Mother&Wife,GI Oncology,MGH, equity,global cancer care,social justice,liquid biopsies,drug discovery, women in medicine,discovering and being your best self
Boston, MA
- Tweets 1,925
- Following 1,684
- Followers 3,564
- Likes 10,786
A juxtaposition of grief and gratitude. 💔❤️ Ran the Chicago Marathon Sunday for Rachna, with her memory engraved on my medal. She lived with such light, vivacity, and tenacity, even facing her own mortality. Ran for you, Rach. We will carry your light always. 🙏🏽❤️ #TeamShroff
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get this done for our wonderful @rachnatshroff. I’ve known Rachna for a while, but witnessing her current journey has left me even more profoundly inspired. Nothing but absolute conviction to her work & cancer patients with the most graceful resilience.
Team we are SO CLOSE!!! Let’s get this done! @ConquerCancerFd @ASCO @VaniamGroup @DeannavanGestel @UAZCancer
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Terribly awkward speaking picture but incredibly wonderful day spent at Vandy! Great science and truly such a great group of colleagues and friends. Looking forward to all the great collaborations. Thanks again for inviting me
I would like to thank @aparna1024 @MassGenBrigham for serving as our inaugural @VUMCDiscoveries #strategicrelations visiting faculty to discuss a possible collaboration for our #ctDNA platforms in #colorectalcancer. Great talk! 👏 She’s a wonderful friend and colleague!
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Profoundly grateful for a beautiful friendship with the incomparable @rachnatshroff who continues to make a lasting impact on everyone she crosses paths with (and it’s alot of people!) thank you Don for this beautiful piece and sharing a piece of her with the broader community 💕
In a new NEJM Voices blog post, Don Dizon, MD, reflects on the profound shock of a colleague’s cancer diagnosis. Read “When Cancer Hits Home” and sign up for email alerts: nej.md/4i0fMK1
ALT A photo from the NEJM Voices blog post "When Cancer Hits Home" by Don Dizon, M.D. In the photo, Dr. Dizon and Dr. Rachna Shroff sit in front of a sign that reads, "The Women in Oncology Awards." Dr. Shroff is wearing a lei (the photo was taken in Hawaii).
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❤️ our GI onc family
🙏🏻🙏🏻 @aparna1024 for organizing this and highlighting our amazing #GI family with honorary member Dr. Nina Shah😁. Not everyone could make it…..These are some of the most INCREDIBLE people that you will meet and who share ONE mission: Omitting #cancer and helping others. #patientcare @KristenCiombor @rachnatshroff @ArdamanShergil1 @VanMorrisMD @adasarimd @smitha42 @DrCrystalD @DrKatePedersen @KlempnerSam and so many others! #friendships #workfamily #ASCO26
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Proud friend/mgbci colleague! @KlempnerSam one of a kind doctor, translational researcher and human. Helps that our senses of humor also align! Congratulations Sam on being the inaugural Tobins family chair in UGI cancer. Special evening honoring Sam and Mr.Tobins
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Few FIT tests given & 1 person set up with the @MassGenBrigham community health team to help navigate their colo. My 2/3 helpers giving out stars on passport cards for folks who stopped by the #crc table. Thanks @javawithJimmy @Jbetancourtpr @RickLee6 for another amazing year!
A great 5th Annual @javawithJimmy #YHJ @Jbetancourtpr Health Fair today! Inspiring words from our speakers and a beautiful day for our clinicians to meet people in the community where they are. Thanks to all for coming!
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One of my favorite events of the year! You’ll find me at the colorectal table (with kids in tow!)
We’re happy to partner with @javawithJimmy to bring health resources from the clinic to the community. Get your questions answered!
@BeverlyMoy @andrew02114 @MGHEquity @ChiFuJeffYang @elliefund @aparna1024 @AdjoaGIMD @TheSickleDoc @RAPCancer
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a hard loss to process. Asal was a remarkable person and the world needed Asal longer. Her advocacy for young adults facing colorectal cancer was as powerful as it was compassionate, driven by her own experience & unwavering determination to create change. Rest easy, friend.
Heartbroken by the loss of Asal Sayas, a champion in the fight against young adult cancer and HIV/AIDS. Asal was a treasured friend, organizer, and advocate. My heart is with her family and community as they suffer this tremendous loss. Asal will be missed.
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Aparna Raj Parikh retweeted
I always love a good chat with this crew 🤩🤓 Especially with some of the really interesting data out there these days.
