Cutting-edge research, news, commentary, and visuals from the Science family of journals. Follow @NewsfromScience for stories from our News team.

Washington, DC & Cambridge, UK
14 years ago, the revolutionary genetic tool CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a Nobel Prize for in 2020.⁠ ⁠ Bacteria and archaea protect themselves from invasive foreign nucleic acids through an RNA-mediated adaptive immune system called CRISPR (clustered regularly interspaced short palindromic repeats)/CRISPR-associated (Cas). ⁠ ⁠ In the 2012 paper, researchers found that for the type II CRISPR/Cas system, the CRISPR RNA (crRNA) as well as the trans-activating crRNA—which is known to be involved in the pre-crRNA processing—were both required to direct the Cas9 endonuclease to cleave the invading target DNA. Furthermore, engineered RNA molecules were able to program the Cas9 endonuclease to cleave specific DNA sequences to generate double-stranded DNA breaks.⁠ ⁠ On #WorldCRISPRDay, read the landmark paper that describes the discovery: scim.ag/4nPmoe8
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New archaeological discoveries at Shég’ Xdaltth’í’, a 13,800-year-old base camp site in interior Alaska, may provide evidence for a trans-Beringian cultural link with other sites to the west. Learn more in @ScienceAdvances: scim.ag/4yj2hcA
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AI-designed proteins can now expand the CRISPR toolbox beyond what evolution has produced. In a recent Science study, researchers report the design of synthetic RNA-guided nucleases that match or exceed the activity of natural enzymes, revealing how structure-guided design can generate functional genome-editing proteins with substantially different sequences. Learn more on #WorldCRISPRDay: scim.ag/4yXBW5c
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STAT3 is a cytokine-sensitive switch regulating NK cell differentiation in a mouse model of antiviral response. Learn more in @SciImmunology about the study’s possible implications for STAT3 immunotherapy and cancer progression: scim.ag/3WsoUhy
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Science is publishing an Erratum for the June 2026 Research Article “Divergent evolution of nitrogen cycling along gradients of landscape water velocities.” scim.ag/4jm6vN3
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Join #ScienceWebinars for their next #Technology broadcast on Wednesday, 21 October at 12 p.m. ET ➡️ Battle for the gut: From microbial competition to therapeutic communities. Register now: bit.ly/482ybzm
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In Science, researchers present RFdiffusion3, a new generative AI system that designs proteins and nucleic acids atom by atom, which could enable the ability to engineer novel biomolecules with precise, complex functions. Learn more: scim.ag/4hOQVIF
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Honey bees inject venom with a two-stroke stinger. Learn more: scim.ag/4yXrVF5 @NewsfromScience
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By parsing metabolic data from more than 18,000 participants in China, scientists have derived new “clock” models of metabolic #aging that incorporate novel metrics linked to higher chronic disease risk and all-cause mortality. @ScienceTM scim.ag/4ynTiXI
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"Governments across the world are treating data as a strategic asset. But data alone are not enough. Infrastructure must be developed that can provide signals about which data are 'fit for purpose' for the increasingly vast number of potential uses," write Julia Lane and Natasha Noy in a new #ScienceEditorial. scim.ag/4hSEydb
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In the latest #SciencePodcast🎙️, Contributing Correspondent Lizzie Wade dives into how archaeologists are revisiting the standard Inca chronology as radiocarbon dates mix up the timeline for the empire’s inception and growth. 🎧 Listen here: scim.ag/4jmkwKA
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Applying Fc engineering, researchers fashion potent bispecific antibodies against #SARSCoV2 that can be delivered via mRNA to target multiple viral epitopes and can constrain the virus’ ability to evade recognition. @ScienceTM scim.ag/4jpH795
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"I’m still not the person who has the loudest voice, or who speaks first or most frequently in a meeting. I still feel the urge to wait for perfect words. But I have become more willing to offer my voice." #ScienceWorkingLife scim.ag/4dGTutR
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Science is publishing an Erratum for the July 2026 Research Article “Enabling sustainable supply of the essential cancer medicines etoposide and teniposide in yeast.” scim.ag/4hLkSJy
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A Moscow court sentenced Russian ornithologist Sofya Rozenfeld to 3.5 years in a penal colony on 7 October over two small donations to an anticorruption organization proscribed by the Russian government. scim.ag/4s2ZMcU @NewsfromScience
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How does Jonathan, the world’s oldest terrestrial animal at 194 years young, defy aging? Researchers in @ScienceAdvances sequenced the Aldabra giant tortoise’s genome to discover possible molecular factors related to his remarkable longevity. scim.ag/4ydQXib
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A 1960 prediction, published in Science, that global population growth would culminate in a mathematical singularity on 13 November 2026 is proving inaccurate. In this #ScienceBooks Essay, Jaiver Birchenall uses this failed prediction to highlight the risks of treating historically contingent trends as enduring laws in forecast modeling. scim.ag/4ebjFZH
