Congratulations to @SantanaCodina on your amazing time in the Mancias Lab! We are so lucky to have worked with you over the years on #PancreaticCancer biology and are pumped to see what your #NewPI adventure holds in store! Buen viaje and good luck Naiara!!
The Mancias Lab and @GygiLab are hiring a co-mentored postdoctoral fellow. Join our teams to work on projects related to #PancreaticCancer and #Proteomics. Check out the post below and DM or e-mail me if interested. Please RT! @DanaFarber_Hale @HarvardCellBio
Good news in these strange days!! Our paper is out @CellReports !! We have used quantitative temporal proteomics to define mechanisms of adaptation to KRASG12C inhibitors and to develop combinatorial regimens. Congrats @amrita_singh89@ManciasLab!
cell.com/cell-reports/fullte…
to enhance response to KRASG12C monotherapy. Combinations with CDK4/6i and HSP90i showed promise but would require further extensive pre-clinical testing to validate. All of our quantitative temporal proteomic data is available via an interactive website: manciaslab.shinyapps.io/KRAS….
KRASG12C inhibitors are now in clinical trials for oncogenic KRASG12C-driven tumors including in #LungCancer and patients are showing responses. As one concern based on experience with other targeted therapies is development of resistance, we modeled adaptation/resistance
Naiara Santana-Codina presents work from the lab at #AACRPanCA19 on using quantitative temporal proteomics to identify combinatorial treatment strategies in #PancreaticCancer, great work Naiara @SantanaCodina! @HaleCenter_DFCI
Awesome #EMBLBioIron conference this last week with great presentations/posters including on role of iron metabolism in cancer and ferroptosis. Great catching up with collaborators including @YatrikShahLab @suzcloo