Excited to welcome Orchestra Bio and @ashokaraj_ to OpenAI as we broaden our work in AI-assisted drug discovery!

Four years ago to the day, we started Orchestra Bio to help biotech and pharma teams advance their drug development programs. AI has now reached an inflection point where people and agents can take this on together. Today, we’re thrilled to share that Orchestra Bio is joining OpenAI to continue our mission at an even greater scale.

We’ve acquired Orchestra Bio, a platform that helps biopharma teams coordinate the complex process of drug development. Together, we’ll build on Rosalind, our AI models and tools for life sciences research, to streamline those operations and help new treatments reach patients sooner. Welcome @ashokaraj_ and team! openai.com/index/openai-to-a…

We started Arda in 2025 to speed up American manufacturing. We have spent the last year building with Anduril as our design partner. Today we are launching the company publicly on CNBC and announcing our Series A: $160M at a $1.5B valuation. Our platform helps manufacturers design and operate manual assembly lines, putting designs into production faster now. Next we'll build automated lines that can be reconfigured as quickly as human workers, letting America make products that now require armies of workers in Asia.

Today, Ramp raised $1.85B at a $60B valuation. Seven years ago, Karim and I wrote our mission on a Post-it: “Save companies time and money.” Our mission hasn't changed. It’s just gotten bigger.

Today we're announcing that Modal has crossed $1B in annualized run rate, as well as raised a $750M Series D at a $15.75B valuation, led by @Accel. Since our Series C, usage has tripled and we’ve grown more than 15x year-over-year. We are deeply grateful to the developers and companies building on Modal. There's still so much more to build, and we can't think of a better time to be building software.

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Native customer service in Instinct Nobody likes talking to customer service. Instinct should handle those tasks for you. With Instinct Concierge, we enabled Instinct to make calls on your behalf. Now, we’re taking this a step further. When your Instinct connects with participating businesses on @SierraPlatform and @DecagonAI, the agents will be able to work together to solve your problem with speed, reliability, and safety without making a phone call. I’m excited to announce that Instinct will be partnering with Sierra and Decagon to bring customer service experiences directly to your personal agent. Customer service tasks like: - Troubleshooting your home wifi issues - Finding out when a delayed package will arrive - Figuring out why your bill is higher than last month - Getting clarity on a confusing return or cancellation policy

We’re thrilled to welcome Chris Degnan as our Chief Revenue Officer to help us scale globally and build the future of software. Chris joined Snowflake as its first sales hire. Over the next decade, he scaled alongside the company and grew into Snowflake’s CRO, driving over $3B in ARR and building one of the most iconic sales organizations in tech. He’s a world-class leader that builds winning teams, executes with relentless rigor, and focuses on what’s right for customers. We’re also excited to partner with Chad Peets and the RPT team to build Cognition’s GTM team. Chad was Chris’ co-pilot in building Snowflake’s world-class sales team. Welcome to Cognition, Chris.

My conversation with @AlexTaubman, co-founder and CEO of Long Lake. Long Lake is 3 years old, has 30,000 employees, $4 billion in revenue, and just took Amex Travel private. Alex and his partners have spent the last three years building Long Lake with almost no public profile. They started in HOA management and expanded into five service lines. Their latest deal: $6.3 billion for American Express Global Business Travel. Long Lake buys great businesses and makes them better with AI. Their engineers sit alongside the people doing the work, understand what slows them down, and build tools that give them more time to serve customers. We talk about what he learned growing up in a family of entrepreneurs, why Long Lake built its own AI platform, what Henry Singleton and the Rales brothers taught him about compounding, and why the best partners make you more ambitious. Alex wants to spend the next 50 years on this. We talk about how far it could go. 0:00 The $6.3 billion Amex GBT deal 1:21 Bringing AI to the real economy 6:17 Why greater productivity can mean more jobs 11:29 A prepared mind and a tight acquisition filter 16:01 Nexus and the AI platform behind Long Lake 17:32 Put the engineers where the work happens 20:36 Why own the businesses instead of selling software? 22:28 Build tools people want to use 25:24 A high bar for talent, acquisitions and technology 28:03 What his grandfather taught him about removing friction 36:40 Learning capital allocation at Goldman Sachs and Oaktree 41:01 Buying founder-owned businesses with permanent capital 44:35 How the Long Lake team came together 47:26 The best partners make you more ambitious 49:28 More than $4 billion in projected revenue 53:32 Why going public could expand Long Lake’s ambition 54:23 Henry Singleton and staying flexible 55:57 John Malone and the businesses that will endure 57:57 Why Long Lake doesn’t plan to sell 1:00:13 Could Long Lake become a trillion-dollar company? Includes paid partnerships.

Today, Long Lake completed our $6.3B acquisition of Amex GBT. Long Lake acquires and transforms generational businesses with AI across the American services economy. Amex GBT is the travel partner for 17,500 businesses in 140 countries. Last year, Amex GBT booked 35 million trips for 10 million travelers. This marks Long Lake’s 40th acquisition, and our family of companies now employs nearly 30,000 people. We founded Long Lake three years ago with the thesis that AI is going to change every company, but there’s a large overhang between AI capabilities and how most businesses leverage AI tools. We partner with strong, profitable, and growing businesses to help them deploy AI and improve their customer service. Our first cohort of companies has doubled their EBITDA in less than two years through topline and productivity growth, all while increasing headcount. (We’re proud to say that we’ve never conducted a layoff.) We’re excited to share a bit more about what we’ve been up to.

Devin Mobile is now available in beta. Join the waitlist at the link below.

Cognition has crossed $1B in annualized revenue run rate. This milestone belongs to our customers. Here's how a few of them are building with Devin.

More Power.

More capable models will introduce increased biological risk. The magnitude is fiercely debated, the direction is not. We need more resilient biodefense.

UK finance teams have waited long enough. Ramp is now live in the UK. Sorry we’re late. ramp.com/uk

We started Sequence (@seqholdings) with a clear conviction: the holding company of the next century will be a technology company that owns and operates businesses. Today is an important step in that journey. We’re thrilled to announce that Sequence, along with the Dell Family Office and the Baldwin family and management team, have agreed to take The Baldwin Group private. I’m excited to partner with Trevor Baldwin and the broader team as we help extend Baldwin’s lead as the insurance firm of the future. Read more here: ir.baldwin.com/news-releases…

Introducing SWE-2, our closest model yet to the frontier. On leading evals, it scores on par with recent frontier models – at up to 70% lower cost. We scaled RL to multiple trillions of parameters, with a refined recipe that pushes the Pareto curve on both capabilities & cost.