PI of the #keedylab at the @cuny @asrc_gc. Interests: protein structural biophysics & puns. Migrated to @dkeedy.bsky.social
NY, NY
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I'm X-iting this site... You can find me under bluer skies elsewhere: @dkeedy.bsky.social
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The Keedy Lab at the CUNY ASRC in NYC is looking for a postdoc! Our lab uses avant-garde structural biology experiments and computational analyses to reveal conformational ensembles that underlie biological function. See attached flyer and keedylab.org. Please share!
ALT Keedy lab postdoc ad flyer with position details
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Daniel Keedy retweeted
"I wish it need not have happened in my time," said Frodo.
"So do I," said Gandalf, "and so do all who live to see such times. But that is not for them to decide. All we have to decide is what to do with the time that is given us.”
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Daniel Keedy retweeted
I'd start with the pioneers of protein sequence and structural bioinformatics -- the foundation of protein structure prediction & computational design. Margaret Dayhoff, Dame Janet Thornton, Jane Richardson, Helen Berman, Ruth Nussinov, Anna Tramontano, Christine Orengo & more.
Can someone please start a thread of women in protein design? It's not my field so I can't immediately tag accounts but it would be a nice way to bring attention, especially in light of the currently all-male Nobel run this year. Happy to amplify for reach. TYIA!
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Research at @CUNY continues to trend upwards: cuny.edu/news/cuny-reports-r… Glad to play a part in that here at the @asrc_gc @GC_CUNY @CityCollegeNY !
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Another cool quote: "CUNY’s mix of quality and affordability propels almost six times as many low-income students into the middle class and beyond as all the Ivy League colleges combined." #beerANDtacos
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Daniel Keedy retweeted
Dear Colleagues,
We are recruiting an endowed assistant professor at the Laufer Center for Physical and Quantitative Biology laufercenter.org/ The job description is posted in
apply.interfolio.com/150310
May I suggest you share this opportunity with colleagues?
Kind regards,
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Welcome to the SBI crew, @Frances84469032 !!!
Proud to announce Francesca Vallese @Frances84469032 joining @asrc_gc Structural Biology Initiative and @CCNYChem as a new Assistant Professor, bringing expertise in cryo-EM and biochemical studies of cytoskeletal complexes! Deets at valleselab.com. Welcome, Francesca!
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Daniel Keedy retweeted
Really enjoyed working on this one - give our latest preprint on the relationship between #phosphatases and #obesity a read!
biorxiv.org/content/10.1101/…
I'm excited to share our lab's latest @biorxivpreprint: biorxiv.org/content/10.1101/… This was a really rewarding collaboration between Virgil, @DrAliEbrahim, @blake_riley (& others not on Twitter/X) from @asrc_gc with the @Farooqi_Lab. (1/6)
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Daniel Keedy retweeted
A Cottrell Scholars Collaborative project to help integrate #Python coding into #STEM courses has helped coalesce a robust, interdisciplinary network extending beyond the #CottrellScholar community. bit.ly/4deNrKz
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Together with @Farooqi_Lab we showed that these mutations indeed diminish PTP1B activity both in cells and in vitro with recombinant protein -- despite being distributed throughout the 3D structure, far from the active site. (3/6)
ALT Left: Human variant locations plotted on 3D structure of PTP1B. Right: Michaelis-Menten plot for mutations showing significant reduction of enzyme activity.
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Finally, the most impactful mutations cluster near ligand binding hotspots, including some that allosterically affect the active site. Interestingly, this region is an allosteric inhibitor site for PTP1B's cousin SHP2, but has not been previously pursued for PTP1B... (5/6)
ALT The top human variant mutations in the PTP1B catalytic domain are shown next to small-molecule fragment binding sites, showing the allosteric mutation sites are ligandable.
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Overall, we think this study shows the value of coupling human genetics and structural biophysics to illuminate new paths for drug discovery! Of course, we have deposited our crystal structures in the @buildmodels PDB and will publicly release them ASAP per @ASAPbio_! (6/6)
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I'm excited to share our lab's latest @biorxivpreprint: biorxiv.org/content/10.1101/… This was a really rewarding collaboration between Virgil, @DrAliEbrahim, @blake_riley (& others not on Twitter/X) from @asrc_gc with the @Farooqi_Lab. (1/6)
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To explore the molecular basis of obesity and new ways to guide anti-obesity drug development, the @Farooqi_Lab found rare genetic variants in ~1k thin healthy people. Several were in one of my lab's favorite proteins, PTP1B -- a known drug target for obesity and diabetes. (2/6)
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Daniel Keedy retweeted
“I’m tremendously proud of how we’ve collectively taken an empty building in 2014 — & rebounded from 2020’s COVID challenges — to build dynamic & diverse teams of scientists.” —@nmrkaygee, director of the CUNY ASRC Structural Biology Initiative. #ASRC10 bit.ly/ASRC10
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