Group leader at Freie Universität Berlin

We usually think of mRNAs carrying the information needed to make a protein (the central dogma...). But how can the encoded protein control the fate of its encoding mRNA? 🤔 Check out our review on the topic 👇 cell.com/molecular-cell/full…
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Eva Absmeier retweeted
If you agree that ERC should remove their academic age limits on ERC grants - please Sign this Petition! Please also RT: #EDI #science #EuropeanScience #ERCgrant chng.it/zvm4fDmFdj via @UKChange
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Very fun collaboration and I am very happy to have worked with @MarkusHopfler on tubulin auto-regulation!
🚨preprint alert🚨 What do cells do if there's too much tubulin around? They get rid of the encoding mRNAs! Check out the mechanism for ribosome-associated tubulin mRNA decay 👇 Excellent collaboration with @AbsmeierEva @lapassmore @Ivana_Gasic! biorxiv.org/content/10.1101/…
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come to Wonderful Copenhagen - 5th year in a row of this great symposium rotating in the CryoNET network (Copenhagen, Aarhus, Umeå, Stockholm)
Looking forward welcoming you for the 2022 cryoNET symposium in CPH!!! The deadline for abstract submission is extended to 15 Sept @cryoEM_Papers #CryoEM please retweet
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Eva Absmeier retweeted
Thus, Pol II dimerisation may provide a mechanistic explanation of the allosteric model of termination!
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Eva Absmeier retweeted
New work from @_M_Carminati shows that dephosphorylation of RNA polymerase II by CPF (the 3' end processing machinery) promotes Pol II dimerisation. @mcemremnv @MRC_LMB @ERC_Research
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Eva Absmeier retweeted
New work led by @AbsmeierEva and @vishy_chandra shows how human CCR4-NOT recognises slow-moving ribosomes in codon-optimality decay. @FJ_OReilly @RappsilberLab @ERC_Research @MRC_LMB
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Eva Absmeier retweeted
PolyA tails on eukaryotic mRNAs are added after co-transcriptional endonucleolytic cleavage of the pre-mRNA. @VBoreikaite has now reconstituted specific and efficient 3ʹ-endonuclease activity by human CPSF with purified proteins. @ERC_Research @MRC_LMB biorxiv.org/content/10.1101/…
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We solved a long-standing question about the precise role of the NSUN4 RNA methyltransferase in mitochondria. A fantastic collaboration between @BurtonNick @ericmiskalab from the @GurdonInstitute and the Venki Ramakrishnan group @MRC_LMB @_nirupa_desai @Hanting_Yang
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👇I can look at this forever!
Replying to @lapassmore
We show that the Mpe1 subunit of CPF (in orange) 'senses' RNA (grey) recognition by Yth1 (magenta).
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Eva Absmeier retweeted
I am very happy to share our work with @torbenheick and @AndrzejDziembo1 labs on how the length of poly(A) tails is determined. @MRC_LMB @ERC_Research
In @GenesDev, researchers from @torbenheick's lab @MolBiolAU, @lapassmore's lab @MRC_LMB & @AndrzejDziembo1's lab @IIMCB_Poland revealed the surprising finding that more than one pathway serves to control poly(A) tail lengths in S. cerevisiae tinyurl.com/eckuamw5
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In a new Science study, researchers present #RoseTTAFold—an #AI network that produces structure predictions with accuracies approaching those of DeepMind’s AlphaFold2. The tool’s code is freely available. Read more: fcld.ly/xgy73r8
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Eva Absmeier retweeted
Yesterday, the German Society for Crystallography (DGK) awarded Manfred Weiss @ManfredSWeiss with the Will-Kleber Medal 2021 for his methododological developments in crystallogrpahy. Congratulations. @HZB @HZB_BESSY
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Excited to have contributed, together with Markus C. Wahl, to the second edition of "RNA Remodeling Proteins". Our work on the spliceosomal RNA helicase Brr2 can be found here: link.springer.com/protocol/1…
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Check out the new paper on the ASCC3 NTR bound to ASCC2.
New paper from Markus Wahl’s group @FUBiochemistry : The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations go.nature.com/36oVy63
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Eva Absmeier retweeted
Structural basis of ribosomal frameshifting in SARS-CoV-2. Stimulatory viral RNA pseudoknot lodges at mRNA entrance channel, priming the ribosome to change the reading frame. Collaboration with @bode_lab, @ProfVolkerThiel, and Atkins labs.disq.us/t/3si8nus
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Eva Absmeier retweeted
Excited to announce that I am establishing my group at @WEHI_research early next year! I am so grateful to my mentors @lapassmore and Sarah Butcher for shaping my scientific career. Please contact me if you are interested in joining us to study multi-protein complexes by #CryoEM.
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