GIVEAWAY! 😍🎉 Don't miss your chance to win a pair of @STEMCELLTech science socks! 🧦 To enter, sign up to receive the latest research highlights in your field delivered to your inbox with STEMCELL Science News. 💌 🔗 Learn more: bit.ly/4sFyUzh

🤔The primary treatment for muscle-invasive and metastatic #BladderCancer is cisplatin-based chemotherapy, but chemosensitivity and severe toxicity severely limit its clinical application. In this Advanced Science (@AdvPortfolio) article, scientists synthesized MP-12C, a melatonin-conjugated platinum(IV) prodrug that remodels the ECM and enhances the sensitivity of bladder cancer cells to cisplatin! #OpenAccess🔗 bit.ly/3WBBDyt

This @ImmunityCP study found that #microglia exhibited acute and progressive morphological responses that preceded but paralleled ethanol-induced sedation. 📖 bit.ly/47jOSWW First authors Evi Paouri and Sarah Stanko show that genetic deletion of microglial Myd88 protect against ethanol-induced microglial reactivity, neuronal damage and dysfunction, intoxication, and motor impairments by preventing #ECM disruption.

Using temporal multi-omics, biomechanical profiling, and spatial fate mapping in #colitis models, @WeizmannScience researchers showed that colonic #ECM underwent lasting pathological reprogramming following inflammation. 🔎 bit.ly/3VL0FuQ Their findings, published in @ImmunityCP, redefine the ECM as a long-lived instructive compartment that encodes injury memory and promotes maladaptive regeneration.

Fibrosis across kidney, bone marrow, intestine, heart and cancer: Fibrosis Frontiers: From Basic Mechanisms to Precision Therapies. Scholarship & short talk abstracts due Nov 4. Join @KeystoneSymp in Keystone, CO, Mar 1–4. #KSFibrosis27 hubs.la/Q04z9fV30

Investigators profiled primary tumor tissues using spatial #transcriptomics and identified a fibroblast-associated #ECM remodeling niche associated with metastatic status in KRAS G12C-mutant #LungAdenocarcinoma. bit.ly/4ynYNG8

This #OpenAccess review provides an overview of the state of the art of #ExtracellularMatrix components and function in the central nervous system, both under homeostasis and in #neurodegeneration. 🧠 Give it a read: bit.ly/4yDGmhh

This work identified epithelial #senescence-associated signaling as a mechanism linking prostate epithelial alterations to fibroblast reprogramming and #ExtracellularMatrix remodeling. Check out the #OpenAccess paper. 👇 bit.ly/4eha8jI

In lesional skin, extracellular matrix remodeling provides a complementary framework for understanding psoriasis as a disease involving both immune activation and persistent tissue-level remodeling. Read the full paper: bit.ly/4jzmszh Led by researchers at Hubei Province & Key Laboratory of Skin Infection and Immunity and Huazhong University of Science and Technology. #Psoriasis #Dermatology #Immunology

Tumor-derived lysyl oxidase–like 4 stiffens the extracellular matrix, triggering a mechanotransduction-to-epigenetic pathway that induces CD8+ T cell exhaustion in lung cancer. Read the study: bit.ly/4AKU43I Led by first author Xuyu Gu at Shanghai Pulmonary Hospital and corresponding authors William C. Cho at Queen Elizabeth Hospital and Qiyu Fang at Tongji University. #LungCancer #Immunotherapy #TCellExhaustion

This year’s Party with a Purpose, an annual philanthropic gala to support the American Association of Cancer Research (#AACR), will recognize Dr. Robert Vonderheide, the Scientific Achievement Honoree, and Dr. Andrew Rech, who was nominated by Vonderheide, as the Early Career Investigator Honoree, for their achievements and continued efforts to drive new cancer immunotherapy advances. 🙌 Read the article here! bit.ly/4rzynPM

Investigators developed an accelerated #immunomodulatory matrix reservoir integrating methylgermanane nanosheets within an active Ca2+-crosslinked alginate hydrogel. ✨ 🔗 bit.ly/4yctMp0

Dr. Di Zhao and researchers reported that B7-H3 plays dual roles in regulating #MDSCs and cancer-associated fibroblasts (#CAFs), thereby promoting tumor progression and therapy resistance, respectively. 🔬 Learn more: bit.ly/4hjG87z

Aberrant tubular epithelial cell and immune-cell activation converges in the sustained activation of fibroblasts and the deposition of excess extracellular matrix, driving the progression of acute kidney injury to chronic kidney disease over time. Read the @nature study: go.nature.com/3SQAWjD Led by researchers at Helmholtz Zentrum München and Ludwig-Maximilians-University in Germany. #Nephrology #KidneyDisease #Fibrosis

A new review synthesizes mechanistic insights linking cathepsin D-mediated proteolysis to epithelial junction reorganization and permeability barrier recovery. It also highlights emerging therapeutic strategies for improving chronic wound healing. Read the review: bit.ly/4AgI1dS Research from Adichunchanagiri University, led by first author Shobith Rangappa and senior author Manjula Rv. #WoundHealing #Dermatology #CellBiology

Challenging the prevailing fibroblast-centric paradigm, investigators provide an overview of how non-fibroblast cell types engage in dynamic crosstalk and collectively shape the biochemical and biomechanical landscape of tumors. Led by first author Sonal Srivastava and corresponding author Antonio L. Amelio at Moffitt Cancer Center Tampa. Check out the full review here: bit.ly/4xmMs4j #ECM

Researchers discussed #epigenetic mechanisms controlling cancer cell-intrinsic states, cancer cell–TME crosstalk, current epigenetic therapies, and future research directions that may lead to the discovery of new biomarkers and the development of effective epigenetic anticancer therapeutics. ▶️ Check out this #OpenAccess review: bit.ly/3SAouEA

Dr. Morten Thaysen-Andersen and researchers reported on the mechanistic basis for and functional consequences of glycocalyx remodeling accompanying tumor-associated #macrophages polarization. Learn more: bit.ly/4cza9Pm

Emerging evidence indicates that diverse non-epithelial cell populations undergo a progressive reprogramming toward mesenchymal-like states during tumor progression. This review names this phenomenon #mesenchymal drift and underscores its significance for next-generation therapeutic strategies: bit.ly/4wLazcu

#LiverFibrosis is sustained by the dense #ECM produced by persistently activated hepatic stellate cells (aHSCs). In this study, researchers developed an aHSC-targeted nanoplex that disrupts the rigid ECM, offering a promising antifibrotic therapy: bit.ly/4qBOR9v

🤝 Single-nucleus transcriptomics meets single-cell transcriptomics in this new @CellStemCell paper that identifies stromal reprogramming as a mechanism governing hematopoietic niches. Take a look at the #OpenAccess paper: bit.ly/4zRb1cb #Myelofibrosis