A Tweetorial – Does PHOTOdynamic Surgery in Non–Muscle-Invasive Bladder Cancer reduce recurrence?

Congratulations to ELIPSE for turning 2 years old. Thank you to everyone that has supported ELIPSE along the way!! @Krish_Narahari, @jonathananing, @Heer_Lab, @vishhanchanale, @benchallacombe, @BURSTurology

Congratulations to Cardiff for meeting and exceeding their recruitment target for ELIPSE!!🥳🎉 @Krish_Narahari, @jonathananing, @Heer_Lab, @vishhanchanale, @benchallacombe

Our @Nature paper is out! It's been known for a while that long-term dietary habits can affect how our immune system behaves. But what about much briefer changes in diet? In mice, we found that even a few days of dietary change (think cheat days...or perhaps salad Sundays) at the onset of inflammation can profoundly alter disease severity and establish lasting inflammatory memory in tissues, even after the diet changes back. nature.com/articles/s41586-0… This work was led by two extraordinarily dedicated and inexhaustible members of our lab: former graduate student @OwenJ457 and former technician John Tayeri. It was also an exercise in collaborative science as many labs @UCSF and @Stanford came together to bring this over the finish line - special thanks to @gardnerlabUCSF, @Molofsky_lab, @alexis_combes, @Treg_Mike. Deeply grateful to everyone who contributed!

何と！ ｢カラスはサルや人間よりも速く意思決定を行う｣ Science ･ カラスが画面の点の動く方向を判別 ･ 人・サルの過去研究の約半分の時間で反応 ･ 正確さも保ち、脳は約70msecで選択を反映 ･ 構造の異なる鳥の脳から、高速な意思決定の仕組みを探る手がかりに science.org/doi/10.1126/scie…

In the latest issue! Gut microbiota generate dinitrosyl iron complexes with cardiometabolic benefits dlvr.​it/TW7RxV

A stress-adapted fiber state promotes clonal expansion of deleted mitochondrial DNA cell.com/cell-reports/fullte…

This is an important release in @JCO_ASCO in conjunction with #ESMO26 #DASL HiCaP trial. Identifying pts who benefit the most from intensified treatment is a work in progress. @ASCO @myESMO @ChrisSweens1 #ENZARAD @Prof_IanD et al. @OncoAlert ENZARAD (ANZUP 1303): Phase 3 Trial of Enzalutamide With Androgen Deprivation Therapy and Radiation Therapy in High-Risk Localized or Locally Advanced Prostate Cancer | Journal of Clinical Oncology ascopubs.org/doi/pdf/10.1200…

🚨 ENZARAD (ANZUP 1303): 2 years of enzalutamide did not improve metastasis-free survival when added to RT + ADT in high-risk/locally advanced #prostatecancer 🚨 @JCO_ASCO 👥 802 pts, high-risk localized or locally advanced PCa (incl cN1) 📊 Open-label phase 3 RCT, definitive prostate RT + 24 mo ADT 💊 Enzalutamide 160mg daily x24 mo vs older NSAA x6 mo ⏱️ Median f/u 92 mo ✅ 8-yr MFS on conventional imaging 74% vs 72%, HR 0.88 (0.67-1.15), P=0.34, not significant ✅ No OS benefit ✅ Prespecified subgroup w/ planned pelvic nodal RT (n=324): HR 0.47 (0.29-0.76), Padj=0.004 ⚠️ Subgroup signal is hypothesis-generating; grade 3-5 AEs 46% in both arms 🎯 Enzalutamide on top of RT + 2 yr ADT did not improve outcomes overall, potential signal with pelvic nodal RT subgroup 🔗 doi.org/10.1200/JCO-26-01794 @urotoday @UrologyTimes @PCF_Science @SbrtSean @ChrisSweens1 @Prof_IanD @UroOnc @SUO_YUO

Out now in @TheLancetOncol: biomarker data from TALAPRO-2 (Enza+/Tala) in mCR #ProstateCancer Key data: 1. 81% concordance b/w ctDNA & tissue 2. Baseline ctDNA- & CTC0 strongly prognostic 3. Conversion of ctDNA & CTC at wk 9 strongly prognostic. Link 👉 rb.gy/347dc4

Nature research paper: Genetic variants shape single-cell chromatin accessibility and disease risk go.nature.com/3USoMri

“E-cigarettes with no further support were more effective than supportive messaging [in helping people achieve abstinence from smoking]. E-cigarettes with multisession telephone-based support were more effective than e-cigarettes alone.” Learn more: eviden.cc/48hvH0c

膵癌の免疫回避が局所的なのかシステミックかを検討、腫瘍由来のSERPINE1及びSERPINB2が局所的に免疫抑制的なニッチ形成に働いていることを明らかにした論文。腫瘍の中でも境界に近い細胞がこれらを発現、間質を線維化、MΦからの免疫抑制を誘導するらしい。Nature。 nature.com/articles/s41586-0…

Premature birth may do more than interrupt brain development—it may fundamentally alter how the cerebellum matures into early childhood, according to a new study in Science. The findings reveal how the timing of birth shapes brain cell development and neural connections, offering new insight into the lasting neurodevelopmental effects of prematurity. 📄: scim.ag/47OzVMI #SciencePerspective: scim.ag/4yLJRkY

🧵 #ESMO26 prostate cancer highlights- my personal summary @urotoday:
1️⃣ Very high-risk localised: DASL-HiCaP & the ARPI class question
2️⃣ mHSPC: PEACE-1, CAPItello-281 OS + PSA >0.2: intensify or de-intensify? 
3️⃣ mCRPC: PROMPT, ctDNA vs tissue
4️⃣ NE PCa: KEYNOTE-365 1/5

Discovery of 48 new, common genomic loci (a ~60% jump) associated with Alzheimer's disease. A high proportion of the new loci are tagged to brain immune cell (microglia) function @Nature nature.com/articles/s41586-0…

Truly honored and humbled to receive the FASCO distinction from @ASCO Through different institutions, ASCO has been a constant throughout my oncology journey, giving me opportunities to learn, serve, collaborate, and contribute to advancing cancer care. Deeply grateful for the opportunities to serve ASCO and excited to continue giving back 🙏 @CleClinicMD @caseccc

Scientists including Yuhu Niu and Jiangli Yang summarize the generation and application of #hiPSC-derived brain #organoids for ALS research, with a focus on the reconstruction of neural circuits, multi-omics profiling, and functional assays. 🧠 Check it out: bit.ly/47R8imd

🚨NEW PUBLICATION🚨 IB1-LASERCOMPLETE live in @BJUIjournal! @TUF funded prospective feasibility study in bladder cancer: 👉 Can FCM help detrusor muscle detection in TURBT samples 📄 Read it free: doi.org/10.1111/bju.70395 Thank you to the funder, all co-authors and the patients!

Congratulations to the team at Norfolk and Norwich for reaching their ELIPSE recruitment target! 🥳🎉 @Krish_Narahari, @jonathananing, @Heer_Lab, @vishhanchanale, @benchallacombe, @BURSTurology, @NNUH

Congratulations to wonderful team at The Christie for reaching their recruitment target!!