Shouldn't we Audit the Cancer Society? 100 years and $100Billion in donations but still no cure?

JUST IN: First Lady Melania Trump announces a new executive order focused on advancing women's health, calling it a "transformative moment for women in America." "Beginning today, we will change the reality of women's health." The first lady says the focus is shifting from the fight for women's rights to the search for cures that could help women live healthier, fuller lives.

I find that AI assisted science has deeply increased my joy and curiosity, and rather than using this new ability to pump out slop I aspire to publish much less, of a much higher quality. Maybe others will feel the same. 🤷‍♂️

The people closest to AI and who went on to start the labs or become doomers are among the most accurate about capabilities. (Along with non doomers like Kurzweil and Andrew Ng.) But their accuracy on societal impacts has been pretty poor. They understand AI better than they understand the world it exists in. In addition, AI doomer scenarios like AI 2027 have now diverged from actual observations by almost two orders of magnitude. The real world is much messier than benchmarks or projections.

Just published @TheLancet Global threats to health in the 21st century an opus, 59 page comprehensive dissection of all the threats we face thelancet.com/journals/lance… @IHME_UW

If we want to unlock biological engineering we need to kill the manual lab bench. I've tried almost everything else over the last 20 years😛and PhDs still having to be in the lab is the rate limiter.

Mathematics is the paradigm of "works or doesn't work."

In my view, the right response by the mathematical community to OpenAI’s papers is to say: “We’re not accepting these papers as finished work. It’s not our job to sit down and read your model-generated proofs. It is your job to present your work through presentations and convince people of the correctness of your work. It’s always the case that whoever makes a claim needs to provide sufficient explanation and evidence to make independent verification feasible. Until that moment, you just have a claim.” There’s a difference between a proof being mathematically correct and a proof being accepted as correct by the mathematical community. Mathematical truth doesn't depend on consensus, but scientific recognition requires scrutiny, communication, and reproducibility. They're still the arbiters of whether anyone's claims, including OpenAI's, are accepted as valid, and they should leverage that to the maximum extent possible.

Hundreds of human tRNA genes form a redundant repertoire for decoding the genetic code. But does redundancy imply functional equivalence? A pan-cancer in vivo CRISPRi atlas from @genophoria and Vijay Ramani at @GladstoneInst reveals a structured landscape of tRNA dependencies.

I'm working on a "what is a woman" piece, speaking with geneticists, etc. I hope to finish soon. Scientists I've spoken with repeatedly told me the sex binary is incredibly overly simplified, that genetic variation at the chromosomal level is real. Should we not report that?

They will not self-reform. Total ideological capture is the point. Adjust accordingly.

Ok, this is incredible. A new classical Catholic high school just opened in Fairfax County (St. Jerome Institute) — this is what a serious education looks like: – Phones collected at the door – Every class is a seminar discussion – 15-20 students seated facing one another – Art and music are required, NOT elective – Math class teaches "the intrinsic beauty of math" – Entire curriculum is integrated: philosophical and theological questioning in every class And here's the literature section of the reading list: 9th grade (Exodus & Odyssey): – Homer, Odyssey – Genesis – Plato, Euthyphro and Apology – Virgil, Aeneid – Exodus – Beowulf – Song of Roland – Gospel of Luke – Plato, Phaedo and Crito – Acts of the Apostles – Hemingway, The Old Man and the Sea – Wilder, Our Town 10th grade (God & Nature): – Creation myths – Plato, Timaeus and Symposium – Aristotle, De Anima – Plotinus – Augustine, Gregory of Nyssa, Bonaventure, Aquinas – Sir Gawain and the Green Knight – Shakespeare, A Midsummer Night’s Dream – Descartes, Meditations – Bacon, Newton, Darwin – Berry, Wilder, Tolkien – Tocqueville – Benedict XVI – Cather, Death Comes for the Archbishop – Faulkner, The Bear 11th grade (God & the Human Person): – Sophocles, Oedipus Rex – Plato, Symposium – Aristotle, Nicomachean Ethics – Augustine, Confessions – Shakespeare, Twelfth Night and King Lear – Hobbes, Leviathan – Swift, A Modest Proposal – Austen, Pride and Prejudice – Shelley, Frankenstein – Hopkins – O’Connor – Martin Luther King Jr. – Dostoevsky, Crime and Punishment – John Paul II 12th grade (God & Society): – Plato, Republic – Dante, The Divine Comedy – Aristotle, Politics – Augustine, City of God – Aquinas, De Regno – Natural and human law – Machiavelli, Hobbes – Locke, Rousseau – Marx and Engels – Dignitatis Humanae, Evangelium Vitae, Centesimus Annus – John Courtney Murray – Leviticus – Dostoevsky, The Brothers Karamazov – The Declaration of Independence – The Constitution – The Federalist Papers "They gain an in-depth knowledge of Western civilization from Athens, Rome, and Jerusalem through England and the founding of our own country."