On @netflix Jan 1 2025 is the year of don’t die

A new paper cites my N-of-1 as a core feature of next generation longevity science. It explains why my biomarker numbers say less than people think. I agree. Aging is a multi-scale physiological process that we can’t actually measure directly. Biomarkers are like the blind men touching the elephant; able to know a piece, but never the whole. The processes that dictate aging exist at multiple levels of biological complexity. They interact dynamically at different timescales, across different contexts, and along their own trajectories. Aging manifests differently among people, but in highly nuanced and often invisible ways. The static, cross-sectional measures the field is used to can only get us so far. N-of-1 initiatives like mine can capture some of this nuance, but ultimately fails at generalizability. The authors also critique N-of-1 as able to show "responsiveness but not durability; optimisation but not causality." The challenge, so far unmet, is modelling the complexity of aging in such a way that the output is not a forecast of biomarkers, but a simulation of aging system dynamics, i.e. one’s health trajectory into the future. The most intriguing implication of such a model is an improved ability to predict how our decisions will impact us in the future. A choose your own adventure where we can predict the consequences of both our healthy and unhealthy behaviors. This is exactly what we are aiming to build. If you're into this as well, hit me up.

188k and 113k likes what do you think is going on?

A shout out to a few people in the longevity community who've been great > @biogerontology collaborative and helpful > @geochurch is an awesome human > @davidasinclair welcoming and open > @aubreydegrey friendly and positive > @prof_horvath chill and curious > @DrMorganLevine generous and rigorous

Rapamycin was the undisputed king of longevity drugs. I broke ranks and stopped taking it because my extensive biomarker data showed a mixed story. Cool to see two years later that skepticism is in the peer-reviewed literature.

I didn’t say that What I said: first time in 2,000 years, we're having a fresh conversation about life & death. Not abstract debate, but practical things bc radical life extension is at the doorstep. That means meaning, purpose, spirituality and culture are up for grabs.

Maintaining health during 10 days on the road > to washington dc speaking with politicians > america by design launch > @drmichaellevin lab deep dive > @Ginkgo AI automated biology lab > tobi lutke car racing

I now live my life expecting to thrive for hundreds of years, if not more.

At 17 mg/day (8.5 mg twice daily), the reported increase was 36.4 hairs/cm². Conventional oral minoxidil at just 5 mg once daily achieved 35.9 hairs/cm² in a smaller published study. I don’t see compelling evidence of a meaningful advantage over normal release oral minoxidil, which is available now at my Immortals Pharmacy. I personally take 3.5 mg daily.

🤯 is what happened to my brain in my early 20s when I learned it runs on biases. Distortions of reality I can’t see, touch, taste or smell. I thought I was a rational thinker. 😬

What it takes to power my longevity home for 1 day . 15 kWh 200°F sauna . 15 kWh evening AC for sleep temp 67°F . 10 kWh five air purifiers . 3 kWh eight sleep bed . 2 kWh HBOT . 2 kWh daylight devices . 2 kWh red light therapy . 1 kWh kate's night time erection device . 1 kWh reverse osmosis water . 1 kWh IHHT Totals . 52 kWh for longevity . 93 kWh for whole house . 64 kWh solar generation . 33 kWh exported to the grid A kWh is about 80 full phone charges So about 4,200 phone charges to power my longevity protocol each day

male vs female erection devices

i'm back put the seven deadly sins in front of me i will not partake sail me past the sirens i need no mast give me the ball on 9'8" I'll dunk

you're welcome

humans love tools of intelligence humans want to look and feel good even more