Patrick was one of those icons who we somehow all took for granted would always be with us. I grew up as a fan, and was later gifted the privilege of becoming a colleague and friend, working with him for many years on “American Dad!”, “Family Guy”, and “Ted”. He was that rare actor who could take any bit of dialogue and elevate it, making a good writer sound great, and a great writer sound masterful. He was also as humble as they come. I remember exchanging emails with him a number of years ago when he was beginning day 1 of a new film. He commented to me that he always walked onto a new set feeling like the biggest novice there. My stunned reaction was the same as anyone’s would be. I said, “Patrick, if you feel that way, the rest of us are screwed.” We have lost a legendary actor today, and for many of us, a good friend. He will be deeply missed by the entire planet.

@DavidSinclair — @lifebiosciences’ first-in-human ER-100 data is back in the feed. Same optic-neuropathy / glaucoma Phase 1 we covered Saturday. Single intravitreal dose + oral doxy to turn on OSK. Well-tolerated through Day 56. Early visual-field improvements in 2 of 3. Dose escalation moving forward.

this is the easiest money on youtube right now and it's a lifechanging opportunity... faceless 3D shorts. clay planets, tiny rome, domino spirals, "you vs a blue whale" you've seen them. they're everywhere. and almost none of them have an animator it's one person, Opus 5.5 and 12 free repos 4 channels. 48 shorts a day. one prompt each. here's the full stack from idea to upload ↓ /faceless-studio ┃ ┣ FIND ┃ ┣ Exa MCP: what's blowing up in your niche this week ┃ ┃ github.com/exa-labs/exa-mcp-… ┃ ┗ yt-dlp: pulls the top shorts + transcripts so Opus copies what works ┃ github.com/yt-dlp/yt-dlp ┃ ┣ WRITE ┃ ┗ Claude Skills: hooks, 40s scripts and titles built for retention ┃ github.com/anthropics/skills ┃ ┣ BUILD ┃ ┣ Blender MCP: Opus builds and animates every 3D scene from code ┃ ┃ github.com/ahujasid/blender-… ┃ ┣ Hunyuan3D-2: one image in, a ready 3D prop out ┃ ┃ github.com/Tencent-Hunyuan/H… ┃ ┗ Blender: renders a short in about a minute, even on an old GPU ┃ github.com/blender/blender ┃ ┣ VOICE ┃ ┣ Kokoro: human-sounding voiceover that runs on your own PC ┃ ┃ github.com/hexgrad/kokoro ┃ ┗ WhisperX: captions timed to every single word ┃ github.com/m-bain/whisperX ┃ ┣ SCORE ┃ ┗ MusicGen: a fresh track for every short, nothing to license ┃ github.com/facebookresearch/… ┃ ┣ EDIT ┃ ┣ HyperFrames: titles, captions and the cut, written as HTML ┃ ┃ github.com/heygen-com/hyperf… ┃ ┗ ComfyUI: thumbnails that actually get the click ┃ github.com/Comfy-Org/ComfyUI ┃ ┗ POST ┗ n8n: uploads to every channel on a schedule while you sleep github.com/n8n-io/n8n one prompt in. one short out. four channels running. every week there are more of these channels. the good niches won't stay open follow me, my new article releases tomorrow you have to be there.

Dreams of AI ending aging and of AI killing everyone through a purely in-silico-designed pandemic both rely on this fallacy. It's understated here how much we lack ground truth data about what's happening inside of cells, or sensors to get that data. A single cell contains billions of protein molecules, across at least thousands of types, and at least trillions of interactions per second. Think we solved protein folding? We've made enormous progress predicting static protein structures. But these proteins constantly change their conformation and interact with one another, often in ways we can't observe or model accurately. Our best sensors capture a miniscule fraction of the activity in a living cell, orders of magnitude short of what's happening. We actually lack the ability to perceive what's going on that would be required to build such a bottoms up simulation. Let alone to scale this up to an organism or a global population. We know we have an expanding universe not because of breakthroughs in theory or computation - but because Edwin Hubble got new data by looking through the Hooker telescope. Possibly the greatest mind, Einstein, was wrong in his model of the universe because he lacked the right instrument to bring him the right data. That's where we are in biology. Our sensors are still so crude. No amount of pure computation or AI can build a perfect model. We need an instrument revolution in biology, not just a computational or intelligence revolution. AI can generate hypotheses, but without sufficient ground truth data, we can't know whether our simulations are modeling reality.

