Professor of Chemistry and Biochemistry at the University of California, Los Angeles. Passionate about Science & Art!
Los Angeles, CA
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Want to know everything about #ArtificialIntelligence, #DeepLearning, and #CompChem to study and engineer #GeneEditing systems — from #CRISPR-Cas proteins to base and prime editors, and #RNA Guided Transposons?
Check out our new piece in @NatureSMB !
nature.com/articles/s41594-0…
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Congratulations to the 2027 Theory & Computation subgroup awardees!! 🎉 @BiophysicalSoc
Mid Career: Anđela Šarić; Early Career: @smnlssn; Postdocs: Chelsea Brown and Mohammad Ahsan 🎉 Sponsored by the Chicago Center for Theoretical Chemistry & PRXlife.
We're very happy to announce the 2027 Theory & Computation subgroup awardees!! 🎉 @BiophysicalSoc Mid Career: Anđela Šarić; Early Career: @smnlssn ; Postdocs: Chelsea Brown and Mohammad Ahsan 🎉 Sponsored by the Chicago Center for Theoretical Chemistry & PRXlife.
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🚀Excited to share our new paper @NatureComms🎉!
We uncover a 🧨 #CrypticPocket in #CRISPR #Cas9 that forms transiently on super short timescales not trapped by #cryoEM!
🧬This pocket enables metal ions to regulate #DNA cleavage!
#compchem #NMR
🔗 nature.com/articles/s41467-0…
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🧨🥵🥵Don’t miss the deadline for the @BiophysicalSoc Theory & Computation Awards Sept 15! 🥵🥵🚀
The award will recognize outstanding Postdocs, Early Career and Mid-Career scientists in the field of computational biophysics.
biophysics.org/Awards-Fundin…
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Last but not least, tomorrow #ACSFall2026 🧬
🚀 #AI-driven #FreeEnergy + #ProteinDesign + #GraphNeuralNetworks to design improved and more precise #BaseEditing - the next generation #PrecisionMedicine.
⏰ 10:40–10:55 AM📍Room S106a
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Tomorrow #ACSFAll2026:
⏰ 10:40–11:15 AM📍Room W184bc
Join us for exciting science!
Interpretable #AI, causal inference, and molecular simulations can reveal the mechanisms underlying #RNA-guided transposition in #CRISPR associated Transposons!
Paper: doi.org/10.1021/jacs.6c05500
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Tomorrow #ACSFall2026
⏰ 08:00–08:20 AM📍Room W181a
Dr. Chinmai Pindi from my lab will also talk about the design rules to expand PAM targeting capabilities in #CRISPR systems.
#chemcomp #moleculardynamics #proteindesign
📖📚Paper @NatureSMB
doi.org/10.1038/s41594-025-0…
Thursday at #ACSFall2026: 1 of 5
Chinmai Pindi (Postdoctoral Scholar – Palermo group) presents “Design rules for expanding PAM compatibility in CRISPR-Cas9 from molecular mechanics and causation inference.”
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Tomorrow #ACSFall2026 ⏰ 10:55–11:10 AM📷 Room S106a Dr. Chinmai Pindi presents her work on the mechanism of TnsC filament assembly on free DNA in CRISPR-associated transposons. Just published
@J_A_C_S
#CRISPR #RNA #DeepLearning #AI #MolecularSimulations #ComputationalBiophysics
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🚀🧨Want to use interpretable #ArtificialIntelligence to analyze #MolecularDynamics simulations and uncover molecular mechanisms?
Our Graph Attention Network (GAT) code presented #ACSFAll2026 is available!
🌟🌟🌟 SCAN THE QR CODE 🌟🌟🌟
#CompChem
@J_A_C_S: doi.org/10.1021/jacs.6c05500
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Following my talk, for those interested in applying causal inference to #MolecularDynamics simulations, here is our code for Granger causality analysis.
🌟SCAN the QR CODE
#ACSFall2026 #CompChem
paper @J_A_C_S
doi.org/10.1021/jacs.6c05500
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🧨First talk from our lab #ACSFall2026 tomorrow! Don’t miss it if you want to know more about interpretable #ArtificialIntelligence in #compchem! With application on #RNA-guided #DNA transposition! More talks will come !!!
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🌟🎉Happy to share this Review @NatRevMCB written in collaboration with @davidwtaylorjr !
Cas12a continues to be one of the most versatile #CRISPR systems, with transformative applications in #GeneEditing & diagnostics.
nature.com/articles/s41580-0…
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🌟Send us your most exciting science on #MolecularDynamics, #CompChem, #Biophysics, #AIforScience to celebrate together the pioneering work of Andy McCammon!🎉🍾
🏹Submit for this special issue in @BiophysJ on #Protein Dynamics: cell.com/biophysj/authors
💌 Info: BJ@biophysics.org
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Amazing protein design by @kellogg_liz lab!
Amazing work from the Kellogg lab!! I had this kind of project in my very first 2022 professorship proposal and but never actually did it, super glad to see it can work in reality!!!
biorxiv.org/content/10.64898…
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Excited to participate in the @ProteinSociety webinar on Friday, May 29 (12–2 PM EST)! proteinsociety.org/webinars
I’ll present our newest methods #AI-enhanced #MolecularDynamics, #NeuralNetworks, and #DeepLearning to uncover #CRISPR #GeneEditing and #RNA-guided transposition!
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Looking forward to join outstanding speakers whose work has advanced the discovery of #crypticPockets and fundamental mechanisms of #allostery through #simulations, #NMR, and experimental biophysics.
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Excited to co-organize the @KeystoneSymp on Integrative Structural Biology with Alex De Marco @NYSBC_Science and Niccolò Banterle @EMBLHeidelberg!
⭐️Stellar speakers & keynote by @fraser_lab @UCSF!
keystonesymposia.org/confere…
RETWEET&APPLY
#KSStructuralBio27 #CryoEM #AI #Compchem
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Our new Cas12a review article with @davidwtaylorjr lab is out @NatRevMCB ! This was great collaboration between @aakashsahha, and the Taylor lab members
@jacquelyn_wrong and @fregoso_ocampo!
nature.com/articles/s41580-0…
Check out our new Cas12a review article with @palermo_lab! Great work by graduate students @jacquelyn_wrong and @fregoso_ocampo @TexasScience @ut_mbs! nature.com/articles/s41580-0…
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