Is autoimmune sclerosing cholangitis the same as PSC? Does overlap even exist? Thank you @JHepatology for accepting, and to @amandaricciuto for writing a stellar piece! @BinitaKamath @AutoImmuneLiver sciencedirect.com/science/ar… @jfergus75 @TheBileDoc @PSCSupportUK @PSCPartnersCa

1/7 In a randomised phase 1b trial in allo-HCT, 4 days of oral vancomycin then 10 days of a 16-strain bacterial consortium (SER-155) went with bloodstream infection in 10.0% of patients vs 42.9% on placebo. The CI crosses 1. Nature Medicine, 2026. nature.com/articles/s41591-0…

🔈 🗣️ Have a read of this excellent new review by @dr_aditi_kumar and team on bile acid diarrhoea 👏 This article covers pathophysiology, diagnosis and treatment, with novel tests and therapeutics emerging 🦠 💊. A must-read for all gastroenterologists, with helpful tips for clinic 👀! fg.bmj.com/content/early/202… @PhilSmithIsBack @OTavabie @TrevorTabone @eathar_s @IrenePerezMD @KGananandan @zare_benjamin @medicalreg @dtleiberman @BSGtrainees @WorldGastroOrg @ulstergastro @AmCollegeGastro @Aegastro @SAGES_updates @WAGE_media #GITwitter #gastroenterology #diarrhoea #MedEd

When transplantation is not an option, every conversation and every choice matters. Hear from Tess from PSC Support Australia, who raises important questions about access to clinical trials, the need for effective medical treatments, and the importance of honest, transparent conversations about all aspects of care, including palliative care. 💬 Her message reminds us that patients deserve to be informed, heard and actively involved in decisions about their health and future — even when the conversations are difficult. 🌍 Different countries, shared experiences, one global voice for PSC awareness. #PSCGlobalDay2026 #PSCawareness #PatientVoices #SharedDecisionMaking #PatientCentredCare #ELPA

Research brings hope, but access to research opportunities remains a challenge for people living with PSC. Hear from Kerrie, President of PSC Support Australia, who highlights the challenges of securing research funding in an extremely competitive environment and the lack of clinical trial opportunities currently available to PSC patients in Australia. 💬 Her message reminds us that advancing PSC research requires sustained investment, international collaboration and equitable access to clinical trials. Every patient, regardless of where they live, deserves the opportunity to benefit from scientific progress. 🌍 Different countries, shared challenges, one global voice calling for more research and better treatment options for PSC. #PSCGlobalDay2026 #PSCawareness #PSCResearch #ClinicalTrials #PatientAdvocacy #ELPA

🫀 Can coronary atherosclerosis actually regress? Our new randomized FLOWPROMOTE trial analysis, published TODAY in JAMA Cardiology, shows remarkable coronary plaque regression with intensive LDL-C lowering! Atherosclerosis is not necessarily a one-way process. 📄 JAMA Cardiology: doi.org/10.1001/jamacardio.2… #Atherosclerosis #LDL #Cardiology #CCTA

View point 1: we new this already, BUT View point 2: validation across large sample sizes like this are critically important! How can (should) we incorporate this into ALF listing criteria?? Important study - well done to those involved!

🧬 #GUTRecentAdvancesInClinicalPractice Could genetic testing help explain adult cholestatic liver disease when standard investigations leave questions unanswered? In this #GUTRecentAdvancesInClinicalPractice paper, Liebe et al discuss the use of genetic analysis in adult cholestatic liver disease, drawing lessons from progressive paediatric syndromes and cohort studies. The article considers how genetic insights can improve understanding of disease and support clinical assessment. 📄 “Use of genetic analysis in adult cholestatic liver disease: lessons from progressive paediatric syndromes and cohort studies” Read the paper here: bit.ly/4BsvCo0 DOI: 10.1136/gutjnl-2025-337027 📖 Gut, November 2026 | #GUTRecentAdvancesInClinicalPractice — Hepatology 🔗 Read the full November issue here: bit.ly/4yyX00Z

A significant milestone in global hepatology: five international liver societies establish a unified definition of acute-on-chronic liver failure (ACLF). Published in the Journal of Hepatology, this landmark consensus brings together EASL, AASLD, APASL, ALEH and SOLDA to establish a common framework for ACLF diagnosis, staging and clinical trial design. The consensus addresses longstanding regional differences in definitions and aims to support more consistent clinical practice, international research collaboration and the development of effective therapies. “The publication of this landmark global consensus represents a historic moment in hepatology, bringing together five major international liver societies for the first time to speak with one unified voice on acute-on-chronic liver failure,” said Professor Debbie Shawcross, Professor of Hepatology & Chronic Liver Failure at the Roger Williams Institute of Liver Studies, Kings College London, and EASL Secretary General. By establishing a shared, evidence-based framework, this collaboration represents an important step towards more equitable patient care and improved outcomes for patients with ACLF worldwide. Read the full consensus: journal-of-hepatology.eu/art… Read the press release: easl.eu/easl-and-global-live… #EASL #Hepatology #ACLF #LiverDisease #LiverResearch @JHepatology @AASLDtweets @APASLnews @alehlatam @Solda_Society @DebbieShawcros1