i just re created kurzgesagt's entire channel in 10 minutes with claude opus they have 0 competition because every video takes a full team of animators and 1200+ hours to make i turned it into a claude prompt that im giving out for free open claude code, paste the prompt, pick an idea, and your video is fully automated thank me later ↓ <inputs> Ask me for: one topic as a "what if" question (default: "What if the Sun vanished?"), the length (default 30 seconds), and whether I have an ElevenLabs key (if not, use a free local voice). </inputs> <direction> A Kurzgesagt-style animated explainer at 1920x1080, 30fps, drawn entirely in code: one 2D canvas plus one WebGL canvas for planets. Space: a vertical gradient #081d2c to #102348, five huge parallax nebula blobs (teal rgb 24,150,160 at 20%, blue 40,95,195 at 16%, coral 220,95,110 at 10%, indigo 60,70,175 at 15%), three star layers at parallax depths .12/.35/.6 that twinkle, 40% of the near stars drawn as 4-point sparkles. The Sun: radius 300px, half off the left edge. A radial gradient #fff7dc to #ffc857 to #ff8f4a with an offset highlight, additive halo rings at 1.23/1.48/1.76/2.1x the radius, 18 faint rotating ray wedges, 28 drifting glowing granules on its surface. Earth: an orthographic sphere in a fragment shader, 4x supersampled, from a 2048x1024 map painted from longitude/latitude polygons: land #5fc47a, forest #48ad6b, desert #f5c75f, rainforest #3a9d62, ice #f1f8ff, ocean gradient #4dc7eb to #1a66b8, white capsule clouds. Tilt .26 rad, spin .55 degrees per second. Day/night uses smoothstep(-.12, .24, N·L) with the light direction recomputed from Sun to Earth every frame. Navy night side with ~380 warm city lights, a coral band on the terminator, a cyan rim, ocean specular, an atmosphere halo that is stronger on the lit side. A small astronaut mascot (~180px) built from rounded rectangles: suit #f3f7fb, orange #ff8f4a boots, a visor gradient #1f5a73 to #0a1c2c with glowing cyan eyes that look at whatever matters, a blinking antenna light, an idle bob, squash and stretch on every pose. Type: Fredoka 600/700 only. Captions in caps with 3-6px letter spacing in teal #8fd8e6, gold #ffd98a or white, sitting in rounded pills of rgb(6,20,40) at 62%. Every line of text rises 1.3x its own height through a clip on an ease-out-quint. Finish: a vignette to rgba(4,4,20,.45) and a 6% film grain re-randomized 24 times per second. Banned: outlines, flares or loops on the Sun's edge, static infographic strips, full stops in on-screen text, text that fades in whole, AI images or AI video, Kurzgesagt's own characters, bird or music. </direction> <structure> 30 seconds, every line of narration gets a camera move or a transformation, nothing ever holds still. Tight on the Sun at 2.25x (0s) → on the word "vanished" it swells 6% for 0.22s, collapses in 0.33s, then a white flash and a shockwave ring (1s) → pull back to 1x revealing Earth still lit and the astronaut staring at the empty spot (1.6-3s) → on "eight" an 8:20 countdown slams in from 1.7x to 1x and starts ticking, a "LAST LIGHT" label rides the edge of the growing dark disc (3.2s) → dive to 2.3x on Earth with light streaks flowing in (5.6s) → on "you" a YOU pin drops (7s) → on "left" a photon lands on the pin with "THIS LIGHT LEFT THE SUN / 8 MIN 20 SEC AGO" (7.5s) → on "play" the pin morphs into a play button, "YOU PRESSED PLAY / 15 SEC AGO" (8.8s) → one pull-back from 2.4x to a 0.3x orbit view, "LAST LIGHT" and "GRAVITY" riding the ring (9.6-12.5s) → on "nothing" a dotted circle at the empty centre (13.4s) → on "hits" the darkness sweeps Earth in 0.7s, city lights pop on, the countdown turns gold at 0:00 (15.8s) → on "black" the background fades almost to black (17.4s) → Jupiter appears, "STILL SHINING FOR 1 HOUR+" (17.9s) → zoom out, a dashed tangent line, "30 KM/S" as Earth flies straight off (20.8s) → a thermometer counts 15 to -70°C while frost grows from the poles (22.8s) → a 0.8s rewind on a separate story clock (24.3s) → sunglasses drop onto the astronaut (25.2s) → a photon tagged "8:20 OLD", then the title (27.7s). For any other topic, keep the same shape: the event happens on its word, pull back to show scale, dive in to make it personal ("you"), pull back out, the consequence with a live counter, an escalation, a funny beat with the mascot, a callback and the title. </structure> <build> 1. One HTML file. Every frame is a pure function of time: window.seek(t) draws frame t. No timers, no CSS animation. 2. Camera moves on easeInOutCubic, zoom is interpolated in log space, every pop is a damped spring (damping .42-.5, frequency 12-16). 3. Voice: ElevenLabs eleven_v4 with a designed voice (calm, warm, curious male, late 30s, crisp, light neutral European English), stability .5, similarity .75, generated with timestamps. Without a key, use kokoro-onnx locally and get word times with faster-whisper. Every animation event fires on its word. About 165 words per minute, 0.24s between sentences, a 0.36s beat before the big reveal. 4. The darkness front: any pixel within the front's radius from the Sun turns to night with a 30px soft edge. The front moves at ~47px/s and ramps to 700px/s near Earth. 5. Keep two clocks: ambient time for twinkle, spin and bob, and a separate story clock for events, so a rewind stays consistent. 6. Render with Playwright in headless Edge with the GPU: seek every frame at 30fps and blend 2 subframes (shutter 0.6) for motion blur, then encode with libx264 at CRF 16 for the master and CRF 20 for delivery. 7. Sound: a calm royalty-free space music bed 7dB under the voice, timed so its natural ending lands on the title, swelling 5dB under the title. One downloaded royalty-free sound effect per event kind (collapse, impact, pull-back whoosh, countdown tick, dive, pin tap, photon land, play click, light hit, reveal, frost, rewind), each peak-aligned to its frame and 4-10dB under the voice. Master with gain plus a limiter to -14 LUFS, -2.2dB true peak. </build> <gotchas> Make the WebGL globe canvas at least 2 x radius x zoom x 1.18 pixels or the sphere clips flat in close-ups. Never draw prominences on the Sun's edge, they read as white hooks. Never pad the voice to fit the visuals, tighten the read instead. Speed the darkness front up near Earth or it takes 13 seconds to cross the planet. Show me a contact sheet of every beat before rendering. </gotchas> <start> Ask me the inputs, write the narration with the beat each word triggers, show it to me, then build and render the video. </start>

