The Human Protein Atlas is an #OpenAccess resource for human proteins. Search for specific genes/proteins or explore the 12 different sections.
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At HUPO 2026 in Singapore, Loren Méar presented research investigating how the tumor microenvironment may contribute to chemotherapy response in high-grade serous ovarian cancer.
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Podocytes are specialized epithelial cells of the glomerulus, the main filtration unit of the kidney. Microtubules in the podocyte are vital to its function and here microtubule associated protein MAP6 is highlighted in glomeruli.
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Breast cancer is the most common cancer among women worldwide with more than 2 million new cases diagnosed each year. The cancer develops in the mammary gland with invasive ductal carcinoma (IDC) being the most common type accounting for 80% of the cases.
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Changes in metabolic pathways are frequently seen in cancer cells, and mutations in certain metabolic genes may even play a direct role in cancer development and progression. One gene for which this is true is the multi-localizing gene FH.
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The protein FATE1 is abnormally expressed in many cancer types and using mIHC/IF it is shown to localize (green) to the cytoplasm (red) and nucleus (magenta) of Sertoli cells that support the developing sperm cells in testis.
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The expression of PDX1, the transcription factor regulating development of the pancreas and expression of insulin in beta cells in the islets of Langerhans, is shown to localize (green) to the nucleus of beta cells (magenta) using mIHC/IF.
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Current therapies inadequately target T-cell pathways in autoimmune and inflammatory diseases limiting disease control. In a recent publication a novel, targetable transcriptional-metabolic axis that sustains inflammatory T-cell responses is identified.
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A Protein Sci article presents the HPA Multiplex tissue resource, with 1,106 proteins analyzed across eight antibody panels. Mapping proteins to cell types, cell states, and tissue structures give deeper insights in protein expression in human tissues.
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A protein in the wrong place can be catastrophic
ALS is associated with high morbidity and early mortality. It has turned out that redistribution of the protein TARDBP from the nucleus to the cytoplasm in multiple brain cell types is part of the process.
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A recent study investigated early changes in ovarian cancer. In this interview Fabian Coscia and Mihnea-Paul Dragomir discuss how the team moved from spatial proteomics discovery to tissue-based validation using an antibody against DHCR7.
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A study in PNAS describes how hypoxia and elimination of peroxisomes drives HCC dedifferentiation. RNF126 is identified as an inducible switch that determines peroxisomal fate and links the hypoxic microenvironment to loss of hepatocyte differentiation.
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Saliva is a combination of enzyme-rich secretions from serous acini and mucin-rich secretions from mucus acini. Using mIHC/IF the regulator of acinar cell functions BHLHA15 (green) is shown in the nucleus of serous acini (cyan) within the salivary gland.
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Mitochondria go where they are needed
Mitochondria do a lot more than ATP production. The positioning of mitochondria within cells is regulated and dynamic and their direct interaction with other organelles can regulate many cellular processes.
Read more
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Transcription factor FOXJ1 (magenta) and chromatin regulator HMGN3 (green) display different nuclear staining in the fallopian tube. FOXJ1 stains a subset of the cells in the fallopian tube epithelium while HMGN3 shows a more general staining pattern.
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A Nature study suggests ALDH18A1 and ferroptosis as a therapeutic target for cancer treatment. Inhibition of ALDH18A1 suppressed livercarcinogenesis through depletion of spermine (essential for cellular homeostasis) and activation of ferroptosis in HCC.
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In this episode of Proteins Unfolded Evelina Sjöstedt, head of HPA Single cell analysis talks about the transcriptome in the context of the genome and proteome. She discusses her current research at The Human Protein Atlas and single cell transcriptomics.
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In the Episode 82 of of the Proteomics show podcast series "Alt Proteomics" HPA researcher Dr Cecilia Lindskog talks about the importance of proteomics data integration together with the hosts Benjamin Neely and Ben Orsburn.
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Glycolysis-associated enzyme PKLR highlighted in cytoplasm of proximal tubular cells (green) in the kidney using multiplex immunohistochemistry. Other kidney structures shown are Distal tubules (red), podocytes (yellow) and endothelial cells (magenta).
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Human Protein Atlas retweeted
5/5 All data is integrated into @ProteinAtlas alongside matched RNA: proteinatlas.org/humanproteo…
Shout out to Mathias Uhlen, @CarolineWeiss30 & a wonderful Munich–Stockholm collaboration 🇩🇪🇸🇪
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In version 25.1 of the Human Protein Atlas, a dataset based on Deep Visual Proteomics has been integrated in the Single Cell resource to provide mass-spectrometry based proteomics at an unprecedented resolution across cell types and tissues.
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