Clinical pharmacologist interested in leveraging genetic data to facilitate drug development
London, England
- Tweets 427
- Following 103
- Followers 579
- Likes 1,556
Dipender Gill retweeted
Our review "Integrating genetic data with biological insight: A practical guide to cis-Mendelian randomization" is now published at @AJHGNews - led by @karhunen_v and @BarWoolf with critical insight from @dpsg108 and Pallav Bhatnagar. Thread follows:
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Dipender Gill retweeted
New pre-print "Mendelian randomization in a multi-ancestry world: reflections and practical advice" led by @amymariemason - arxiv.org/abs/2510.17554
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Dipender Gill retweeted
Does lowering blood pressure prevent dementia by reducing Alzheimer’s pathology or by preventing vascular brain injury?
Using MR with a unique postmortem genetic dataset, our new study in ALzheimer's & Dementia supports the latter.
alz-journals.onlinelibrary.w…
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Dipender Gill retweeted
Our multi-population GWAS paper on Afib is online now @NatureComms
We identified more genetic loci, population-specific genetic correlations, improved polygenic risk score, and enhanced risk prediction by integrating a PRS and protein score.
nature.com/articles/s41467-0…
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Dipender Gill retweeted
Current human genetic evidence does not support an adverse effect of lower FXI levels on heart failure risk or cardiovascular function @dpsg108 @iyas_daghlas
ahajrnls.org/4lEadiX
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Dipender Gill retweeted
We conclude that current human genetic evidence does not support an adverse effect of lower FXI levels on heart failure risk or cardiovascular function. Will of course be important to keep an eye on this safety signal in upcoming trials of FXI inhibitors.
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Dipender Gill retweeted
Posting a tad late, but @jamesyrmsk and @dpsg108 and I have a new research letter in @intjepidemiol where we use negative controls to illustrate why drug use phenotypes should not be used as exposures in MR studies academic.oup.com/ije/article…
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Dipender Gill retweeted
Pleased to share our work examining effects of MTHFR missense variants > venous/arterial thromboembolism, & coag cascade proteins - bottom-line: MTHFR missense variants do NOT lead to a hypercoag state; should not be checked as part of hypercoag workups.
pubmed.ncbi.nlm.nih.gov/4020…
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Dipender Gill retweeted
Tons of goodness & insights in our new paper linking the coagulation cascade to ischemic stroke (and subtype) risk using human genetics. A few highlights:
ahajournals.org/doi/10.1161/…
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Dipender Gill retweeted
#STROKE Simultaneous publication at #AANAM 🟢 A large-scale genetic analysis identified circulating coagulation cascade proteins that influence arterial ischemic stroke risk. @iyas_daghlas @dpsg108 @AANmember #AHAJournals ahajrnls.org/4ieWqNO
ALT Graphic abstract in Daghlas et al.
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Dipender Gill retweeted
The MR study by @Yiwen_Liang_99 showed genetically proxied GLP-1R agonism reduced muscle and fat mass but with relatively larger fat mass reduction.Thanks @dpsg108 for co-leading this study
@AprilShanLuo @EricWan_HKU
@HKU_SPH
@hkumed
dom-pubs.pericles-prod.liter…
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Dipender Gill retweeted
Shared genetic factors link adverse pregnancy outcomes (e.g., preeclampsia, GDM) to future CAD risk. Adverse pregnancy outcomes signal underlying susceptibility but don’t directly cause CAD @dpsg108 @TormodRogne ahajournals.org/doi/full/10.…
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Dipender Gill retweeted
Registration is now open for our 2025 Genetics in Drug Development course: onlinesales.admin.cam.ac.uk/…. Details about the course are here: mendelianrandomization.com/i….
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Dipender Gill retweeted
Using proteomics data and comprehensive epidemiological methods, including Mendelian randomization, we prioritize novel proteins implicated in large-artery stiffness jacc.org/doi/10.1016/j.jacbt…
In this #JACCBTS article, authors combine proteomic & genetic analysis to suggest novel roles for several proteins including cartilage intermediate layer protein-2 & neuronal growth factor-1 in large artery stiffness. bit.ly/48Hp6vn
#CVD @DLMann_MD @mariejoedib
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Dipender Gill retweeted
Article Commentary: “LDL-c Lowering, Ischemic Stroke, and Small Vessel Disease Brain Imaging Biomarkers”
In this #BloggingStroke post, Sucharita Ray discusses #Stroke article by @mariejoedib et al. #AHAJournals @dpsg108 @JulioChirinosMd
ahajournals.org/do/10.1161/b…
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Probably the most important paper I will ever write link.springer.com/article/10… @stevesphd @BMCMedicine
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Dipender Gill retweeted
The second article in our most read series is 'Appraisal of the causal effect of plasma caffeine on adiposity, type 2 diabetes, and cardiovascular disease' by @LarssonSC and colleagues.
bit.ly/3Zw17sQ
#bmjmedicine #bmjmmostread
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Dipender Gill retweeted
Co-localisation and cis-#MendelianRandomization provide genetic evidence for targeting IL-2, IL-6 and TYK2 signalling in prevention of type 1 #diabetes @karhunen_v @dpsg108 #T1D #DiabetesResearch tinyurl.com/44kwru35 🔓
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Dipender Gill retweeted
Drug Target Mendelian Randomization in Non-European Ancestry Groups: The Example of Lipid-Lowering Drug Targets
In this #BloggingStroke post, @B_Rioux discusses #Stroke article by Soremekun et al. #AHAJournals @dpsg108 @Sfatumo @glosh92731
ahajrnls.org/3ZuibU4
ALT Graphic abstract in Soremekun et al.
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Dipender Gill retweeted
New manuscript "Addressing the credibility crisis in Mendelian randomization" is out at @BMCMedicine: bmcmedicine.biomedcentral.co…. We discuss the explosion in MR studies, and what can be done by authors and editors/reviewers to improve the quality of published MR research. Thread:
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