#PancreaticCancer Research Lab interested in selective #autophagy, iron, therapeutic resistance, and #proteomics. @DanaFarber, @BrighamWomens, @harvardmed
Boston, MA
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The Mancias Lab @DanaFarber is fighting #PancreaticCancer on #WorldPancreaticCancerDay #WPCD2017 #WPCD #PANCaware #DemandBetter @PanCAN
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Preprint by @ManciasLab @DanaFarber_Hale
KRAS inhibition drives adaptive surfaceome remodeling and reveals ALPP/ALPPL2 as a targetable vulnerability in #PancreaticCancer
biorxiv.org/content/10.64898…
The surfaceome of KRASi resistant cells harbors many potential targets for ADCs, TCRs
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Amazing news today, culmination of years of research & clinical trials in #PancreaticCancer.
The @RevMedicines approval for Rasonque (Daraxonrasib) will open many doors, including other inhibitors in this space & combinations. @OncoAlert @KRASKickers
fda.gov/news-events/press-an…
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Excited to share our latest story @NatureComms. Here, we used quantitative proteomics, metabolomics and in vitro/in vivo CRISPR screens to define mechanisms of resistance to DHODHi in PDAC and propose combinatorial approaches with BCL-XL inhibitors:
nature.com/articles/s41467-0…
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How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer?
A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀
sciencedirect.com/science/ar…
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During the keynote addresses at #AACRpan24, Eileen M. O’Reilly and Joseph D. Mancias discussed how understanding pancreatic cancer’s strengths can help researchers uncover its weaknesses. Learn more on the #AACRBlog: bit.ly/47G1kQ9 @EileenMOReilly @ManciasLab
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Joseph D. Mancias discussed "Targeting Autophagy in Pancreatic Cancer" in a Rising Star Keynote Lecture during the AACR Special Conference on Advances in Pancreatic Cancer Research.
#AACRpan24 @ManciasLab
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The (almost) full program is now online with an amazing lineup of speakers!
#AACRPan24
@EileenMOReilly @ManciasLab @DrJashDatta @TeresaZimmers @DrHendifar @JanowitzTobias @wantong_yao @MaraShermanLab @KenOliveLab @andrewaguirremd @cjder23 @bryant_kl @pratt_ed @mggoggins @ChristieTowers @Cosimo_Commisso @Chiolaboratory @nada_kalaany and those not on Twitter. See you all in Boston!
aacr.org/meeting/aacr-specia…
@AACR #PancreaticCancer
Abstract submissions are now open for the @AACR special conference on #PancreaticCancer #AACRPan24
Outline of proposed program below:
aacr.org/meeting/aacr-specia…
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WE ARE HIRING! We are looking for a motivated postdoc to work on a fully-funded project studying the role of iron metabolism in drug resistance in pancreatic cancer. 3 weeks left to apply. Please spread the word.
au.dk/om/stillinger/job/post…
lnkd.in/eNgDM74z
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Our #OpenAccess review on #PancreaticCancer - advances & challenges is now online at @CellCellPress
Many thanks to @CJHPhD @Pasca_Lab & @LyssiotisLab for all the hard work & @jiaying_tan6 for the opportunity.
It’s FREE to read so share widely!
cell.com/cell/fulltext/S0092…
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We are so inspired by patients like Candace and her experience. With a loving and supportive family and the latest treatments at @DanaFarber, Candace is a source of hope for more patients with pancreatic cancer. blog.dana-farber.org/insight…
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Researchers at @DanaFarber and other institutions recently made important discoveries into the recycling system of pancreatic cancer cells, a promising step toward targeted therapies for one of the most challenging cancers. blog.dana-farber.org/insight…
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Pancreatic cancer cells operate a recycling program that would be the envy of any municipality — but the only beneficiaries are the cells themselves. blog.dana-farber.org/insight…
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A cross-country collaboration between former Damon Runyon-Rachleff Innovators @rushika_perera and @ManciasLab uncovered another way that #PancreaticCancer evades targeted therapies – and a new potential therapeutic target: bit.ly/3uQwFgd
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Latest Wolpin-Nowak lab paper on single cell, in situ protein-based characterization of transcriptional subtypes in pancreatic cancer now out in @CR_AACR aacrjournals.org/cancerres/a…
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Now online in @CD_AACR: Targeting UGCG Overcomes Resistance to Lysosomal #Autophagy Inhibition by Vaibhav Jain, David Speicher, @AmaravadiRavi and colleagues @TheWistar @PennCancer aacrjournals.org/cancerdisco…
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Robert Hale's determination in @DanaFarber and the Hale Family's incredible generosity help drive @DanaFarber_Hale closer to a cure for pancreatic cancer.
forbes.com/video/63128816421…
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On the cover!! Thanks @CD_AACR for featuring work from our lab by Miru Ravichandran and @ManciasLab @SantanaCodina on the cover !
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Thanks to @CD_AACR for featuring our stories @ManciasLab and @rushika_perera on the cover of the September issue!
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🚨Job Posting: The @YatrikShahLab & @LyssiotisLab are looking for a postdoc to study the role of iron, O2, & metabolism in erythropoiesis. Opportunities to learn and employ multiple cutting-edge technologies in 2 ~pretty cool labs 😁 DM with interest.
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