explorer, bionomad, into biocat, cats and bio
New York, NY
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We’re hiring a Senior Scientist in Chemical Biotechnologies!
Join us in pushing the boundaries of biocatalysis, protein engineering, enzyme evolution, and microfluidics to solve challenging chemistry problems with biology
Apply here:
jobs.merck.com/us/en/job/R33…
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We’re looking for protein engineers, molecular biologists, and biocatlysis experts who are excited about leveraging enzymes and cutting-edge technologies for greener, more efficient pharmaceutical processes.
This New Jersey-based role
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Work at the forefront of sustainable innovation, driving impactful change in drug development. Apply if you’re passionate about applying cutting-edge science to real-world challenges
#Biocatalysis #ProteinEngineering #EnzymeEvolution #GreenChemistry #Microfluidics
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Ania Fryszkowska retweeted
Emergence of a distinct mechanism of C–N bond formation in #photoenzymes by Felix C. Raps @felix_raps, Ariadna Rivas-Souchet, Chey M. Jones @CheyMJones, and Todd K. Hyster @HysterLab at @PrincetonChem nature.com/articles/s41586-0…
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Ania Fryszkowska retweeted
My team at Deepmind (protein design) is hiring an experimentalist with enzyme expertise. Please RT and/or apply! I'm happy to answer any questions as well. boards.greenhouse.io/deepmin…
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Amazing news for the world of #proteins, #enzymes , #chemistry and #biocatalysis! Great day for science!
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
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Challenging oxidations? Oxygen-dependent #enzymes reduce our environmental impact. In our latest pre-print we share the process development of a scalable aerobic oxidation process leading to the aldehyde in the synthesis of islatravir. 🌱💊 doi.org/10.26434/chemrxiv-20…
Ever wondered what it takes to transform an enzymatic reaction on a small scale to a full-fledged industrial process? Our journey with nucleosides—Islatravir and Molnupiravir—has been a wild rollercoaster ride!
tinyurl.com/7sr8frn
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Ania Fryszkowska retweeted
Online today in #OPRD! ADC conjugation empowered by data-rich technologies, continuous flow and high-throughput experimentation, using tool molecule collections of non-toxic linker/payload mimics. #merckchemistry @emmertlab @cecibottecchia Read it here ⤵️ go.acs.org/abv
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Ania Fryszkowska retweeted
Thoroughly enjoyed the 2024 #Biocatalysis #GRC! Great job @FlitschSabine and Carlos Martinez. Bring on the 2026 meeting with me and Dörte Rother as vice-chairs! Very excited to work with chairs @sBiosChem and Radka Snajdrova as well as GRS chairs @hairofthehogg and @MaxGantz_!
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Ania Fryszkowska retweeted
Demis -- I think AlphaFold3 is really exciting. As Reviewer #3, I got great results from the server. I tried hard to get @Nature to urge you to release the code but was unsuccessful. I did not get it for re-review so I don't know if you responded. So why no code? @GoogleDeepMind
Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial blog.google/technology/ai/go…
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Ania Fryszkowska retweeted
We publish our second paper on pyridoxal biocatalysis in Nature: We repurposed PLP-dependent threonine aldolases to catalyze radical C-C coupling reactions that are not known in either organic chemistry or enzymology: nature.com/articles/s41586-0…
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Self-recycling imine reductases? Yes please! Congrats to the Novartis team for turning a promiscuous Glucose Dehydrogenase into an IRED #biocatalysis #proteinengineering #greenchemistry | ACS Catalysis pubs.acs.org/doi/10.1021/acs…
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Electrons ⚡ or oxygen🫧?Which of 🍃 green oxidants would you choose? Selected from an amazing list of nominations for his work on integrating #biocatalysis and electrochemistry, Serge Ruccolo from #Merck is the 2024 ACS Catalysis Lectureship Awardee! pubs.acs.org/doi/full/10.102…
A perfect way to start the weekend! our paper on Electrochemical Activation of Galactose Oxidase is out now! We have had great fun with @hattoriheji and @SergeBFault merging the modes of #catalysis pubs.acs.org/doi/10.1021/acs… #biocatalysis #electrocatalysis
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Big congrats to Serge for trailblazing the field and merging the modes of #catalysis for enabling complex redox and ligation reactions with electrons. Here is another great example of his work pubs.acs.org/doi/abs/10.1021…
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Ania Fryszkowska retweeted
Our latest AI tools for protein modeling & design were highlighted on the cover of @ScienceMagazine.
Read the open-access paper: science.org/doi/10.1126/scie…
Use these tools for free:
RoseTTAFold All-Atom: github.com/baker-laboratory/…
RFdiffusion All-Atom: github.com/baker-laboratory/…
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Ania Fryszkowska retweeted
We’re hiring in Discovery!! 💊🥼🧬
We have multiple openings in Boston, San Francisco and West Point (PA) spanning Bachelor's, Master’s, entry level PhD and PhD with experience. Go to jobs.merck.com and search for ‘Discovery Chemistry’ or ‘Peptide’!
#MerckChemistry
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Everything should be made as simple as possible, but no simpler. Also true for enzymes.
Latest work from @noahpdunham, @asymtmm and #Merckchemistry team on unlocking complex amino acids without directed evolution thanks to smart donor ...lysine #biocatalysis #thermodynamics
Lysine an amine donor in transaminase-catalyzed reactions?
A thrifty hack for driving equilibria!
chemrxiv.org/engage/chemrxiv…
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