@aparna1024 @MPishvaian @GIMedOnc @OncLive
Stay at the forefront of CRC care. Our new peer-exchange series explores the rapidly evolving landscape of unresectable and metastatic colorectal cancer, from emerging biomarkers and ctDNA to the latest therapeutic strategies.
Explore the program here: hubs.li/Q044gxLw0
@DrKatePedersen @MayoClinic @MPishvaian @HopkinsMedicine @GIMedOnc @aparna1024 @MassGenBrigham
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Aparna Raj Parikh retweeted
Happy to report the first clinical evidence revealing how tumors develop resistance to p53-Y220C reactivators out today @CD_AACR @MassGenBrigham @harvardmed #CorcoranLab #Rezatapopt #p53Y220C #PYNNACLE
aacrjournals.org/cancerdisco…
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Proud to be an investigator on this study! For many years now, I have taught our fellows that they can no longer just say KRAS mutant (need to specify variant). Now, this is the first for p53 Y220C today with more to come.
In a phase 1 study of the oral p53 reactivator rezatapopt in heavily pretreated patients with TP53 Y220C–mutated solid tumors, the most common adverse events were nausea and vomiting, and the overall response was 20%. Full PYNNACLE study results: nej.md/3OIQC5P
Science behind the Study: Restoring Function to a Variant of p53 in Solid Tumors nej.md/3N0pQW8
ALT Panel A: A figure showing the change in the sum of diameters of the target lesions across tumor types. Panel B: A figure showing the overall duration of treatment and the time to first response observed in 46 patients treated with a dose in the observed efficacious-dose range who had wild-type KRAS.
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Aparna Raj Parikh retweeted
Great news! #pressrelease #BRAFV600E mutant #tumor metastatic #colorectal #cancer COHORT 3 FOLFIRI arm has met endpoints for PFS vs. FOLFIRI + bev. 🙏to all patients that participated! #drugdiscovery @PfizerOncMed
pfizer.com/news/press-releas… #cancerresearch
@VUMCDiscoveries @OncoAlert
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Aparna Raj Parikh retweeted
The brilliant #StandUpToCancer scientists are on the front lines in the fight against cancer. Join them now through #ValentinesDay by posting a kissing photo with #KissCancerGoodbye and tagging @SU2C! 💋
You can also support their groundbreaking cancer research with a donation at StandUpToCancer.org/KissCanc…. ❤️
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Thanks @CheSturridge and for beautiful 🏃🏽♀️ rec!
The “A”in CTDNA is for @aparna1024 delivering a very informative Keynote Address on “ The Liquid Biopsy Revolution “ (always a HOT Topic) during the Inaugural @MoffittNews GI Cancer Symposium .
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Less novel from when we first set out to do this, but we thought it was important to look at our own data not just in terms of ICI response but to put more numbers behind what the median OS is in a non-LM versus LM population to help with understanding of benefit.
🚀Happy to share our @MassGenBrigham study led by @aparna1024 .🔆In MSS mCRC, absence of liver mets identifies patients more likely to benefit from ICIs, with longer OS and PFS.
🎯Important implications for patient selection and trial design‼️
aacrjournals.org/cancerresco…
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Aparna Raj Parikh retweeted
Leading the charge…my former boss and former @theNCI Director @KimrynRathmell @OSUCCC_James at the @SU2C #SU2Csummit2026 #esrlyonset #colorectal #cancer So great to see other colleagues in this effort! @drfolamay @aparna1024 @AndreaCercek and so many others including @theNCI @FightCRC
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Allele‑specific #p53 therapy is evolving. New data in Y220C show two resistance patterns: loss‑of‑function DNA‑binding mutations and crevice‑site changes that block drug binding, driving clonal selection under treatment pressure. Opens door for next‑gen of drugs
Now online in @CD_AACR: Acquired On-Target Alterations Drive Clinical Resistance to p53-Y220C Reactivators - by @FerranFeceCruz, @AndreasVarkaris, @aparna1024, Ryan Corcoran, and colleagues doi.org/10.1158/2159-8290.CD… @MassGenBrigham @MGBResearchNews @harvardmed
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I have received a few notes re participating in RER. We’d love to have more on board! We are still a new & lean nonprofit so may not be able to support FTE (yet!) but there are ways to still be involved! And of course, always happy to talk to pharma, biotech and diagnostics!
Also, really proud of our first investigator meeting of our MRD nonprofit consortium (and share our logo!) #GI26
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Also, really proud of our first investigator meeting of our MRD nonprofit consortium (and share our logo!) #GI26
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