Finally online - sharing our findings that #Lyme disease bacteria can live in female reproductive organs for over a year and increase risk for gynecological disease!!! We found this increased risk in mice and humans! 😱 (thread below) medrxiv.org/content/10.1101/…

Sounds like the big prizes for TOPx will be announced tomorrow! Thank you all for your efforts! Meanwhile, check out the newest video short from my awesome student Caleb explaining capillaroscopy with blood flow in 32 seconds!!! I'm so impressed @MIT_TRG piped.video/shorts/Mi8mxzF3Q…

A small molecule improves the fitness of cells containing diseased mitochondria. Learn more in a new #SciencePerspective: scim.ag/4jOhL50

2/ The puzzle: CD19-CAR T cells produce sustained drug-free remission in severe autoimmune disease. Antibodies against the same B cell lineage rarely do. Both deplete B cells. So what does CAR T remove that antibodies leave behind?

CD19-CAR T cells clear the EBV-infected B cells that carry autoreactive antibodies. Rituximab doesn’t. That may be why only one of them produces lasting remission. New Robinson Lab preprint led by me and @panditmahes. 🧵 biorxiv.org/content/10.64898…

Stanford researchers studied 27 autoimmune patients and found CD19 CAR T-cell therapy cleared EBV-infected, autoreactive B cells that resisted rituximab. 8 of 12 CAR T-cell patients achieved sustained drug-free remission. biorxiv.org/content/10.64898…

🚨 New preprint alert 🚨 Using our developments in multispectral imaging we ask: how does the organelle network rewire in killer T cells as they kill cancerous target cells? 🧵

I am so incredibly grateful for the NIH funding for our endometriosis NAMs Technology Development Center, where we are working with industry partners to move new EFFECTIVE endometriosis drugs into the clinic. It is my dream of decades, to help women and girls avoid the horrible pain and other gross symptoms I endured, by bringing new targeted therapies into the clinic.

Voting for TOPx closes on Thursday, so cast your votes now!!! invisibleillness.crowdicity.… In the meantime, look at what happens when we cut off blood flow under a capillaroscope! piped.video/shorts/Mi8mxzF3Q…

Headed to RECOVER TLC with a suitcase full of Vagis rings! 2nd rings for @doc4care @NovaSupport and Isabel to run experiments with rings on both hands, some for @ImmortalSaKe and Dr Yellman, and two are headed to @ImmunoFever. Isabel is also bringing a capillaroscope that she got from Mikki and we have Lumias and my whole stack of wearables and devices. We're going to have to take over a table at the meeting to show everyone all the gear. 😆 @BrainstemMd

Sustained low-level #inflammation is a hallmark of the #aging process. The accumulating damage persistently activates the innate immune system - the body’s first line of defense - leading to what is known as inflammaging, functional decline and chronic diseases of old age. Unlike the adaptive #immunesystem, which switches on and off based on the specific pathogens it recognizes, innate immune sentinels such as macrophages can recognize a diverse array of danger signals. The mechanism of this pattern recognition has remained an enigma, however. In a new study published Oct. 23 in Cell, researchers at Yale School of Medicine found that the amino acid #taurine is key to the way the innate immune system senses danger signals. Even more, boosting taurine levels may diminish the effects of inflammaging. Read more here: medicine.yale.edu/news-artic…

Hi everyone, we’ve been working on something 🙏🏼 I’ve written a second letter to Andy Burnham, alongside 360 sports people, to urge him to meet with me and fund research into my much neglected health issue which impacts millions of others. I can’t believe 360 people signed in just 1 week, so many amazing names and messages still coming in of people wanting to add theirs (so feel free to message to add yours, we’re keeping on the pressure!!!) The list includes 114 Olympians, with 77 medals between them (and that’s not even including Worlds and Europeans 🤯). Also some huge names from football and many other sports!! Thank you SO much to everyone that signed, I can’t tell you how much it means to me when I’m truly at rock bottom ❤️❤️❤️ I know everyone wants their issues taken seriously, but this has been neglected like nothing else. WE HAVE 0 APPROVED TREATMENTS!!! Please listen 🙏🏼 @andyburnham @number10gov @UKLabour @DHSCgovuk