SpaceXSI is putting serious effort into Grok Bot for businesses, and the potential economic impact is really enormous SpaceXSI's internal Haggle Bot identified over $100,000 in savings in its first week by analyzing vendor contracts, unused software subscriptions and recurring purchases Now SpaceXSI is developing a specialized Haggle Bot for businesses, with the goal of improving enterprise cost efficiency by 5% or more At a global scale, Elon estimated this could translate into up to $6 trillion in annual savings when applied to global GDP And SpaceXSI is making the Grok Bots its own teams use available through its marketplace, allowing other businesses to benefit from the same technology This is where SI agents become incredibly valuable, going beyond answering questions to directly improving how businesses operate

Roadster event livestream nitter.siddz.com/i/broadcasts/1yKAPwNgg…

With the incoming Santa Ana wind event Thursday - Saturday, SCE is considering a PSPS for large sections of Santa Clarita Valley, Simi, Moorpark, Thousand Oaks and Malibu. The LFM levels in Ventura County are well below "critical" and historic levels. Be prepared and closely monitor @watchdutyapp and your local conditions. @Hotshot_Movie @spencerpratt

Assign Grok @Bot to your phone button for instant access

I truly believe this astroturfed attack on Shane Gillis is just another chapter in the ongoing war against provocative comedy. Every other form of art is as edgy and extreme as it's ever been, yet comedy is drowning in safe, watered-down, "children's entertainment for adults" pop comedy. People are attacking Shane Gillis, SiriusXM getting rid of Raw Dog Radio, the outrage over comedy roasts, the attacks from Elephant Graveyard, and the list goes on and on. Stand-up comedy is one of the last art forms you don't need banker money to produce. And who are the most censored people on the internet? Comedians and conspiracy theorists! The two groups that have led the charge in challenging Hollywood and the mainstream media. The energy inside a comedy club and the outrage on the internet couldn't be more different. People are laughing their asses off in the clubs while the dead internet attacks anyone who refuses to play ball. This isn't just about comedy. It's about controlling the narrative, policing free expression, and dictating what we're allowed to think, say, and laugh at in today's chaotic world. There is a war on your soul, and comedy is one of the last weapons we have to fight back!

🚨 BREAKING: Hundreds of federal agents -- FBI, DEA, ATF, U.S. Attorney's Office, and LAPD -- are SWARMING Skid Row right now in a massive drug bust 28 arrests expected. 44 search warrants. Large wads of cash, firearms, and fentanyI being seized on scene. Drug dealers are also being accused of specifically targeting people on the days their government checks arrive (of course) LONG overdue! Skid Row has been like a third world country for YEARS.

Imagine what you could do with an extra $11,000 a year. That's how much you'll save with me as governor. We pay more for gas, housing and taxes than anywhere in America. Ballots are out now. JUST TRY IT.