Nechemia-Arbely Lab@ArbelyYael

Human centromeres lab at University of Pittsburgh Hillman Cancer Center. We study how centromeres are epigenetically maintained throughout the cell cycle.

 UPMC Hillman Cancer Center
nechemia-arbelylab.org/
Joined April 2019
3 Photos and videos
Thrilled to have contributed to this beautiful work from the O'Sullivan lab, now out @Nature! nature.com/articles/s41586-0…🧬 @ginibh31 @MahlkeMegan @KarlsederLab @UPMCHillmanCC

Centromeric footprints preserve telomere integrity in ALT cancers

Nature - Centromeric DNA repeat insertions and CENP-A chromatin assembly are identified as genomic signatures that preserve telomere integrity in ALT cancer cells.

nature.com
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Our new paper is out in @CellReports 🎉 Congrats to @MahlkeMegan, and the whole team and collaborators! Check it out here: cell.com/cell-reports/fullte…

Neocentromeres fail to maintain DNA methylation boundaries, driving CENP-A drift, instability, and...

Mahlke et al. find centromeres and neocentromeres display heterogeneous, plastic CENP-A and DNA methylation patterns within populations. Unlike centromeres, neocentromeres lose DNA methylation...

cell.com
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We show that while native centromeres maintain a stable DNA methylation boundary through extended proliferation, neocentromeres don't, driving CENP-A drift, domain expansion and chromosome missegregation.
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Thrilled to have contributed to this beautiful work from the O'Sullivan lab, now out @Nature! nature.com/articles/s41586-0…🧬 @ginibh31 @MahlkeMegan @KarlsederLab @UPMCHillmanCC

Centromeric footprints preserve telomere integrity in ALT cancers

Nature - Centromeric DNA repeat insertions and CENP-A chromatin assembly are identified as genomic signatures that preserve telomere integrity in ALT cancer cells.

nature.com
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We show that centromeric α-satellite repeats and CENP-A footprints assemble at telomeres in ALT cancers, a striking new link between two chromosomal landmarks.
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Very excited to share our work @MahlkeMegan in great collaboration with @NAltemose @khmiga Peter Campbell and Rachel O'Neill revealing that human centromeres are heterogenous and naturally evolve over prolonged proliferation. Check it out here biorxiv.org/content/10.1101/…
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Nechemia-Arbely Lab retweeted
Megan Mahlke@MahlkeMegan
12 Feb 2025
How is epigenetic centromere identity maintained at such rapidly evolving genomic loci? We reveal the evolving epigenetic plasticity of human centromeres/neocentromeres across proliferation that is key for flexible centromere maintenance. @ArbelyYael biorxiv.org/content/10.1101/…
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Nechemia-Arbely Lab retweeted
LifeScienceAlliance@LSAjournal
11 Jan 2023
Plasticity in the position of CENP-A enrichment and location of kinetochore recruitment is accompanied by precise CENP-A maintenance across the cell cycle to preserve unique epigenetic centromere identities @MeganMahlke @ArbelyYael @PittTweet life-science-alliance.org/co…
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Nechemia-Arbely Lab retweeted
Zha Lab@zha_lab
13 Feb 2022
Thank Drs. Reid, Nechemia-Arbely (@ArbelyYael), and Deegan (@TDDeego ) for another exciting rising star section. In the coming week, Nima @NimaMLab will visit Social DNAing with a friend of DNA...RNA. Signup at cancer.columbia.edu/research…
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Nechemia-Arbely Lab retweeted
Dwi U. Kemaladewi@DKemaladewi
2 Apr 2022
Thank you @PittTweet for the fun faculty honors convocation 😍🥳 So nice to celebrate in person & congratulate my amazing School of Medicine junior faculty @ArbelyYael @carvunis @YinanGong @jishnu1729 🥂 👏 The last standing #newPI group got to hang out with @ProvostCudd 😉😂😍🌺
University of Pittsburgh@PittTweet
1 Apr 2022
LIVE | Faculty Honors Convocation 2022 🎉 Congratulations to our faculty members who have distinguished themselves through teaching, research, and public service. piped.video/sDYE_l7A-P4
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Excited to share our first pre-print from our lab @UPMCHillmanCC and @PittTweet ! If you are interested in how human centromeres are epigenetically defined and maintained in different cell types and across the cell cycle, please check it out! biorxiv.org/content/10.1101/…

Epigenetic centromere identity is precisely maintained through DNA replication but is uniquely...

Centromere identity is defined and maintained epigenetically by the presence of the histone variant CENP-A. How centromeric CENP-A position is specified and precisely maintained through DNA replica...

biorxiv.org
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We show that centromeric CENP-A position varies significantly between human cell lines of different origins, indicating the presence of undocumented CENP-A epialleles
Our findings reveal that CENP-A is precisely re-loaded onto the exact same centromeric sequence and position during DNA replication
We demonstrate that CENP-A is retained at the same centromeric sequences during DNA replication as in its initial loading at early G1 using the T2T genome assembly
We show that centromeric CENP-A position is highly similar in a single cell line and its derived clones over multiple cell divisions
Congratulations to the @UPMCHillmanCC Scientific Retreat Junior Scholar Award Winners! @RPatelMDPHD @TLHagan @ArbelyYael @hwbulls @KMBaileylab @nicole_scheff @PittHealthSci
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We are hiring! Please share... jobrxiv.org/job/university-o…

Postdoctoral Fellow -Epigenetics of human centromeres

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

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jobrxiv.org/job/university-o…

Postdoctoral Fellow -Epigenetics of human centromeres

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org
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Congrats Andy!!
Andrew Holland@AHollandLab
3 Dec 2019
Our new paper is out today in @NCB. This work was a wonderful collaboration with the lab of Alice Meunier. Congrats to Olivier Mercey and Michelle Levine who performed most of the experiments. nature.com/articles/s41556-0…
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