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Women are more likely than men to develop dementia, and not just because they tend to live longer. One reason may be menopause, the time in midlife when sex hormones drop and menstruation stops—and which some researchers are coming to see as a stress test for the brain. Learn more: scim.ag/47atALj @NewsfromScience
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Tinnitus—a constant ringing or buzzing in the ears that affects about 15% of people—is difficult to understand and even harder to treat. In 2020, scientists found that shocking the tongue—combined with a carefully designed sound program—can reduce symptoms of the disorder, not just while patients are being treated, but up to 1 year later. Learn more: scim.ag/474VmsH #ScienceMagArchives
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Join #ScienceWebinars for their next #Technology broadcast on Wednesday, 21 October at 12 p.m. ET ➡️ Battle for the gut: From microbial competition to therapeutic communities. Register now: bit.ly/482ybzm
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Borrowing an idea from one research discipline to solve a thorny problem in another is an age-old scientific trick. Charles Darwin’s theory of natural selection, for example, famously inspired algorithms in computer science that “evolve” solutions to complex problems. But such clever leaps are fleetingly rare. For #AI, however, hopping between fields can be a breeze. Researchers highlighted that ability with the release of 36 preprints produced with a single suite of AI tools called BootLoops. The so-called harness can be used with any large language model, such as Anthropic’s Claude or OpenAI’s ChatGPT. And in just 3 months, researchers used Claude outfitted with BootLoops to cross-pollinate at a massive scale, spotting—and precisely solving—problems in seemingly unrelated fields that share the same mathematical structures. The resulting papers range widely, from figuring out the age of sunspots, to analyzing government health policies, to attempting to decipher a mysterious medieval manuscript. Learn more: scim.ag/3TUUyDJ
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Researchers in @ScienceAdvances have demonstrated that brief physical contact between healthy and bleached coral can restore algae to the bleached coral, leading to their full recovery. scim.ag/4s40Tt3
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Tall ice cliffs can calve faster than previously thought, but new observations suggest they are unlikely to trigger the runaway retreat feared in some projections of Antarctic ice loss. Learn more in Science: scim.ag/4yjj5R3
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In @SciSignal, scientists show that intracellular changes to receptor conformation alter how activating molecules bind to a biologically important GPCR from outside the cell through an “inside out” mechanism. scim.ag/4ynGkcI
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In a new #ScienceEditorsBlog, Editor-in-Chief Holden Thorp talks to reporter Jeff Horwitz, who shared the 2026 Pulitzer Prize with Engen Tham for their coverage of Meta, which exposed information that was held internally at the company on how Facebook and Instagram were causing harm. This reporting also served as inspiration for the movie "The Social Reckoning." ⁠ ⁠ Thorp and Horwitz discuss the Science papers at the center of the story, which raised questions about the extent to which Facebook was knowingly stoking political polarization, as well as the challenges of conducting research about the impact of social networking platforms.⁠ ⁠ Learn more: scim.ag/4inBrve
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In a new #SciencePerspective, researchers discuss how climate change could shape future human risks of mercury exposure. scim.ag/4AWQWSb
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Increased visits by loved ones to people in California prisons—thanks to cheaper gas prices—decreased misconduct incidents, according to a new @ScienceAdvances analysis. scim.ag/4AUcrTz
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In a new #SciencePolicyArticle, researchers report on a large-scale randomized controlled trial evaluating the impacts of classroom phone restrictions on student outcomes in India. The findings show that restricting phone use can support learning, particularly among lower-performing students. Learn more: scim.ag/4yahHQA
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A new Science #Immunology study identifies a #DendriticCell population that expresses the RORC gene in malignant ascites from #gastroesophageal cancer patients, which may play a role in antitumor immunity. scim.ag/3VFalXI
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A new AI framework called AlphaProof Nexus can autonomously tackle select math problems, seeking proofs and using verification to ensure the resulting solutions are logically sound, researchers report in Science. 📄: scim.ag/4y7Rlyx #SciencePerspective: scim.ag/4s0Kqpx
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In Science, researchers present RFdiffusion3, a new generative AI system that designs proteins and nucleic acids atom by atom, which could enable the ability to engineer novel biomolecules with precise, complex functions. Learn more: scim.ag/4hOQVIF
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The traditional Inca chronology has collapsed. New radiocarbon dates show the empire lasted longer than was previously thought—and met more resistance. Learn more this week in Science: scim.ag/4yOd9Ah
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Honey bees inject venom with a two-stroke stinger. Learn more: scim.ag/4yXrVF5 @NewsfromScience
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In the 1950s, scientists tried to define "normal" humans. The problem? They couldn't find any. The Normals, a #SciencePodcast🎙️ series that explores this story, is a finalist for The @signalawards! Today is the last day to support us for the listener’s choice award. Cast your vote here: scim.ag/4sqlTdT
