Tyler Alban@TylerAlban1

PhD in Molecular Medicine. Currently working on immunotherapies in cancer at the Lerner Research Institute

 Cleveland, OH
Joined September 2017
73 Photos and videos
medicalxpress.com/news/2026-…

A quantum machine learning framework to predict neoantigen immune response

Cleveland Clinic and IBM researchers are using quantum computing to tackle one of the most challenging problems in immuno-oncology: predicting which tumor mutations will trigger an immune response.

medicalxpress.com
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Excited to share our second paper on #quantum machine learning out now in Science Advances! 🎉 Here we developed a model to predict neoantigen immunogenicity using a quantum convolutional neural network. #AI #immunology #immunology #quantum science.org/doi/10.1126/scia…

Quantum convolutional HLA immunogenic peptide prediction (Q-CHIPP): Next-generation neoantigen...

Quantum convolutional neural networks predict immunogenic neoantigens using small training data.

science.org
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Tyler Alban retweeted
Filippo Utro@FilippoUtro
Jul 24
📢 🎉 Excited to share our new @ScienceAdvances paper on quantum computing for HLA immunogenic peptide prediction and neoantigen discovery. ⚛️🧬 A great collaboration at the intersection of #QuantumComputing, #AI, and #CancerResearch. 📄 Paper: science.org/doi/10.1126/scia…

Quantum convolutional HLA immunogenic peptide prediction (Q-CHIPP): Next-generation neoantigen...

Quantum convolutional neural networks predict immunogenic neoantigens using small training data.

science.org
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Tyler Alban retweeted
Tyler Alban@TylerAlban1
May 26
Excited to share our new preprint with @ClevelandClinic + @IBMResearch  We used AI + physics-based design to engineer TCRs targeting cancer neoantigens with:
✔ Mutant specificity
✔ Functional activation 🔗 biorxiv.org/content/10.64898…
#Immunotherapy #Cancer
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Tyler Alban retweeted
Nadeem Riaz
@xrtGenomics
Jan 5
🥳🎆 Kicking of 2026 with our work showing intra-tumoral bacteria 🦠 affect outcomes of Radiotherapy + anti-PD-L1 now out in @NatureCancer with sister paper by @nataliesilvermd! Even when trials "fail" – we can learn from them! nature.com/articles/s43018-0…. -- w/ @GeneCollector, @imrtlee, @TylerAlban1, @DrHaddadRobert, the Pfizer team and more! (1/N)

Tumor ecosystem and microbiome features associated with efficacy and resistance to avelumab plus...

Nature Cancer - Chan and colleagues report that tumor ecosystem and microbiome features are associated with response to anti-PD-L1 avelumab plus chemoradiotherapy in patients with locally advanced...

nature.com
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Tyler Alban retweeted
Anirban Maitra@Aiims1742
Jan 2
Two papers in @NatureCancer highlighting the role of intratumoral bacteria & associated immune architecture (e.g., neutrophil influx) in mediating resistance to immunotherapy in head & neck cancer. nature.com/articles/s43018-0… nature.com/articles/s43018-0… @GeneCollector @xrtGenomics
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Tyler Alban retweeted
Waggoner Lab@LabWaggoner
Jan 2
Tumor bacterial burden dictates immunotherapy fate in head & neck cancer (Preview @dspakowicz) nature.com/articles/s43018-0… @NatureCancer @GeneCollector @ClevelandClinic @imrtlee @MSKCancerCenter @xrtGenomics @pfizer @TylerAlban1 @DrHaddadRobert @DanaFarber nature.com/articles/s43018-0…
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Excited to highlight our recent work in bladder cancer using single cell RNAseq to identify a novel subset of CD6 positive T-cells that associate with BCG resistance. Great collaboration with Angela Ting and Byron Lee! nature.com/articles/s41698-0…
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It was a pleasure to present our teams work on AI designed T cell receptors at #ACS2025 ! Really exciting work coming out of the @ClevelandClinic @IBMResearch #discoveryaccelerator and the @GeneCollector lab!
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Check out our new preprint! Here we optimized a #quantum #neuralnetwork for neoantigen prediction and demonstrated advancement in immunogenicity prediction and patient stratification based on predicted neoantigen load. biorxiv.org/content/10.1101/…

Quantum Convolutional HLA Immunogenic Peptide Prediction (Q-CHIPP): Next-Generation Neoantigen...

The immune system is an intricately evolved series of cellular and protein-protein interactions, which defend the body against pathogens and abnormal cells such as cancer. A key player in the...

biorxiv.org
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Great to have @jmetzcar visit us yesterday and share insights into how mathematical modeling can inform #GBM growth! Looking forward to continuing these exciting collaborations!
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Excited to share our manuscript on quantum machine learning! I’m a believer in team science so here we teamed up with quantum computing experts from @IBMResearch and used quantum ensemble approaches for modeling transcriptomic data to predict IO response. arxiv.org/abs/2506.02213
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Incredible opportunity to share the stage tonight with @VamsiVelcheti tonight at an amazing venue #ASCO2025 @CLEImmunoUpdate
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Here at #ASCO2025 excited to give a talk later on our AI work! @CLEImmunoUpdate
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Tyler Alban retweeted
Timothy Chan@GeneCollector
19 Oct 2024
At the National Academy of Medicine — Joined by my dear buddies and comrades in arms against cancer! Congrats!! @wolchokj @JenWargoMD Luis Diaz
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Super cool to see our work highlighted by @ACIR_org If you haven’t had a chance to check it out yet this is a great summary!
ACIR
@ACIR_org
16 Oct 2024
New insights into nivolumab-induced immunoediting bit.ly/403lMIZ  @TylerAlban1  @xrtGenomics  @GeneCollector
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Tyler Alban retweeted
ACIR
@ACIR_org
16 Oct 2024
New insights into nivolumab-induced immunoediting bit.ly/403lMIZ  @TylerAlban1  @xrtGenomics  @GeneCollector
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We get all the cool tech in @GeneCollector lab! Excited to see how label free live cell sorting helps improve our single cell seq data quality! 🧐 @levitasbio
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Tyler Alban retweeted
Ben Creelan, MD MS
@BenCreelan
3 Oct 2024
Excited to be part of team science published today in @NatureMedicine with @TylerAlban1 🗞️ Both NSCLC responders and non-responders had anti-tumor T cells. Responders target clonal antigens. 👉rdcu.be/dVyiU
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