Interessante Studie, die in einer sehr selektionierten Population mögliche Ursachen für den immer wieder berichteten Thoraxschmerz bei ME/CFS herausarbeitet. Auch die reduzierte periphere Sauerstoffextraktion konnte im iCPET gezeigt werden. journals.physiology.org/doi/…

A new @ScienceAdvances study proposes the Bacillus Calmette-Guérin vaccine as a preventative measure against dementia. The vaccine reduces Alzheimer’s-associated phospho-tau proteins, reprograms myeloid immune cells and limits neuroinflammation. scim.ag/47Dk9nR

Thought provoking slide. Has me ponder if mitochondria are central to many diseases. A conductor of the orchestra of immune cells.

argh I meant to add this to my retweet... There's another issue here. The standard scientific method is totally focused on weeding out the bad hypotheses - "ruling out", strong inference, etc. We are amazing at teaching the part where we get rid of the bad candidates. We never teach the generative input part: where do the good hypotheses/candidates come from? How to make sure the set you're winnowing actually contains the great ideas too? This just like how we teach evolution: most effort is spent on the selection part - what dies off. How do we make sure the good variants are in the pool to begin with? Andreas Wagner's "Arrival of the Fittest" is a good book on that. Back to science: The thing is, the ruling out part is algorithmic - that's the scientific *method* and thus we can teach it. Even that's hard, there's a lot of intuition needed there too, but at least the algorithm exists. The other part, having the good ideas to even start testing, is not algorithmic. I don't think it can be taught. Because, I don't think we create the good ideas, the way we mechanically subject them to tests. We *facilitate* them. Many impressive creatives have written stories, of how they interact with, not meticulously micro-construct, the big ideas. So I don't think we can teach it the same way we teach the scientific method per se, but we can absolutely do better in helping our mentees with maximizing it. I have my own crazy idea of what's up with inspiration (piped.video/k9lGNyPHurQ) and I think it goes all the way down and sideways (it's not just for humans/scientists or even biologicals), but regardless of that, we all ought to be thinking of ways to enhance the best practices for ourselves and our trainees to have the big ideas and give them room to breathe. Perhaps some will find something useful here: thoughtforms.life/what-advic….

Can simply standing up make your kidneys leak proteins? Surprisingly, yes. Orthostatic proteinuria is an example of how gravity, renal haemodynamics and vascular anatomy can influence glomerular filtration without necessarily indicating kidney damage.

ashpublications.org/blood/ar… MDS is not a disease of accumulated mutations. It starts when mitochondria decide to reprogram stem cell fates. And I’ve said so many times MDS is your human aging model.

I hope it was a Happy Halloween and that you weren't out there TICK or TREATING! Do a tick check on yourself and the kids just in case! Tis the season when I'm getting sent pics of embedded ticks with Q's of what to do. Pull it out fully and send for testing!

Did you walk through leaf piles and lawns last night trick or treating? Make sure you weren't TICK or TREATING! Do a quick tick check (you and the kids)! Tis the season when I'm getting sent pics of embedded ticks with Q's of what to do. Pull it out fully and send for testing!

I am in the middle of another cluster of desperate requests for support from people with #longcovid or #mecfs from all over the world. I will try to find a spot for everyone. However, this is becoming a big crisis. IF you are a doctor seriously caring for these patients out of Italy - meaning to formalize diagnosis, offer diagnostic approach and comprehensive care and followup including off label treatments - and want to collaborate contact me. While I am happy to support everyone, many times I can only provide my full support if a patient has a collaborative local doctor that is happy to discuss with me and, if in agreement, prescribe and monitor. Many countries will not accept italian prescriptions, and even if so, local monitoring for progress or side effects require local doctors.