AstraZeneca recently made a roughly $10 billion offer to buy Rhythm Pharmaceuticals, a deal that would expand its portfolio of rare disease treatments on.wsj.com/4A7zDfV

Dr. Annie Andrews, a pediatrician and gun-safety advocate, has defeated Republican Sen. Darline Graham for a South Carolina Senate seat, according to the Associated Press. She’s the first Democratic senator to be elected in the state since 1998. on.wsj.com/4AgLUPr

@MHackman is one of the coolest people I know, and in this amazing video she takes you to her Persian Jewish community to explore the complicated politics of the ongoing war in Iran. Definitely worth watching: wsj.com/video/series/rooted-…

NEW: "A 37-year-old Genentech scientist died in his San Francisco home last month of an overdose from a dangerous new opioid found in products sold openly in smoke shops and gas stations." By @abineely and @alyce_mcf sfchronicle.com/sf/article/k…

Exclusive: A new Labor Department regulation aims to pry open the business model of PBMs, powerful companies that oversee hundreds of billions of dollars’ worth of drug spending on.wsj.com/3W8xodS

To the scientific world, Moderna’s cancer vaccine’s results proved that a highly personalized, immune-targeting medication can work. To investors, it didn’t work well enough. W/ @xavierjohnm: wsj.com/health/pharma/modern…

EXCLUSIVE - Top RFK Jr. ally and adviser Calley Means has quit the Trump administration. Means was frustrated by White House delays of some of Kennedy’s popular food policies and blamed others in the administration for allowing food companies and special interests to have too much sway, people familiar with the matter said. One of them described him as “disillusioned.” wsj.com/politics/policy/call…

#ESMO26: The embargo on LBA1, “INTerpath-001: Phase 3 study of the mRNA-based individualised neoantigen therapy intismeran autogene plus pembrolizumab versus pembrolizumab alone for adjuvant treatment of resected stage IIB-IV melanoma”, has been breached. As the data are now publicly available, ESMO has released the information contained in the abstract and has lifted the embargo on the full dataset.

Medicaid data show some private-equity-backed chains billed far more hours than rivals. Companies say patient needs guide treatment. on.wsj.com/4z4imEu

New notice from FDA on a“Fit-for-Purpose Rare Disease Framework Initiative” under review at OMB. Expect an upcoming request for information and public meeting on this:

Drugmakers are targeting muscle preservation and fat loss as they build the next generation of weight-loss medications. on.wsj.com/3Vd54GL

NEW with @LizzyLaw_: The Trump administration is rolling out a program aimed at getting Medicare to match drug prices in other countries for certain high-cost drugs Pharma companies that cut deals with the admin expected to be exempt wsj.com/health/pharma/trump-…

NEW: A next-generation weight-loss drug from Eli Lilly, when combined with Zepbound, helped people lose substantially more weight than Zepbound alone, according to a new study wsj.com/health/pharma/lillys… via @WSJ

NEW: RFK Jr.'s efforts to revamp America’s food system have hit their biggest hurdle yet: The White House. Trump aides are concerned Kennedy's ideas aren't feasible and could fuel litigation against food companies. One of Kennedy’s top aides, Calley Means, accused White House officials of trying to block the definition to cater to special interests. Inside the clashes over the future of American food: With @jessenewman13 & @jdawsey1 🎁🔗wsj.com/politics/policy/rfk-…