$xncr interesting data. ORR pretty good but pooled pfs based on the swimmer plot seems to imply median pfs between 5-7 months. This is similar to currently available agents in the 3rd and 4th line.
$rvmd In order for current competitors to gain market share vs rvmd, they must be able to conclusively demonstrate that either their drugs are better or they work in patients with resistance. This is what pfe did with 5 year alk data to catch Roche.
$rvmd$incy$vstm Looking at g12d inhibitors today reminds me of egfr space 10 years ago. At that time you had azd9291 and co-1686, with egf816 and hanmi slightly behind. Az turned out to have the best drug, moved quickly and totally dominated the class. Rvmd appears similar
$abvx A few times I can recall phase 3 trials have had cancer imbalances that were entirely by luck. I’m sure most remember the ocrevus breast signal. Another less well known example is veozah. In both cases no black box because the preclinical was clean
Would $vktx trade higher if it were a tirzepatide biosimilar? $3B ev when $lly selling $50B plus??? Do people think they get less than 1% market share with same or better drug?
$MRK FDA adds "pericardial effusion" to Winrevair adverse reactions and requires enhanced pharmacovigilance program. Recall, this adverse reaction killed $KROS as a potential competitor.