Cutting-edge research in immunology from around the world. This account is no longer monitored, and content is automated. Join us on LinkedIn!
Cambridge, MA, USA
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Embracing macrophage complexity for research and translation. cell.com/immunity/fulltext/S… @ImmunityCP
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Spotlighting the macrophage cells in our blood and tissue, their role in diseases, and targeted interventions
cell.com/immunity/fulltext/S… @ImmunityCP
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What comes after M1/M2? In our Perspective with @FGinhoux in @ImmunityCP we explore how single-cell technologies and AI can decode the gene programs macrophages use across tissues & microenvironments, and how this modular view could transform immunotherapy
cell.com/immunity/abstract/S…
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This @ImmunityCP study found that #microglia exhibited acute and progressive morphological responses that preceded but paralleled ethanol-induced sedation.
📖 bit.ly/47jOSWW
First authors Evi Paouri and Sarah Stanko show that genetic deletion of microglial Myd88 protect against ethanol-induced microglial reactivity, neuronal damage and dysfunction, intoxication, and motor impairments by preventing #ECM disruption.
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Online now: Embracing macrophage complexity for research and translation dlvr.it/TVxZsp
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Online now: Lactate dehydrogenase A-dependent redox control of selective mRNA translation directs monocyte fate commitment dlvr.it/TVwwlg
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Using temporal multi-omics, biomechanical profiling, and spatial fate mapping in #colitis models, @WeizmannScience researchers showed that colonic #ECM underwent lasting pathological reprogramming following inflammation.
🔎 bit.ly/3VL0FuQ
Their findings, published in @ImmunityCP, redefine the ECM as a long-lived instructive compartment that encodes injury memory and promotes maladaptive regeneration.
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Can our immune system remember a virus for 20 years? Prof. Zhang Linqi’s Innovative Tsinghua team @MedTsinghua found that SARS-CoV-1 immune memory can endure for two decades in @ImmunityCP, providing new insights for broader vaccines with @HKUniversity and other collaborators.
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Unraveling the immune system's role in our healthspan
Breaking down a seminal study just published @ImmunityCP
erictopol.substack.com/p/a-t…
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Online now: Skin-resident CXCR6+ memory CD4+ T cells and dendritic cells form dermal perivascular hubs that drive relapse in allergic dermatitis dlvr.it/TVtT2v
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Induced regulatory B cells stably expressing interleukin-10 reverse central nervous system autoimmunity by targeting myeloid cells. @ImmunityCP cell.com/immunity/fulltext/S…
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Out in @ImmunityCP : We expanded to >2,500 TCRs and 8 epitopes and find that ~half of TCR-pMHC pairs do not validate. On clean data, we show that modeling reactivity with AF3 & tcrdist3 is more feasible than assumed. Is your model better? Join IMMREP26! 🧵
cell.com/immunity/fulltext/S…
It's not the models, it's the data!
We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.🧵
biorxiv.org/content/10.1101/…
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A seminal paper on aging of our immune system was just published. From study of over 12 million single-cells in 8 cohorts, >2,600 individuals, ranging in age from 18 to 98. Yielding a practical blood test. And much more.
A Tale of Two T cells
In the new Ground Truths
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CD8+ Tem GZMK+ to GZMB+ ratio distinguishes healthy from disease-associated trajectories and predicts mortality risk @ImmunityCP
cell.com/immunity/fulltext/S… @maxim_artyomov @WashU @nikart89 @NationwideKids @KingsCollegeLon
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Lymph node lymphangiogenesis encapsulates activating germinal centers to constrain their size, which enhances clonal selection and protective antibody responses @ImmunityCP
cell.com/immunity/fulltext/S… @nyugrossman @theLundLab
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Microglia-mediated extracellular matrix disruption drives neuronal dysfunction, motor impairments, and sedation following alcohol abuse. @ImmunityCP cell.com/immunity/fulltext/S…
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A remarkable study of 12 million single-cells (RNAseq) from 8 cohorts plus proteomics to determine the immune cells linked to healthy aging. Major findings included:
—thymic involution is central (decline in naive T cells and thymic emigrants)
—elevated immune system activation, inflammaging
—CD8+ memory cells (GZMB+) high frequency
—CMV seropositivity and chronic disease
@ImmunityCP by @maxim_artyomov and colleagues
cell.com/immunity/fulltext/S…
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💡 What sets the size of a germinal center? — why lymphatics of course 😉
Our new study with Carla Nowosad reveals how lymphatic remodeling constrains germinal center growth and shapes the quality of the antibody response. @ImmunityCP @nyugrossman
cell.com/immunity/fulltext/S…
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