ALT First cochlear targeting results using low-titer H2B-GFP lentivirus. Injections performed at embryonic day 8, collection at postnatal day 0. Hair cells shown in magenta, GFP-labelled cells shown in green. DAPI (nuclei) in blue

ALT Figure 1 Modelling CySCs in the Drosophila testis. (A) Schematic of the GSC and CySC niche. GSCs (pink) and CySCs (green) touching the hub (blue cells) have access to pro-self-renewing signals and maintain stemness. CySCs not in contact with the hub lose access to pro-self-renewing signals and become licensed for differentiation, although they require active signalling to differentiate. To form a cyst, two CySC daughters surround one GSC daughter (or gonialblast). These co-differentiate, whereby the CySC daughters become post-mitotic cyst cells, while the germ cell progresses through spermatogonial divisions. (B) Schematic of the four reactions considered in the SL model.