Andrew Grant retweeted
Version v0.10.0 of the MendelianRandomization package is currently making its way to CRAN. Two major new functions: mr_clr implements weak instrument robust methods outlined in onlinelibrary.wiley.com/doi/… (Anderson–Rubin, Kleibergen, and the conditional likelihood ratio test), ...
1
15
50
4,161
New paper “A Bayesian approach to Mendelian randomization using summary statistics in the univariable and multivariable settings with correlated pleiotropy” now out in The American Journal of Human Genetics @AJHGNews: authors.elsevier.com/a/1iN9V…. Many thanks to @stevesphd!
1
4
22
3,811
We propose an approach for MR using GWAS summary statistics which can account for correlated pleiotropy (i.e., violations of the InSIDE assumption) and weak instruments. We also extend the method to the multivariable MR setting.
1
238
We name the methods MR-Horse and MVMR-Horse after the horseshoe shrinkage prior used to model pleiotropic effects.
R code for implementing the methods can be found here👇
github.com/aj-grant/mrhorse
1
170
Andrew Grant retweeted
Congrats to our PhD student Ellen Dobrijevic on this brilliant primer on #mendelianrandomization. MR is a powerful method for dealing w/confounding to make causal inferences but needs careful consideration for robust results. Step by step guide to MR 🧭: doi.org/10.1016/j.kint.2023.…
Mendelian randomization for #nephrologists
doi.org/10.1016/j.kint.2023.…
@Sydney_Uni @ColumbiaKidney @ColumbiaPS @westmeadkids #ckd #MendelianRandomization
#KIXYZofStatistics
2
3
7
1,771
Andrew Grant retweeted
Our new review "Using genetic association data to guide drug discovery and development: Review of methods and applications" is now online at @ajhg: authors.elsevier.com/a/1gX1f…. Summarizes a lot of recent work from our group and others. Thread follows:
1
27
70
9,432
Andrew Grant retweeted
Just over two weeks to apply! A great opportunity to be exposed to the day-to-day activities of researchers in statistical methodology and statistics applied to biomedical problems. Please RT.
We are excited to launch our Summer Internship Programme.
Opportunity to experience life at the BSU, contribute to our established research portfolio and find about career opportunities.
More info & apply 👇
jobs.cam.ac.uk/job/34171/
#STEM #Careers #DataScience @Cambridge_Uni
5
4
Andrew Grant retweeted
Grant et al present a new statistical method:
for clustering variants based on their proportional associations w/ chosen traits
The result is more reflective of the underlying mechanisms the variants relate to
@andy_grant1 @dpsg108 @pauldwkirk @stevesphd
doi.org/10.1371/journal.pgen…
6
14
Andrew Grant retweeted
New preprint: "Bias in multivariable Mendelian randomization studies due to measurement error on exposures" led by a previous summer intern student Jiazheng Zhu and post-doc @andy_grant1 - arxiv.org/abs/2203.08668. Some thoughts follow!
1
5
27
Our paper introducing a new method for clustering genetic variants using genetic association data is now out. Many thanks to @dpsg108, @pauldwkirk and @stevesphd!
journals.plos.org/plosgeneti…
1
5
12
An excellent Tweetorial can be found here👇
New preprint online: "Noise-augmented directional clustering of genetic association data identifies distinct mechanisms underlying obesity" biorxiv.org/content/10.1101/…. We introduce a method for clustering genetic variants based on their associations with a set of traits. Tweetorial:
1
And an R package to implement the method can be found here👇
github.com/aj-grant/navmix
1
A recently published commentary in @BritJClinPharm on how statistical methods using genetic data can aid in drug development. bpspubs.onlinelibrary.wiley.…
1
3