Different countries. Different journeys. One global voice for PSC.🌍 What does it really mean to live with Primary Sclerosing Cholangitis (PSC)? Behind every diagnosis is a person navigating uncertainty, making difficult decisions, adapting to everyday challenges and hoping for a better future. 🌍 This #PSCGlobalDay2026, we are putting patients and their lived experiences at the heart of the conversation. 🎥 Over the coming days, hear directly from patients, families and caregivers around the world as they share their personal journeys — from diagnosis and daily life to transplantation, emotional wellbeing, treatment challenges and hopes for the future. 💬 Because patients are more than their diagnosis. Their experiences matter, their needs deserve to be understood, and their voices must be heard. Join us as we bring these voices together, raise awareness and remind the world that no one should face PSC alone. #PSCGlobalDay2026 #PSCawareness #PatientVoices #LivingWithPSC #PatientCentredCare #GlobalPSCCommunity #ELPA #PSCaware

Geordi La Forge actor LeVar Burton pays tribute to his “Star Trek” co-star Patrick Stewart: “He was family. There is no other context in which to hold him that makes sense. I am lucky to have known and loved so many of the facets of a soul so rich in talent and generous of heart. Of all the Dames and Knights I’ve known he was deep down-the silliest.” variety.com/2026/tv/news/wil…

Sir Patrick Stewart was knighted in 2010 for his services to drama, capping a career that began on the British stage. ⁠ He made his television debut in Coronation Street before later appearing in the Star Trek and X-Men franchises. 🔗 trib.al/AwuaRXn

They don’t make them like him anymore. Rest in peace our Captain, our Professor…

“Avengers: Doomsday” directors Anthony and Joe Russo pay tribute to Patrick Stewart, calling him a “childhood hero": “A legendary actor with an unmistakable presence, and an unmatched integrity. Thank you for entertaining all of us, sir. And for teaching us humanity, both on and off the screen. Sending our love to your family, friends, and fans around the world.” variety.com/2026/film/news/p…

Patrick Stewart's final movie role will be in "Avengers: Doomsday," in which he reprises the iconic "X-Men" character Charles Xavier. In one of Stewart’s now-final interviews published by TV Insider in July, the actor spoke about his decision to star in “Avengers: Doomsday” and told fans that he would never “retire” from acting. “As any actor my age will tell you, there are fewer and fewer available roles as we get older. That being said, I still continue to receive interesting offers and I love being challenged by new work,” Stewart said at the time. “I can’t imagine ever officially retiring. I’ll always and forever be an actor.” variety.com/2026/film/news/p…

Ian McKellen pays tribute to Patrick Stewart, his close friend of many years: “Before everything else, Patrick was defined by being born and bred in Yorkshire, the proud county in the north of England which he loved to the end. You could hear it in his accented voice and in the stern honesty with which he told you what he thought and felt. Yorkshiremen have no truck with half-truths or avoidance of big issues. He wore his heart on his sleeve, which made him a man to rely on, to admire and in my case, love,” McKellen wrote on Instagram. “America was his adopted home, where he met his adored Sunny who has cared for him through sickness and health, through thick and thin. But he never forsook his origins: and the proudest achievement of the most respected and beloved actor of his generation on either side of the Atlantic, was his appointment as Chancellor of Huddersfield University in Yorkshire.” “His farewell performance in ‘Avengers: Doomsday’ is yet to be seen,” McKellen concluded. variety.com/2026/film/news/i…

Understanding PSC: why, how and what comes next. Jean-Philippe highlights the importance of helping people understand their diagnosis, what is known about the disease, how to manage it in the long term and how to navigate the challenges ahead #PSCGlobalDay2026 #LetsBeatPSC #ELPA

Good data - be keen to see a head to head with IV vedo, not SC (will be real world data rather than trial for obvious reasons)

The power of community: no one should face PSC alone. Hear from Sarah from PSC Partners Seeking a Cure Canada, who highlights the importance of finding connection, understanding and support within the PSC community — especially for younger patients navigating life with a rare chronic disease. 💬 Her message reminds us that connecting with others who share similar experiences can make a real difference. A strong community provides not only information and support, but also a sense of belonging, encouragement and hope for the future. 🌍 Different countries, shared experiences, one global voice for PSC awareness. #PSCGlobalDay2026 #PSCawareness #PowerOfCommunity #YoungPatients #PatientVoices #ELPA European Liver Patients' Association

Living with PSC is more than a diagnosis - it's about being seen, heard & understood as a whole person. Mark from PSC Support UK highlights the importance of recognising symptom burden of PSC and understanding how the disease affects daily life. #PSCGlobalDay2026 #LetsBeatPSC

Looking forward to speaking at @AASLDtweets #TLM2026 on Sun, Nov 8! We will be discussing emerging therapeutics to prevent steatotic liver disease–related HCC at the AASLD/JSH Session on liver cancer prevention. @HoshidaYujin @nicole_rich8 @JosephCAhnMD