Dear All, Please find us at Bluesky. @becklab.bsky.social Martin
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Difference between diffusion and flow? If you drip paint into a river it locally dissolves by diffusion. It goes downstream driven by flow. We quantify flow through #nuclearpores in response to rapid nuclear size changes. @MPIbp #TEAMTOMO @MolecularCell cell.com/molecular-cell/full…
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We propose that the dilation state of #nuclearpores modulates its permeability and consequently fluid flow, which is important in response to osmotic stress or when cells squeeze through constrictions. Great collaborative effort by @pc_hoffmann @aobarska Henry Kim and @HummerLab
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Beck Laboratory retweeted
Nature research paper: In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor go.nature.com/3BB0KHA
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Congrats to @HuaipengXing for defending his PhD. First PhD hat @goetheuni 😎
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… and perfect timing. Work by @HuaipengXing with @FrydmanLab out @Nature. PDCD5 binds virtually all open #TRiC, while closed TRiC forms clusters inside of cells. Congrats to all authors. rdcu.be/d3dmN
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Emotional leaving event for @Reiya_Tan1guch1 who is departing @MPIbp towards @riken_en. Best of Luck Reiya!
Many congratulations to Reiya Taniguchi @018_xviii , for securing the @EMBO long-term fellowship.
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We modified our STED🔬to make it more efficient ('smart') to acquire high-resolution data of small and rare objects in a 3D cell volume. This enabled collecting a large amount of data in a fully automated fashion. With that, we visualized the ultra-structure a nuclear body👇🏻(1/3)
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Did you know that nuclear pore complexes can turn up outside the nuclear envelope? Studying these, @JennySachweh, Bernhard Hampoelz and others uncover that the surrounding cellular milieu determines NPC composition via the nuclear transport system itself. #teamtomo #NPC A 🧵
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Compartment-specific chaperoning and transport of peripheral Nups through the nuclear transport system control both the (a)symmtery of NPCs and explains how the cell can convert NPC precursors into functional NPCs upon relocation into the NE.
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Beck Laboratory retweeted
🙋🏻🔬 #EMBOinsitu is open for registrations! From cryo-EM to multi-scale modelling - what types of biological questions can be addressed using in situ structural biology? 📜 Submit abstract by 12 Nov 📅 4 – 7 Feb 2025 📍 EMBL Heidelberg and Virtual ➡️ s.embl.org/iss25-01
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Ready to lead your own research team-?😎The Max Planck Society offers you the chance to head an independent Research Group at a participating Max Planck Institute of your choice - the next open topic call starts on Sep 9, 2024. Stay tuned for updates!🌟 mprg.mpg.de
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#PhD, #DnD(?) & #postdoc positions in “theory and methods for non-equilibrium atomistic simulations of complex #biomolecules” – Interested in theoretical and computational #biophysics? Check out the #JobAlert & apply here ⬇️: Shares welcome! #hiring #job mpinat.mpg.de/4588467/60-23?…
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Beck Laboratory retweeted
We recently discovered a priority code in presequences of mitochondrial precursors. Some are much ‚stronger‘ than others because they specifically recruit Hsp90 cochaperones and make use of Tom70. Very unexpected, at least for us. You can read the preprint biorxiv.org/content/10.1101/…
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Beck Laboratory retweeted
Incredibly proud of Matthias Mann for winning this year's Dr. H.P. Heineken Prize for Biochemistry and Biophysics together with Ruedi Aebersold! Their pioneering work has transformed protein research and is reshaping the future of biomedicine! #proteomics heinekenprizes.org/2024/06/1…
Congratulations to Matthias Mann who receives the prestigious #HeinekenPrize for Biochemistry and Biophysics with Ruedi Aebersold for ‘revolutionizing the way proteins are studied’. ❕heinekenprizes.org/2024/06/1… ❕biochem.mpg.de/mann @labs_mann #proteomics
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