Presenting a novel axis that can fine-tune the immune response to glomerular and tubule cell damage:
Jamie R. Privratsky
@JamiePrivratsky & team
@DukeKidney @Duke_Anesthesia identify a novel myeloid cell-endothelial cell immunoregulatory axis, supporting a model whereby myeloid IL-1R1 activity constrains ER stress–mediated EBI3/IL27 secretion, thereby attenuating type I IFN expression in kidney endothelial cells and ameliorating
autoimmune nephritis.
The figure shows anti-IFNAR1 therapy abrogates kidney injury after NTS nephritis in mice lacking IL-1R1 specifically in myeloid cells (bottom); littermate controls (top).
#AKI #Nephrology #kidney #macrophage