James Murphy@pseudokinase

Biochemist. Scientifically interested in kinases, pseudokinases/zombie proteins and signal transduction. All Blacks and Crusaders fan. He/him

 Melbourne
Joined April 2011
267 Photos and videos
James Murphy retweeted
Andre Samson@AndreSamson15
Aug 28
Thrilled to share our work! science.org/doi/10.1126/scie… Patients can look well-controlled and still have epithelial death programs running. We found it in nascent IBD lesions on advanced therapy and it flagged who relapsed over 2–3 years. @WEHI_research @NHMRC #ScienceResearch

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Although current therapies aim to...

science.org
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Great to see this out. Congrats to our wonderful team
WEHI (Walter and Eliza Hall Institute)@WEHI_research
Aug 27
Uncovered: early molecular warning signs of inflammatory bowel disease reveal the condition can begin before symptoms appear and continue silently even when patients appear well. Published in @ScienceMagazine. 🔗wehi.edu.au/news/researchers…
Image taken through spatial transcriptomics showing patterns of cell death-related genes in gut tissue from people with inflammatory bowel disease. The headline reads "The 'smouldering' defect behind inflammatory bowel disease flare-ups"

ALT Image taken through spatial transcriptomics showing patterns of cell death-related genes in gut tissue from people with inflammatory bowel disease. The headline reads "The 'smouldering' defect behind inflammatory bowel disease flare-ups"
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Are you interested in the underlying molecular mechanisms of life? Explore the latest completed issue of the Biochemical Journal which delves into the newest developments in this exciting area! ow.ly/3JiA50Wi4Qc
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James Murphy retweeted
IUBMB@iubmb
25 May 2025
With less than a month to submit abstracts for the IUBMB Focused Meeting on (pseudo)Kinases in stunning Queenstown—we are delighted to announce travel scholarships for selected ECRs thanks to The Company of Biologists and Maurice and Phyllis Paykel Trust! bit.ly/4dCSKVg
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James Murphy retweeted
Tier 2 Rugby
@T2Rugby
24 Feb 2025
🇳🇱 Rugby Nederland instagram contrasts the size of big lock Koen Bloemen and little scrum half Boris Hadinegoro to try and illustrate the sport as for all sizes.
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We officially declare that Iceland II (New Zealand), the land of fire and ice down south, are going to win the Champions Trophy of 2025. No pressure.
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WEHI & @MIPS_Australia uncover kinase PSKH1 regulation! @pseudokinase @ChrisH_NZ + team found PSKH1’s activity changes with protein interactions and calcium levels. Findings that could lead to new treatments for cancer + other diseases. wehi.edu.au/news/scientists-…
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James Murphy retweeted
BanffSNCC@BanffSNCC
18 Feb 2025
📢 Last chance to register! The 13th SNCC Conference in Banff is approaching—register by Feb 23 to secure your spot! 🔗 event.fourwaves.com/banffsnc… #SNCC2025 #Banff #ScientificConference
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Tremendous to see this out today. Thanks to all the collaborators far and wide and the study’s co-pilots @ChrisH_NZ and @Dr_CaMKkinase
Monash Institute of Pharmaceutical Sciences@MIPS_Australia
19 Feb 2025
New discovery: Researchers from @MIPS_Australia and @WEHI_research have discovered how to “switch off” a molecule which is among the top culprits behind prostate cancer, and is also linked to lung and kidney cancers. Published overnight in @PNASNews
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James Murphy retweeted
Hanadi Hoblos@HanadiHoblos
7 Feb 2025
Glad to share my cover art for the Feb 2025 issue of @TrendsBiochem. Check out our review in "Protein shapeshifting in necroptotic cell death signalling" with @pseudokinase @AndreSamson15 and Wayne Cawthorne cell.com/trends/biochemical-…
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James Murphy retweeted
BanffSNCC@BanffSNCC
20 Jan 2025
🗻 Join us at the 2025 Banff Conference on Signaling in Normal and Cancer Cells! 🗓️ March 23–27, 2025 📍 @banffcentre 🔬Register now: event.fourwaves.com/banffsnc… Let’s push the boundaries of science together! #SNCCBanff #SNCCBanff2025
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If you are visiting UConn Health this month, get a cup of coffee and walk by my science-inspired art exhibit in the main building! @uconnhealth @UConn @UConnResearch #sciart
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James Murphy retweeted
IUBMB@iubmb
3 Jan 2025
Our December Newsletter highlights IUBMB activities including a note from the President and updates on the IUBMB Trainee Initiative 🔗bit.ly/3DQRNuv
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James Murphy retweeted
Hanadi Hoblos@HanadiHoblos
3 Jan 2025
Glad to see this out😄 With Wayne Cawthorne, @AndreSamson15 & @pseudokinase Looking forward to seeing more discoveries of how PTMs regulate protein shapeshifting during necroptotic cell death ☠️ Check it out here 👇 doi.org/10.1016/j.tibs.2024.…
Trends in Biochemical Sciences@TrendsBiochem
2 Jan 2025
Available online - the Review "Protein shapeshifting in #necroptotic cell death signaling" from @pseudokinase and colleagues. #programmedcelldeath #kinase #pseudokinase #phosphorylation #proteinconformation Read it here 👉 authors.elsevier.com/a/1kKdt…
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Available online - the Review "Protein shapeshifting in #necroptotic cell death signaling" from @pseudokinase and colleagues. #programmedcelldeath #kinase #pseudokinase #phosphorylation #proteinconformation Read it here 👉 authors.elsevier.com/a/1kKdt…
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We understand that fast dissemination of your work is essential. This is why our Production team work tirelessly to get accepted papers out into the community, with a median acceptance to publication time of 17 days across our journals. portlandpress.com/biochemj
Benefits of publishing with us. Across our journals the median acceptance to publication is 17 days.

ALT Benefits of publishing with us. Across our journals the median acceptance to publication is 17 days.
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James Murphy retweeted
Daniel Hurdiss@DanielHurdiss
27 Dec 2024
I’m looking for a postdoc to join my team under a recently funded ERC Starting Grant. If you’re passionate about structural #virology and have experience in #cryoEM SPA and/or #cryoET, get in touch! Deadline: January 19th. Please share 🙏 tiny.cc/7v33001
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This perspective from Oldham and Mabbitt explores our growing understanding of the plant Arg/N-degron pathway, highlighting the latest research on E3 ligases. #OA doi.org/10.1042/BCJ20240132
Amino acid sequence alignment of the ZZ-domains of PRT1 (UniProt accession number Q8LBL5) and P62 (UniProt accession number Q13501). Putative zinc coordinating residues are in bold. Residues in p62 and PRT1 that are involved in substrate recognition are indicated.

ALT Amino acid sequence alignment of the ZZ-domains of PRT1 (UniProt accession number Q8LBL5) and P62 (UniProt accession number Q13501). Putative zinc coordinating residues are in bold. Residues in p62 and PRT1 that are involved in substrate recognition are indicated.

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James Murphy retweeted
BanffSNCC@BanffSNCC
20 Dec 2024
🔬 CALL FOR ABSTRACTS: Banff 2025 – Signaling in Normal and Cancer Cells 🔗 Submit your abstract here: event.fourwaves.com/banffsnc… ⏳ Deadline for submissions: Feb. 28, 2025 @CostinAntonescu @BiochemSoc @tfri_research @marathonofhope @pseudokinase
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James Murphy retweeted
Clare Weeden@DrClareWeeden
19 Dec 2024
I am looking for a research assistant to join my new lab in Melbourne, Australia at WEHI. Please apply at the link below! tinyurl.com/4wkt2jve
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