On August 31, the first two participants were injected with @PopVaxIndia’s first fridge-stable RNA vaccine candidate in a Phase I clinical trial in Australia. We built this vaccine at our RNA Foundry in Hyderabad – from computational design to GMP manufacturing. Here's how:

Kiran and her team developed India's first novel cancer therapies two decades ago -- we're honoured to be following in their footsteps!

I am ridiculously excited to watch this!

Launching RNAFoundry.com – we manufacture personalized cancer vaccines.

No offence but can we get a walkable footpath in juhu before we get a floating billboard

Go talk to Siddhant!

Japanese chipmaker Rapidus was founded in August 2022, and by mid 2025, they had a 2nm process working on a pilot line. Worried by India’s lack of compute sovereignty, I asked a professor of mine why we couldn’t replicate this effort- he answered with one word - Talent. Japan has been working with semiconductors since basically the invention of the transistor- consequently they’ve developed individual and organisational knowhow and tacit knowledge on how to build this industry - this looks like individual engineers knowing how to optimise a dose matrix, identify lithographic defects, figure out which step led to a bad IV curve- but also organisations as a whole having the knowhow and discipline on how to make ultrapure chemicals, how to decontaminate a part and how to install and maintain equipment. To develop the talent you need the ecosystem that can train the knowhow, and to develop the ecosystem you need the talent- this is a chicken and egg problem. In August 2025, we started @hackerfabindia and have been building open source equipment to fabricate semiconductors. Simultaneously, @itsarnavb and @_lagrangepoint have been working on discovering and nurturing talent all over the country. Arnav and I sat down a couple of months ago, and brainstormed how we can solve this chicken and egg problem - and Junction is the fruit of that discussion. We will bring the best and brightest builders from colleges all over the country under one roof, and equip them with funding and mentorship from experts in academia and the industry. The idea is to get the hands-on knowledge, context and confidence by building small projects now- to go on to building big, frontier projects in the industry. We hope for Junction to spring up many chapters of HackerFab all over the country - centres which will mirror this ethos of learning by building- while being linked to India’s larger semiconductor mission. If India in 2026 can start building a pipeline producing the best semiconductor talent - it’s exciting to think about where that gets us 10-15 years from now. The journey from sand to superintelligence is driven by talent, and Junction is where talent comes together. The current in a PN junction diode takes off exponentially once the threshold voltage is crossed -- the journey for India’s Semiconductor Mission to cross its threshold is a challenging one. Join and help us catalyse it!

Incredibly exciting project from my friends at @_lagrangepoint and @hackerfabindia -- if you're interested in building chips, sign up!

Exciting stuff from Viswa and his team @enveda! If you're working at the intersection of chemistry, biology, and machine learning, consider joining the challenge!

“If we can predict the [protein's] shape, we can design a drug that recognizes the harmful form and leaves the healthy one alone.” A Hopkins-led team backed by up to $52M from @ARPA_H will build an AI model to decode how proteins misfold in Parkinson’s, cancer, and other diseases. bit.ly/4zMyCdb

Despite staggering advances in basic science, drug development research is only getting slower. The main culprit? Increasing clinical trial timelines. The median clinical development pathway has increased from 8.4 years to 9.3 years and pipeline creation has slowed 32% even as R&D spend has gone up. This is the point I keep making about the main bottleneck to drug discovery and why AI on its own won't be enough. These timelines aren't going anywhere (ofc AI can be used creatively to ease such bottlenecks -- eg via better endpoints that allow smaller cohorts for trials, followed up for shorter periods of time).

Working on the vaccines part of this @PopVaxIndia supported in large part by Vitalik and Balvi, and would strongly recommend others jump in and work in all of these areas as well!

Part 1: I profile @PopVaxIndia and @sohamsankaran’s ambitious work on making first in class mRNA vaccines, personalised cancer therapies and AI biosecurity out of Hyd, for the world: (DM for gift link) livemint.com/companies/start…

@iskander and I are hiring a senior experimental scientist to work with us on our project funded by Open AI Foundation to discover tumor antigens, tumor antigen-associated T cell receptors, and assess TCR performance via functional studies of TCR-engineered T cells. Apply here ( unc.peopleadmin.com/postings… ) if interested!

Going for a walk in India often feels like a video game. On the footpath you're dodging: - Holes - Hoardings - Construction - Electrical boxes And when you finally give up and hit the road you're brushing shoulders with autos, wrong-side drivers, buses and water tankers.

It is true. Neal Stephenson will be on the Core Memory podcast this week, and we will be digging into space, AI, swords, BCIs, the nature of reality and his new book

Very cool stuff!

One of Samarth's most intriguing ideas -- we've been talking about it for months. Well worth the read!