team!
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out.
biorxiv.org/content/10.1101/…
@Eric_Betzig @legant_lab
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While Gokul for all intents and purposes IS the ABC, I thought he deserves his own shout out, since none of this would have been possible without him: journals.biologists.com/jcs/…
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out.
biorxiv.org/content/10.1101/…
@Eric_Betzig @legant_lab
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🧪 Exciting opportunity! Join the Royer/Jacobo labs @CZBiohub SF! We're seeking a Spatial Molecular Cartography Scientist to push the limits of 3D transcriptomics in zebrafish. Expertise in HCR/FISH techniques wanted! Help us map gene expression at unprecedented detail. #SpatialBiology #JobAlert
job-boards.greenhouse.io/cha…
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#hiring! come join @Eric_Betzig and the rest of an amazing team at the Advanced BioImaging Center at UC Berkeley to help us build the #CellObservatory! 1/2
aprecruit.berkeley.edu/JPF04…
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We are seeking candidates for a fully funded postdoctoral position (3 years) in the Shaner Lab at UCSD. The successful candidate will lead projects focused on genetically encoded biosensor design, validation, and optimization. adc-nice.org/postdoctoral-re…
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Abrupt Dismissal of NIH and NSF Staff Undermines Government Efficiency
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The Society for Developmental Biology has released a statement on the Unprecedented Disruptions to Biomedical Research in the United States.
ALT Scientific research is a driving force behind human progress. It fuels medical breakthroughs, spurs technological innovations and drives economic growth. Federal funding of research by the National Institutes of Health (NIH) and the National Science Foundation (NSF) is absolutely critical for ensuring that the U.S. maintains its global leadership in science and technology. The unprecedented freeze on the review and issuance of federal research grants is already negatively impacting research and could have significant ripple effects. We urge the White House to stop endangering scientific research and allow the NIH and NSF to continue to drive important advances in biomedical research. This is critical for the U.S. to retain its global leadership in scientific advances. Carole LaBonne, PhD, SDB President Ken Cho, PhD, SDB Past President Richard Behringer, PhD, SDB President-Elect
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I’m not on here too much anymore but…
My 85 year old dad is a finalist in a graphic arts contest to design a wine bottle label for his local Maryland winery - if you think his art worthy it would be awesome if you voted for Bernard!
docs.google.com/forms/d/e/1F…
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