Let's Win Pancreatic Cancer plays a critical role in getting research to patients, to transform outcomes. 💜

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Nuevos tratamientos están dando razones para tener esperanza frente al cáncer de páncreas. Acompáñenos en el seminario web Let’s Learn con el Dr. Arturo Loaiza-Bonilla (@DrArturoAI) y Catalina Fandino. Jueves 29 de oct., 2 p. m. ET 💜 Regístrese: us02web.zoom.us/webinar/regi…
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Brian Tayman calls his wife, Lisa, “the toughest person I know.” After her pancreatic cancer diagnosis, he became her caregiver and leaned on other caregivers and family when he was struggling, too. 💜 piped.video/fHQOfMnUD1Y
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Let's Win Pancreatic Cancer 💜 retweeted
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies. In @LancetGastroHep, a Review evaluates the clinical development of therapeutic cancer vaccines in PDAC: spkl.io/60107kQ3K
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As a nurse, Lisa Tayman knew pancreatic cancer. Then it became personal: a pancreatic neuroendocrine tumor in 2019, a recurrence in 2023, a tough recovery, and later, a half-marathon. Today she’s focused on the future with her young family. 💜 piped.video/G0UzeU3xjcI
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Next up in our “Why I'm Running” series: Bethany. Bethany is running the @nycmarathon in place of her Uncle Yale, who was diagnosed with stage 4 pancreatic cancer in 2023. Support Bethany's run: letswinpc.org/fundraisers/20…
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#ESMO26 Day 1 highlight for me: MASTERPLAN, now in Lancet Oncology. Radiation and pancreatic cancer have a complicated history. ESPAC-1 suggested adjuvant chemoradiation hurt. LAP07 and CONKO-007 couldn't show an OS benefit after chemo. A021501 closed its RT arm for futility. PREOPANC-2 was a draw. We walked through the adjuvant side of this story in Sem Rad Onc last year: doi.org/10.1016/j.semradonc.… So why is MASTERPLAN different? Phase 2, 14 sites in Australia and NZ (can i just say I love the Aus-NZ studies). 74 patients with high-risk localized PDAC, randomized 2:1 to chemo ± SBRT 40 Gy/5 after induction. 12-mo locoregional recurrence 20.2% vs 52.0%, sHR 0.44, p=0.022 
PFS 11.9 vs 6.3 mo, HR 0.44 
OS 22.0 vs 14.0 mo, HR 0.45 
Grade ≥3 AEs 70% vs 64%. Why did this one work when others didn't? The rad oncs can explain the physics better than I can. I just read it as better tumor zap zap. Does it change practice? Maybe. I think we need to have a deeper conversation at every tumor board, but the juice seems worth the squeeze. @OncoAlert @TheGutOncLab @Onco_Nexus sciencedirect.com/science/ar…
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On the latest episode of PancChat, host @AlisynCamerota is joined by Dr. Diane Reidy-Lagunes of @DukeHealth to discuss managing pancreatic neuroendocrine tumors, also known as PNETs. Visit 🔗 pcan.at/PancChat to listen. The PancChat podcast is a collaboration between @LetsWinPC and PanCAN, and this episode is sponsored by @RevMedicines. 💜
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A new dawn for pancreatic cancer is emerging. Two big approvals this year, multiple promising agents in trials, and now impressive early results with this combo. We still have a long way to go, but the momentum is real. More reasons for hope than ever. #ESMO26 @PanCAN @letswinpc
Tango reports 82% tumor response rate in trial of combo therapy (Daraxonrasib plus vopimetostat) for advanced #PancreaticCancer at #ESMO26 statnews.com/2026/10/23/esmo… Reduced toxicity data is particularly important as a lower Daraxonrasib dose can be used.
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Phase III RASolute 302: Daraxonrasib Across Key Subgroups in Metastatic Pancreatic Cancer At the ESMO Congress 2026, Zev A. Wainberg presented additional exploratory subgroup analyses from the Phase III RASolute 302 trial (LBA82), evaluating daraxonrasib versus standard-of-care chemotherapy in previously treated metastatic pancreatic ductal adenocarcinoma (mPDAC). Key findings: 🔹 Overall OS (primary analysis): 13.2 vs 6.7 months (HR 0.40; 95% CI 0.30–0.53). 🔹 RAS genotype: OS hazard ratios numerically favoured daraxonrasib across evaluated subgroups, including patients without an identified tumour RAS mutation. 🔹 Preselected chemotherapy regimens: OS HRs ranged from 0.32 to 0.46. 🔹 Prior treatment setting: OS HR was 0.36 (95% CI 0.17–0.75) for early metastatic recurrence following perioperative therapy and 0.43 (95% CI 0.32–0.58) after one prior line of metastatic therapy. Takeaway: Exploratory analyses showed directionally consistent OS outcomes favouring daraxonrasib across clinically relevant subgroups. Findings in smaller mutation-defined subgroups require cautious interpretation due to limited sample sizes and wide confidence intervals. @MiteshBorad @FilippoPietran4 @ChiaraCrem1 @oncodaily @myESMO oncodaily.com/gastrointestin… #ESMO2026 #RASolute302 #OncoDaily #ESMO26
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About 10% of pancreatic cancer patients have neuroendocrine tumors (PNETs). How are they different? Dr. @DianeReidyLagun of @DukeHealth joins @AlisynCamerota on #PancChat to explain diagnosis, treatment, and why expertise matters. 🎧 piped.video/zSltAxo1w0M
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PancChat is a collaboration between Let's Win and @PanCAN, available on all major podcast platforms.
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Next up in our "Why I'm Running" series: Michael. He's running the TCS New York City Marathon in honor of Dr. Marta Rendón, who passed away from pancreatic cancer and was the mother of his close friend Juan Pellerano-Rendón. . Support Michael's run: bit.ly/4yxtBnB
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Beyond excited to recruit @VivekSubbiah to @nyulangone @Perlmutter_CC as the new director of our Early Phase Drug Development Program and the Rare Cancer Program. Congratulate Vivek when you see him at #ESMO26. Welcome to NYC! @JohnPLeonardMD nyulangone.org/news/perlmutt…
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When Cancer Calls an Audible: After a pancreatic cancer diagnosis upended his life and career, one survivor reflects on treatment, resilience, and finding hope more than a decade later. via @cure_today curetoday.com/view/when-canc…
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Nuevos tratamientos están dando razones para tener esperanza frente al cáncer de páncreas. Acompáñenos en el seminario web Let’s Learn con el Dr. Arturo Loaiza-Bonilla (@DrArturoAI) y Catalina Fandino. Jueves 29 de oct., 2 pm ET 💜 us02web.zoom.us/webinar/regi…
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