Postdoctoral researcher (@ContraCancerEs) at @unisevilla. Former @EMBO & @CIRMnews fellow at @UCIrvine. Cellular Stress Signaling and Poly(ADP-ribose) biology.
Seville, Spain
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Our latest study from my postdoctoral work has just been published in @ScienceAdvances.
Grateful to my mentor and collaborators who made it possible! @RemiBuisson @ElodieBournique @AmbrocioSanchz @UCIrvine @abbygreenlab @J_Maciejowski
🔗 science.org/doi/10.1126/scia…
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PARP1 directly disassembles nucleosomes to regulate DNA repair: Molecular Cell cell.com/molecular-cell/full…
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🧬¡Ya tenemos el cartel completo del nuevo ciclo de seminarios CABIMER 2026-2027!
Tendremos ponentes invitados de instituciones de referencia en Europa y EE.UU., nos visitarán cada viernes a las 12h para compartir su investigación en biología molecular y medicina regenerativa.
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Hypertranscription caused by p53 deficiency triggers nucleotide insufficiency that induces replication stress and genomic instability dlvr.it/TVMbHs
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Uncovering the structure-function relationship of a lncRNA critical for genomic stability —still much to learn, but a big step forward! Incredible collaboration with @FMorenoHerrero @OscarLlorcaCNIO @ChillonIsabel & supported by @FundlaCaixa.
Online Now: CONCR lncRNA organizes a 3′-end structural domain that engages DDX11 for DNA replication and sister chromatid cohesion dlvr.it/TVD6XG
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A few months ago I was browsing google images looking at p53 western blots in the SK-OV-3 cell line for an unrelated project. I noticed an unusual western blot hosted on Thermo Fisher's website which I posted on social media. Usually I just post weird blots to PubPeer. 👇
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Zinc increases stress granule formation by promoting RNA condensation: Cell Reports cell.com/cell-reports/fullte…
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Final Version of Record published
Nuclear speckle-associated perispeckle networks partition active chromatin into gene expression niches: Cell Reports cell.com/cell-reports/fullte…
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Great talk last Friday at #CABDseminars by @pedroorteg! Pedro told us about his past and future scientific projects. Pedro was hosted by Peter Askjaer
Thanks for coming!
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I am happy to share the good news of a new Publication from our lab. Many thanks to Maxi, the Team and the great collaborators!!!
Manipulation of protein translation and stem cell self-renewal by CRISPR activation of rRNA transcription | Science science.org/doi/10.1126/scie…
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#CABDseminars
"From DNA Damage to Translation Shutdown" by Pedro Ortega @pedroorteg , @cabimer
🗓️ July 17th
⏰12 pm
📍Rosalind Franklin Auditorium, CABD
Hosted by Peter Askjaer
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Very excited to announce the workshop "DNA–Protein Crosslinks: Mechanisms and Links to Rare Genetic Disorders", which will take place in Baeza (Spain) from 18–20 November 2026! unia.es/estudios-y-acceso/of…
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First-ever meeting on "DNA-Protein Crosslinks" in genome instability and disease. Superb line-up of speakers awaits. Send your abstract today and join us for an engaging discussion! Please RT!!
📆 Nov 18-20th 2026
📍 Baeza, Andalucia, Spain
unia.es/estudios-y-acceso/of…
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🧬 New work showing that PARP1 trapping activates ATM-mediated NF-κB signaling independently of DNA replication during TOP1 blockade.
Glad to have contributed to this study from @RemiBuisson @UCIrvine.
doi.org/10.1093/nar/gkag561
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Thrilled to share our latest preprint biorxiv.org/content/10.64898…. In this study, we identified EXO1 as a clinically relevant, targetable candidate in Ewing sarcoma.
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🔬¿Eres postdoc e investigas en cáncer?
ESTE JUEVES‼️
📅4JUN
⏰12h
➡️"Acreditación ANECA y certificado R3: claves para avanzar en la carrera académica"
📢@ElisaEspinet y @AcUcero
✅Coordinan S. Manzano y @GandulloLucia de ASEICA-Postdoc
📩aseicapostdocs@gmail.com
#ASEICAJoven
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New preprint from Josefine Striepen and team on APOBEC3A regulation in cancer.
We find that rare, transient squamous-state excursions activate APOBEC3A, potentially explaining how brief cell-state transitions drive APOBEC mutagenesis.
bit.ly/42VHsab
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Excited to share our collaborative work with the @TonyMustoe and @SuperSciJew labs, led by the fearless @RitwikaBose15.
In this study, we developed RAID-MAP, an approach to map RNA structure within biomolecular condensates in living cells.
biorxiv.org/content/10.64898…
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INSTALLing recombinase-driven genome writing: Engineered single-stranded donors bypass innate immunity to enable large DNA integration dlvr.it/TSjbpV
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Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)
cell.com/cell/fulltext/S0092…
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🔥 A new study from our lab, led by star student @LVSoles, reveals splicing and 3′ processing aren't just coordinated — they're actively competing. Disrupting splicing (via U1, U2, U2AF, SF3b) unleashes thousands of intronic polyadenylation sites and triggers widespread premature transcription termination. 🧬 #RNAbiology #Transcription
The competition between splicing and 3′ processing shapes the human transcriptome
genesdev.cshlp.org/cgi/conte…
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