PhD candidate | Montana State University | Genetic conflict | Structural biology
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Selfish genes rock!!! Click on the link to find out why. Thanks to all my coauthors for being incredible mentors. @WiedenheftLab @HarmitMalik @janet_young_123 @artemnemudryi @ANemudraia oup2-idp.sams-sigma.com/auth…
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Very happy our paper on Zorya anti-phage defense system is now published in
@Nature! 🥳 Big congrats to first authors
@HaidaiHu and @__jphilipp and all other authors! Wonderful collab with @Salmo_Lab
and @SimonJacksonNZ #cryoEM @UCPH_CPR @koebenhavns_uni nature.com/articles/s41586-0…
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Free scientific illustrations for biologists! 😍
@NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations!
all freely available in the public domain.
Retweet and spread the message!
bioart.niaid.nih.gov/
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Some thoughts on the current state of single particle cryo-EM map/model validation. (TLDR: preferred orientation remains a big problem, ❤️ Q-scores. There's been progress, but there's still more to do. ) authors.elsevier.com/sd/arti…
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My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses.
(👇 I recommend sound ON for the video 🎹)
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I’m excited to share my 1st postdoc paper! The thread below summarizes the main findings of our study. biorxiv.org/content/10.1101/…
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Our story on RNA-templated gene synthesis in antiviral immunity is out today in @ScienceMagazine! We discovered a cryptic gene, neo, that is created de novo by infected cells in a remarkable feat of molecular gymnastics🤸
science.org/doi/10.1126/scie…
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Also, check out this parallel publication by Burman et al., who identified how phages can escape PARIS immunity and discovered the tRNA targeted by the PARIS system. Congrats!!!
nature.com/articles/s41586-0…
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Out today in @Nature!
I am thrilled to share our work on the PARIS immune system in its final published form. Huge thanks to my mentor, Kevin Corbett @_KevinCorbett, and my teammates.
See the thread below in comment section for a quick summary!
nature.com/articles/s41586-0…
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Crafted with ❤️ for the scientific community and totally open-source! Don't hesitate to get in contact.
We are happy to announce the public release of EMhub, a web platform designed to support the operations of a scientific facility, enabling easy management of users, instruments, bookings, and project tracking. EMhub was unveiled at the #ACA2024 last week by @delarosatrevin
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Nature research paper: TnpB homologues exapted from transposons are RNA-guided transcription factors go.nature.com/4eETtFu
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New activity on the Chan Zuckerberg Imaging Institute’s CryoET Data Portal bit.ly/3T9sZ6D ; segmentations can now be visualized in the browser for 15,000+ tomograms. We would love feedback bit.ly/3VUcHjc on how we can improve and expand.
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I am delighted to share the latest preprint from our lab, which was work that was conceived and led by @JTenthorey during her postdoc and during the first few months of her independent lab at UCSF.
biorxiv.org/content/10.1101/…
TL;DR: Indels matter. A lot.
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Ancient viral genes repurposed for functions in mammalian reproduction. 🤯
Super excited to see this up on bioRxiv. Very grateful to be a part of this collaboration!
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Montana State scientists’ research on RNA editing illuminates possible lifesaving treatments for genetic diseases
montana.edu/news/23722/monta…
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We show that CRISPR-guided RNA breaks are repaired in human transcripts, and we leverage this process to make programmable RNA excisions that restore gene function.
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Nemudryi lab will open in September of 2024 at @UFMedicine!
We will use programmable ribonucleases to study how human cells repair RNA and how RNA viruses co-opt these mechanisms for their benefit.
Interested? Get in touch!
nemudryi-lab.com
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New article from @henriques_will @janet_young_123 @artemnemudryi @ANemudraia @WiedenheftLab @HarmitMalik: The Diverse Evolutionary Histories of Domesticated Metaviral Capsid Genes in Mammals buff.ly/3U5QZX7 #science #evolution #biology #genome
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Cellular repair of DNA breaks enables editing of the human genome.
Do human cells repair RNA breaks, and can we use it to edit transcriptomes?
Our work with @ANemudraia and @WiedenheftLab is now online in @ScienceMagazine!
#ScienceResearch
science.org/doi/10.1126/scie…
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That amazing paper you spent years on? That amazing breakthrough you had? Very likely you built this following the work of others (very few exceptions), just as others will build off yours. Science is a continuum. Want to leave a lasting legacy in science? Be generous & be kind.
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