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By parsing metabolic data from more than 18,000 participants in China, scientists have derived new “clock” models of metabolic #aging that incorporate novel metrics linked to higher chronic disease risk and all-cause mortality. @ScienceTM scim.ag/4ynTiXI
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"Governments across the world are treating data as a strategic asset. But data alone are not enough. Infrastructure must be developed that can provide signals about which data are 'fit for purpose' for the increasingly vast number of potential uses," write Julia Lane and Natasha Noy in a new #ScienceEditorial. scim.ag/4hSEydb
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In the latest #SciencePodcast🎙️, researcher Javier Birchenall discusses predictions of world-ending crises—starting with a prediction published in a Science paper in 1960 that suggested Earth’s population would reach a singularity on 13 November 2026. 🎧 Listen here: scim.ag/4rYY6kS
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An artificial lymph node provides a protected haven for tolerogenic dendritic cell therapy for autoimmune encephalitis in mice, with possible implications for #MultipleSclerosis therapy. @ScienceTM scim.ag/3Ue08Ba
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"I have come to realize teaching, mentoring, and academic life are part of who I am. No matter where my career or destiny takes me, I do not think I can completely walk away from them." #ScienceWorkingLife scim.ag/3TU7dqe
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New in Science #Robotics: Robot demonstration videos pose issues of reproducibility and legal liability for the community if they imply more autonomy than the facts support. scim.ag/4AZh52H
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A Moscow court sentenced Russian ornithologist Sofya Rozenfeld to 3.5 years in a penal colony on 7 October over two small donations to an anticorruption organization proscribed by the Russian government. scim.ag/4s2ZMcU @NewsfromScience
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Buried in a museum drawer for nearly 50 years, a fist-size fossil has handed paleontologists the evidence they’d been hunting for: unmistakable claws on one of the oldest known relatives of spiders and scorpions. Learn more on #NationalFossilDay: scim.ag/4e8Cq0d
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How does Jonathan, the world’s oldest terrestrial animal at 194 years young, defy aging? Researchers in @ScienceAdvances sequenced the Aldabra giant tortoise’s genome to discover possible molecular factors related to his remarkable longevity. scim.ag/4ydQXib
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A 1960 prediction, published in Science, that global population growth would culminate in a mathematical singularity on 13 November 2026 is proving inaccurate. In this #ScienceBooks Essay, Jaiver Birchenall uses this failed prediction to highlight the risks of treating historically contingent trends as enduring laws in forecast modeling. scim.ag/4ebjFZH
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A Spinosaurus species uncovered in northern Niger appears to have been a wading predator of fish like its close relatives, but it lived as many as 1000 kilometers inland from the Tethys Sea. The fossil find may represent a third phase of evolution for this group of massive, fish-eating dinosaurs. Learn more on #NationalFossilDay: scim.ag/4tOnxpY
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Women are more likely than men to develop dementia, and not just because they tend to live longer. One reason may be menopause, the time in midlife when sex hormones drop and menstruation stops—and which some researchers are coming to see as a stress test for the brain. Learn more: scim.ag/47atALj @NewsfromScience
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Wooden artifacts and imprints show a substantial role for Neanderthal woodworking in the Middle Paleolithic. Learn more in @ScienceAdvances: scim.ag/476NcQA
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Why do large dogs tend to live shorter lives than their smaller counterparts? The answer may be written into their epigenome, according to a new study in Science. The findings reveal that larger and male dogs undergo accelerated molecular aging, with pronounced DNA methylation on the X chromosome and at transposable elements. Learn more: scim.ag/3VZtl3f
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Scientists show that a protein named RGS4 plays a central role in chronic neuropathic pain by maintaining hypersensitivity after nerve damage—a finding that could lay the road for precision drugs that target this protein. @SciSignal scim.ag/47DLyG8
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In a new #SciencePerspective, researchers discuss how climate change could shape future human risks of mercury exposure. scim.ag/4AWQWSb
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Increased visits by loved ones to people in California prisons—thanks to cheaper gas prices—decreased misconduct incidents, according to a new @ScienceAdvances analysis. scim.ag/4AUcrTz
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In a new #SciencePolicyArticle, researchers report on a large-scale randomized controlled trial evaluating the impacts of classroom phone restrictions on student outcomes in India. The findings show that restricting phone use can support learning, particularly among lower-performing students. Learn more: scim.ag/4yahHQA
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A new Science #Immunology study identifies a #DendriticCell population that expresses the RORC gene in malignant ascites from #gastroesophageal cancer patients, which may play a role in antitumor immunity. scim.ag/3VFalXI
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