Dr. Carlos Collet and Dr. C. Michael Gibson discuss the P4 Trial: Comprehensive CCTA-guided PCI strategy was associated with a lower rate of target vessel failure at 12 months compared to IVUS-guided PCI (4.1% vs. 4.8%) among patients with chronic coronary syndrome or stabilized acute coronary syndrome, supporting procedural safety and non-inferiority.
Watch video here: clinicaltrialresults.org/wp-…
Presented at #TCT2026:
In a randomized trial, CCTA-guided PCI with structured preprocedural planning and intraprocedural guidance was noninferior to intravascular ultrasound–guided PCI with respect to target-vessel failure at 12 months. Full P4 trial results: nej.md/48jfVly@crfheart
ALT A graph from the Original Article "Coronary CT Angiography versus Intravascular Ultrasound Guidance for PCI." The trial name, P4, is in parentheses after the title. The graph shows the cumulative incidence of target-vessel failure (primary end point), defined as a composite of death from cardiac causes, target-vessel myocardial infarction, or ischemia-driven target-vessel revascularization, at 12 months. The trial results are being presented at the Transcatheter Cardiovascular Therapeutics 2026 Conference. The logo of the New England Journal of Medicine is at the bottom.
P4 is out: CT-guided PCI was noninferior to IVUS-guided PCI for 12-mo TVF (4.1% vs 4.6%; n=1,105, 23 centers). Procedures were 17 min shorter with less contrast and radiation, and safety was similar. CT moves from gatekeeper to procedural tool. #TCT2026@ColletCarlos
Introducing the Sandoval Troponin Lab™.
Interactive. Visual. Open Access.
For years, clinicians and laboratory medicine specialists worldwide have worked to advance our understanding and use of cardiac troponin in the diagnosis of acute myocardial infarction. Yet, as assays, concepts, classifications, and diagnostic algorithms continue to evolve, the field has become increasingly complex.
The Sandoval Troponin Lab™ is a free, open-access educational resource designed to make cardiac troponin more intuitive, accessible, and engaging through interactive learning and visualization.
💻 systole.live/labs/troponin.h…
This is an early beta version, and feedback is welcome. Please reach out if you're interested in collaborating. Special thanks to my longtime partners and collaborators, Professors Allan Jaffe and Fred Apple, for their initial input.
@CianPMcCarthy@HighSTEACS@chapdoc1@richardbody@louiseacullen@loridanielsmd@OmlandRn@smithECGBlog@MahlerHEARTpath@richardbody
Today, we unveil the P4 randomized trial
The main question:
Can CT-guided PCI achieve similar outcomes compared to IVUS-guided PCI?
Join us in the Main Arena at #TCT2026@crfheart
How can CT complement angiography and intravascular imaging in PCI? Drs. Sandoval and Escaned discuss CT-guided PCI, from preprocedural planning to intraprocedural guidance.
Watch: hubs.ly/Q04Ctppw0#cardiotwitter#CCTA#TCT2026
Traveling to #TCT2026? 🎙️ Listen on your way to San Diego!
Coronary Corner Ep. 14: getting the image right for CT-guided PCI, from CCTA acquisition to photon-counting CT, with Drs. @JoaoLCavalcante & Victor Cheng.
“It’s not stopping at an arbitrary number.”
▶️ piped.video/watch?v=0dPr-XvO…
🩺 The countdown is on! In less than three weeks, leading physicians will gather at the Minneapolis Heart Institute Foundation for the 4th Annual CT-guided PCI Summit on November 12–13! 🗓️