We aim at identifying mechanisms of cancer pathogenesis to develop novel mechanism-based and molecular-informed cancer therapies
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- Following 93
- Followers 122
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Keller-Lab@Charite retweeted
💡Möglicher neuer Ansatz gegen #Bauchspeicheldrüsenkrebs: Wie eine #CharitéBerlin-Studie jetzt zeigt, führt die gleichzeitige Blockade zweier voneinander abhängiger „Zahnrädchen“ in der Krebszelle zur Hemmung des Tumorwachstums – zumindest im Tiermodell.👉charite.de/forschung/paper_s…
ALT Tumor der Bauchspeicheldrüse nach Kombinationsbehandlung. Sie bewirkt, dass die Fresszellen des Immunsystems (Makrophagen; gelb) nicht mehr das Tumorwachstum fördern, sondern seine Bekämpfung durch das Immunsystem stimulieren © Charité | Zuzana Tatarova
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Early View | Haematologica haematologica.org/article/vi…
Finally first results from our Phase 1 TCR study targeting MAGE-A1 in myeloma!
Hopefully more to come in advanced solid tumors where need for innovative (cellular) therapies is still HUGE.
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Teclistamab-Induced Remission in Refractory Systemic Lupus Erythematosus | New England Journal of Medicine nejm.org/doi/full/10.1056/NE…
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Keller-Lab@Charite retweeted
Engineering a mouse model of #autoimmunity, researchers at @ChariteBerlin have made strides in understanding the basis of a mysterious and rare autoimmune disorder named STAT3GOF syndrome and identified sex-specific differences in the disorder. @lab_keller scim.ag/60n
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Keller-Lab@Charite retweeted
Researchers generated a new mouse model of #STAT3GOF syndrome that can recapitulate the IL-6-gp130-STAT3 pathway and multi-organ autoimmunity—addressing the lack of reliable animal models for this rare autoimmune condition. @lab_keller @ChariteBerlin scim.ag/5Xp
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Check out our recent publication in EMBO Mol Med:
Actionable loss of SLF2 drives B-cell lymphomagenesis and impairs the DNA damage response
embopress.org/doi/full/10.15…
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Great opprtunity for a postdoctoral researcher/team leader at Keller-Lab@Charite
karriere.charite.de/stellena…
Looking forward to your application!
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We are looking for a talented PhD student. See our announcement at Charité Homepage and Jobvector!
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Keller-Lab@Charite retweeted
In Annals of Oncology, results from the German 🇩🇪 #PrecisionMedicine 🧬🎯💊 NCT/DKTK MASTER trial inform on the association of cancer perdisposing genes and rare cancer
annalsofoncology.org/article…
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Keller-Lab@Charite retweeted
Dr. Uta Demel von #CharitéBerlin und @MDC_Berlin ist für eine ihrer Publikationen mit dem Forschungspreis der Arbeitsgemeinschaft DAG-HSZT ausgezeichnet worden. Herzlichen Glückwunsch! charite.de/forschung/themen_…
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Keller-Lab@Charite retweeted
It's not all about #ubiquitin: Listen to Uta Demel from @lab_keller @MDC_Berlin how inhibition of SUMOylation leads to increased antigen presentation and T-cell activation
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Keller-Lab@Charite retweeted
A team of researchers from #CharitéBerlin reveal in @jclinicalinvest how cancer cells can evade immunosurveillance. A cellular signaling pathway activated as part of this process may offer a new target for more effective cancer immunotherapy treatments. jci.org/articles/view/152383
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Keller-Lab@Charite retweeted
New treatment strategy for #PancreaticCancer: Writing in @PNASNews, a team of researchers from #CharitéBerlin describe how a key factor which enables the suppression of cancer cell death (#apoptosis) can be used to block #TumorGrowth. charite.de/en/service/press_…
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Keller-Lab@Charite retweeted
Writing in @NatureComms, a team of researchers from #CharitéBerlin and @goetheuni untangle a key process involved in #Lymphoma development, which controls DNA damage repair and offers a potential treatment target. charite.de/en/service/press_…
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Richie, Stefan and coworkers reveal a critical role for CXCR4 in aggressive forms of CLL :
nature.com/articles/s41375-0…
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Keller-Lab@Charite retweeted
After years of hard work (literally) involving blood, sweat and tears, I am thrilled to be able share this! We developed TCRs targeting one of the most common mutations in #lymphoma. Online at @jitcancer : jitc.bmj.com/content/9/7/e00…
@MDC_Berlin @ChariteBerlin
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Important preclinical study to advance tumor-specific adoptive T cell therapy for patients with MYD88 mutant lymphoma. Congratulations to Antonia Busses group jitc.bmj.com/content/9/7/e00…
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Keller-Lab@Charite retweeted
Sorry, für heute muss ich erst einmal weg. Ich bin echt enttäuscht und fassungslos zugleich. Mit Beleidigungen kann ich umgehen, aber einige Wortmeldungen sind für mich echt harter Tobak.
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Keller-Lab@Charite retweeted
After 20 years of preliminary research in the labs of @MDC_Berlin & #CharitéBerlin, a new T-cell immunotherapy against #MultipleMyeloma is now in clinical trials. The innovative treatment is designed to teach the immune system to fight the cancer cells. charite.de/en/service/press_…
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