A new study proposes the Bacillus Calmette-Guérin vaccine as a preventative measure against dementia. The vaccine reduces Alzheimer’s-associated phospho-tau proteins, reprograms myeloid immune cells and limits neuroinflammation. scim.ag/4hZ0wN1

Online now: Glioma regulates GABAergic signaling to drive hyperactivity and tumor progression dlvr.​it/TW4lwZ

Nature research paper: Cold activates a BH2 metabolic network promoting longevity and proteostasis go.nature.com/4BuXDLz

An implantable, wirelessly powered electronic device could offer a drug-free approach to managing the intertwined metabolic disorders of obesity and type 2 diabetes. The device uses electrocatalysis to remove excess glucose from the bloodstream on demand. Learn more in Science: scim.ag/47twScK

Nature research paper: Persistent neuronal stress signalling underlies Angelman syndrome phenotypes go.nature.com/48cSSIY

The speed at which regions of the brain mature during early adolescence can forecast the emergence of mental-health conditions up to four years before symptoms develop go.nature.com/4ik40Zn

Grateful to @NPR for the chance to talk about how stress and infections like COVID can stir dormant viruses in our bodies, and what that may mean for our immune system. Still much to learn, and I’m thankful to my team and colleagues for their work 🎧 npr.org/2026/10/23/nx-s1-598…

Evidence grows for ‘circadian depression’ go.nature.com/4yHVJ7R

The biggest bottleneck in AI for biology is still the wet lab. AI can generate more ideas than our labs can test. Closing that gap is how we turn better models into faster discovery. Today, we’re introducing X-Automate at Xaira: bringing agentic AI and physical robotics into the lab. 🧵

A powerful gene-editing technique has been used to edit DNA directly in a person’s body — the first known instance of such a treatment. go.nature.com/4Bgi3Yx

A more than 40% risk reduction “would send many researchers over the Moon”. This personalised mRNA vaccine reduced the risk of skin cancer returning or the recipient dying by 42% go.nature.com/4izbJnE

Our MAI Diagnostic system is now 1.7x more accurate than physicians in the ED, even when they have access to the web to look things up. It's also lower cost & does fewer medical tests to get to its diagnosis. Published in the journal Science today...

🤯 Australian startup Cortical Labs developed a biological computer combining 200,000 to 800,000 human neurons grown from stem cells with silicon chips. The neurons receive electrical signals, adapt through activity and can perform simple tasks, including learning to play Doom in about a week. The company is running racks of 120 units in Melbourne, with a prototype in Singapore. Potential applications include robotics, drug discovery and scientific research, with far lower energy requirements than conventional computing. While the technology has sparked dystopian fears, experts say these systems demonstrate basic adaptive behaviour, with no evidence of consciousness. Reminds me of the movie Transcendence!

Hugging face just released an AI model that lets you chat with DNA it’s called carbon-x. it lets you paste raw DNA into a chat and ask questions about it in plain english it’s 14.8 billion parameters, fully open source, apache 2.0, and it can run on a laptop. built on qwen3-14b with DNA tokens added to the vocabulary the use case is real. researchers can ask whether a mutation might be linked to a disease, explore gene therapy options, or investigate small regions of a genome, all without writing a single line of code or having access to a big lab’s compute regular chatbots like chatgpt and claude sometimes refuse to answer legitimate biology questions from researchers because they mistake them for bioweapon requests. carbon-x is built specifically for this, and viruses were deliberately excluded from its training data to avoid misuse the accuracy on five DNA benchmarks is 66.7%, close to gpt-6.1 sol’s 67.5%. that’s a 14 billion parameter open model running on your laptop keeping pace with a frontier closed model on a specialised task it hasn’t been validated in actual lab experiments yet, so predictions still need testing but the idea that a researcher anywhere in the world can now paste DNA into a chat window and get a meaningful answer on their own laptop, without a subscription or a lab budget, is a genuinely different kind of story