Tony K.T. Lam@TonyKTLam

Professor of Physiology & Medicine studying diabetes & obesity at the Toronto General Hospital Research Institute & U of T

 Toronto
physiology.utoronto.ca/facul…
Joined November 2017
85 Photos and videos
New content online: Lipid sensing and brain hormone receptors in food intake and glucose regulation dlvr.it/TTXB6R
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Thanks to everyone who joined us for today's seminar with Alison Xu! These sessions bring in experts from across Canada and around the world to share their latest research with our BBDC members, and we're looking forward to even more excellent speakers in 2026.
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Congrats to 1st-author Nick Garrido, MD/PhD candidate @uoftmedicine @UHN_Research @UHN @BBDC_UofT !
Diabetes, an ADA research journal 🧪@Diabetes_ADA
11 Sep 2025
Lipids Engage a Kidney-Brain GDF15 Axis to Suppress Food Intake Read here➡️ doi.org/10.2337/db25-0174 @ADA_Pubs
Graphical abstract showing the USI infusion of lipids

ALT Graphical abstract showing the USI infusion of lipids

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diabetesjournals.org/diabete…

Lipids Engage a Kidney-Brain GDF15 Axis to Suppress Food Intake

Growth differentiation factor 15 (GDF15) is an anorectic and weight loss–inducing hormone that responds to stimuli such as endoplasmic reticulum stress, ex

diabetesjournals.org
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Thank you Miguel and Ruben! The Satiety Awakens: Metformin Restores Intestinal Lipid Sensing diabetesjournals.org/diabete…
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nature.com/articles/s41574-0… Obesity and the kidney: mechanistic links and therapeutic advances @SociedadSeedo @SENefrologia @jorgericof @jlgorriz @PepaSolerR
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Lipids Engage a Kidney-Brain GDF15 Axis to Suppress Food Intake Read here➡️ doi.org/10.2337/db25-0174 @ADA_Pubs
Graphical abstract showing the USI infusion of lipids

ALT Graphical abstract showing the USI infusion of lipids
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Here Tony Lam and colleagues @UHN identify that lipid sensing in HFD-fed rats is enhanced by metformin to trigger an endocrine GIP to NTS GIPR axis to reduce food intake unveiling potential targets to enhance GIP action and reduce weight in #obesity diabetesjournals.org/diabete…

Metformin Boosts Intestinal Lipid Sensing via GIP to Suppress Feeding

An acute increase of lipids in the upper small intestine (USI) of rodents and humans triggers lipid-sensing pathways to reduce food intake. However, USI li

diabetesjournals.org
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Congrats Kyla Bruce & Song-Yang Zhang @mcgillu and Thank you Allison Xu & Tomas Bachor @UCSF! @UHN @TGHRI_UHN @BBDC_UofT nature.com/articles/s41467-0…

Pharmacological and physiological activation of TGR5 in the NTS lowers food intake by enhancing...

Nature Communications - The role of bile acid receptor TGR5 in feeding regulation remains elusive. Here, authors show that physiological and pharmacological activation of TGR5 in the nucleus of the...

nature.com
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Our next annual meeting is once again a satellite of @CAN_ACN 🙏 We are thrilled to welcome Zachary Knight @zaknight as our Keynote lecturer and Melissa Chee @thecheelab and Tony Lam @TonyKTLam as Plenary speakers 🤩 Submit your abstracts trainees - it's free!!
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Thanks to everyone who joined us for our Trainee Lab Seminar Series today, featuring presentations from Song-Yang Zhang, Cori Lau and Gabrielle Viscardi.
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Tony K.T. Lam retweeted
Cell@CellCellPress
30 Jul 2024
In the latest issue! A metabolic balance of GLP-1 and NMDA receptors in the brain dlvr.it/TBFznQ
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Tony K.T. Lam retweeted
Cell@CellCellPress
25 Jul 2024
Now live! Explore our newest anniversary focus issue on Metabolism! In this issue, you'll find reviews and perspectives on diabetes, obesity, the microbiome, and more: cell.com/cell/issue?pii=S009… #50YearsofCell Cover art by @qwertess
Cover of the issue, which reflects the Leading Edge articles we present on cardiometabolic health, metabolic heterogeneity, cancer metabolism, nutrition and dietary interventions, diabetes, and obesity. Artwork credit: Sonhita Chakraborty.

ALT Cover of the issue, which reflects the Leading Edge articles we present on cardiometabolic health, metabolic heterogeneity, cancer metabolism, nutrition and dietary interventions, diabetes, and obesity. Artwork credit: Sonhita Chakraborty.

First page of the editorial, which can be found at https://www.cell.com/cell/fulltext/S0092-8674(24)00714-1

ALT First page of the editorial, which can be found at https://www.cell.com/cell/fulltext/S0092-8674(24)00714-1

First page of the issue's table of contents

ALT First page of the issue's table of contents
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Had a fantastic time @BBDC_UofT. Great day seeing the fantastic work happening in Toronto.
Banting & Best Diabetes Centre@BBDC_UofT
10 May 2024
Our Charles Hollenberg Memorial Lectureship awardee is the compelling and informative @seeleyrj.
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Thanks to everyone who joined us today for a fantastic day of learning and networking.
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Thanks to Dr. Seung Kim for his informative presentation today as part of our Speaker Series. Thanks also to all those who attended this session.
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Friday, May 10th is our 33rd Annual Scientific Day. We hope to see all of our BBDC members at this event! eventbrite.ca/e/bbdc-33rd-an…
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We are delighted that Ashley Castellanos-Jankiewicz, Senior Editor of Nature Metabolism, will give a special seminar on navigating the publishing process at the journal. Join us in-person on May 9 from 4 – 5 p.m. If you’d like to attend, please RSVP the BBDC admin by May 2nd.
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The last BBDC seminar series for this academic year will feature Dr. Seung K. Kim from @StanfordMed. Join us Tuesday, April 16 from 10 – 11 a.m. In person only. bbdc.org/events/bbdc-seminar…
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Reminder - The last BBDC Trainee Lab Seminar Series for this academic year will take place on  Friday, April 12, 2024  from 12-1 pm. The seminar will be held in-person only. bbdc.org/events/bbdc-trainee…
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