PhD in Neuroscience, now Postdoc in Bathellier's lab. In vivo electrophysiology and all-optical circuit interrogation. Also, love climbing, cycling and running!
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I'll be attending #SfN2023! I'll be presenting preliminary results collected since I started my postdoc in @BathellierL! Is 2P all-optical ephys coming soon? Come check my poster (PSTR275.18/CC14) on Mon 13 afternoon (1-5PM)!!
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Matteo Pisoni retweeted
We finally achieved a dream I had 10 years ago: sustained (>30 min) deep-tissue (>400 um deep) imaging of fast voltage dynamics (e.g., spikes in bursts) in the brains of awake behaving mice. See our paper in *Cell* here: doi.org/10.1016/j.cell.2022.…
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Matteo Pisoni retweeted
Our paper reporting the first natural light-gated potassium-selective channelrhodopsins (KCRs) was published yesterday in Nature Neuroscience. nature.com/articles/s41593-0…. The study was led by senior author John Spudich and first author Elena Govorunova.
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Matteo Pisoni retweeted
A new piece of knowledge on the mechanism underlying memory consolidation during sleep! Thanks @AimeMattia @Tidis__, great working with you!
Hot off the press - Congrats @AimeMattia Niccolo @tmcampelo and all co-authors, so proud of you. Paradoxical somatodendritic decoupling supports cortical plasticity during REM sleep. Thx to @ERC_Research @snsf_ch @inselgruppe science.org/doi/10.1126/scie…
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Matteo Pisoni retweeted
Now in Nature Protocols!
rdcu.be/cMeO2
Workflow for all-optical interrogation experiments w/setup & calibration of microscope (including how to choose a photostim laser & stim strategy and avoid photodamage), sample prep & characterisation, and putting it all together!
So you want to try an all-optical interrogation experiment, but are daunted by the complexity? Then this preprint is for you! It provides a detailed guide to designing and executing experiments using simultaneous 2-photon optogenetics and 2-photon imaging: biorxiv.org/content/10.1101/…
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Matteo Pisoni retweeted
CITE-On on @NatureComms!
A CNN-based algo trained to perform fast automatic neural segmentation, tracking, and trace extraction in 2p Ca imaging data!
CITE-On generalizes across Ca indicators, brain regions, acquisition params, works offline or online! nature.com/articles/s41467-0…
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Matteo Pisoni retweeted
In the latest issue! The structure of a pump-like channelrhodopsin reveals design principles and enables the creation of faster optogenetic tools
#structuralbiology #sciencetwitter
@KarlDeisseroth @Stanford
bit.ly/3rUK9ai
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Matteo Pisoni retweeted
Our first research work is out in @naturemethods!
Huge thanks to ALL collaborators & funders who made this work possible including Tyagarajan + Weber Labs @UZH_IPT @UZH_en @ETH Burdakov Lab @FellinLab @TidisLab @NadineGogolla @MiriamStoeber @ERC_Research @ProjectDeeper @SNSF_ch
OxLight1 from the @tpatriarchi lab is a genetically encoded sensor for orexin neuropeptides. The sensor works in fiber photometry recordings and two-photon imaging as shown in mice during a variety of behaviors.
@UZH_ch #biosensors #neuropeptides
OA paper: nature.com/articles/s41592-0…
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