Tenure Track Assistant Professor @Aarhusuni (Denmark). Pancreatic cancer metabolism, iron and nucleotide metabolism. All opinions are my own
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Excited to share our latest story @NatureComms. Here, we used quantitative proteomics, metabolomics and in vitro/in vivo CRISPR screens to define mechanisms of resistance to DHODHi in PDAC and propose combinatorial approaches with BCL-XL inhibitors:
nature.com/articles/s41467-0…
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SantanaCodina lab retweeted
RESEARCH | @apoptosislab et al (@idibell_cat)
Glucose deprivation triggers the secretion of the cytokine #LIF, which promotes #angiogenesis and #immune suppression in lung #cancer models
nature.com/articles/s42255-0…
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AI is cool and all... but a new paper in @ScienceMagazine kind of figured out the origin of life?
The paper reports the discovery of a simple 45-nucleotide RNA molecule that can perfectly copy itself.
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Excited to share our latest work out today in @MolecularCell, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Congratulations to first author @MushtaqNengroo! sciencedirect.com/science/ar…
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Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins. nature.com/articles/s41586-0…
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Super excited to share our new preprint from @ColinSh21573670 on how the tumor microenvironment causes drug resistance in pancreatic cancer: biorxiv.org/content/10.1101/…
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New discovery from our team defining how human brain cancers rewire the metabolism of the normal brain published today @Nature and led by @AndrewScottPhD nature.com/articles/s41586-0…
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Excited to share our latest story @NatureComms. Here, we used quantitative proteomics, metabolomics and in vitro/in vivo CRISPR screens to define mechanisms of resistance to DHODHi in PDAC and propose combinatorial approaches with BCL-XL inhibitors:
nature.com/articles/s41467-0…
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Finally, we validated this combination in several in vivo models of PDAC and in human PDAC organoids. We propose combinatorial targeting of DHODH and BCL-XL as a therapeutic strategy with potential therapeutic translatability in PDAC.
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This project started during my time as a postdoc in the Mancias lab and it would not have been possible without @ManciasLab and Huan’s incredible efforts to bring this to completion. Thanks also to our collaborators and to postdoc Marina Ciscar in my lab.
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SantanaCodina lab retweeted
A jobs bonanza from @michiganstateu @HenryFordHealth hiring TEN cancer researchers!
henryfordmsu.infoready4.com/…
Applicants focused on pancreas, brain, lung, breast, ovarian, prostate, and hematological cancers are especially encouraged to apply.
Please share!
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Job offer! We are looking for a motivated postdoctoral researcher with expertise in cancer metabolism/immunology to investigate metabolic heterogeneity as a driver of cancer metastasis. @CBM_CSIC_UAM @criscancer #cancermetabolism #immunometabolism
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Nature research paper: Nerve-to-cancer transfer of mitochondria during cancer metastasis
go.nature.com/3HYTQie
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My two NIH cancer research grants were terminated today. One involving breast cancer prevention is an “outstanding investigator award” and had received a perfect score by reviewers. How does ending lifesaving cancer research make Americans healthier? @harvardmed @aacr
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Macrophage degradation of bacteria provides carbon atoms and amino acids that are recycled into various metabolic pathways. Very cool finding nature.com/articles/s41586-0…
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We are thrilled to announce the appointment of Alec C. Kimmelman, MD, PhD, as the next Chief Executive Officer at @nyulangone and Dean of @nyugrossman effective September 1, 2025.
Learn more: nyulangone.org/news/nyu-lang…
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Hi #metabolism #pancreaticcancer #lipidtime twitter! Excited to share
@PatrickJonker4
work on how the microenvironment limits the metabolic capacity of pancreatic cancers (PDAC), which sensitizes these tumors to dietary interventions. 1/17
Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis biorxiv.org/content/10.1101/… #biorxiv_cancer
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Thrilled to share our new study on CAFs and NK cells, now online 🌟 in CD!!
NK cells are ideal candidates for cancer killing since they don't need antigen specificity. But they are usually not active in tumors. We wondered whether this could be due to inhibition by CAFs 🧵👇
Now online in @CD_AACR: Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anti-Cancer Cytotoxicity in Breast Cancer - by @AviadBenShmuel, @YaelGruper, @CoralHalperin, @shouval and colleagues doi.org/10.1158/2159-8290.CD… @WeizmannScience
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