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I learned a ton while working with @brainevodevo @KlkUmut and @GrayCampLab on a review article covering the genetic basis of human-specific traits 🧵
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We propose that a Great Ape Cell Atlas (GACA) and an iPSC repository for great apes would be extremely beneficial to the field, but that these would need to be constructed in an ethical manner.
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It will be exciting if some of our predictions come true in the next decade; it will be even more fun to read about advances that we never saw coming. It is an exciting time to be studying the genetic basis of human-specific traits! nature.com/articles/s41576-0…
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Craig Lowe retweeted
I'm thrilled to see the first paper from our lab, the main paper of my graduate work, published today and featured on the cover at Cell @CellCellPress!
cell.com/cell/fulltext/S0092…
ALT This week's cover at Cell, depicting DNA helices in the style of Lascaux cave art.
ALT The cover page for our article out today in Cell, titled "Adaptive sequence divergence forged new neurodevelpmental enhancers in humans".
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We show that the fastest-evolved regions of the human genome - human ancestor quickly evolved regions or “HAQERS” (pronounced like “hackers”) - not only have locally fast mutation rates, but are also creating lots of adaptive variants 🧵
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HAQERs are also enriched for disease-linked variation, suggesting an active role in shaping human-specific susceptibilities to disease.
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Get the full story from our new publication in Cell:
cell.com/cell/fulltext/S0092…
@riley_mangan @TheSilverLab @DukeGenomics @DukeGCB @DukeMGM
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Are the most divergent regions in the human genome caused by locally high mutation rates in functionless DNA or the result of positive selection? Turns out, it’s both!
@vertgenlab @theSilverLab Reddy Lab (lead author: @riley_mangan) 🧵