Geoff Nelson retweeted
I'm excited to share my manuscript describing our new insights into how Notch signaling induces transcription of target genes. Thanks to @BlacklowLab and @AdelmanLab and all co-authors!
biorxiv.org/content/10.1101/…
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Geoff Nelson retweeted
Delighted to share our latest research published in @Nature. Honored to have been part of this fantastic work led by Sandi-Radko-Juettner and @HongYue88665668. Congratulations to all the authors!!!
Just in time for #HumpDay: Our study Targeting DCAF5 suppresses #SMARCB1-mutant #cancer via stabilizing SWI/SNF is online now in @Nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and @HongYue88665668 and all co-authors on this story! 1/
nature.com/articles/s41586-0…
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Geoff Nelson retweeted
Happy to announce the final version of our paper is now available @NatureComms!
nature.com/articles/s41467-0…
Thank you to co-authors Kavya, @geoffmnelson @hdzomer, Debarun, Irene, Reza, Huanyu, @AdelmanLab and Prabu for a great collaboration of transcription and development expertise!
I am excited to share our new preprint! We comprehensively analyze gene expression in male germ cells to reveal transcriptional pausing is required for murine spermatogenesis. Thanks and congrats to my co-authors @hdzomer @geoffmnelson @AdelmanLab, Irene, Debarun, and Prabu!!
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Geoff Nelson retweeted
A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes
Learn more here! rdcu.be/du2ZX
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Geoff Nelson retweeted
Really excited to share the latest work on #BasalForebrain from our lab: "The behavioral signature of stepwise learning strategy in male rats and its neural correlate in the basal forebrain" buff.ly/44Zmt5j just published in @NatureComms (1/n)
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Geoff Nelson retweeted
I am excited to share our new preprint! We comprehensively analyze gene expression in male germ cells to reveal transcriptional pausing is required for murine spermatogenesis. Thanks and congrats to my co-authors @hdzomer @geoffmnelson @AdelmanLab, Irene, Debarun, and Prabu!!
RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis biorxiv.org/cgi/content/shor… #bioRxiv
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Geoff Nelson retweeted
So excited to share that my thesis work is out now at @MolecularCell! Karen @AdelmanLab and I show that U1 snRNP increases RNA Pol II elongation rate within AT-rich introns, thereby reducing the likelihood of Pol II termination or arrest. Highlights below! authors.elsevier.com/c/1gobY…
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Geoff Nelson retweeted
Here is a story of how @jinkukkim found an antisense oligonucleotide (ASO) that can up-regulate a key protein in a neurodegenerative disease. Joint work between my lab and @timyu. 1/n tinyurl.com/ycka3yha
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Geoff Nelson retweeted
So excited to see my postdoc work out in the world! Here we show that EP400/TIP60 can broadly compensate for loss of SWI/SNF activity at promoters. See below for a short(ish) thread on our work (1/X):
biorxiv.org/content/10.1101/…
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Geoff Nelson retweeted
Brilliant @MarkusHopfler presents you the mechanism of autoregulated tubulin mRNA death! The pleasure of having contributed to this story is unmeasurable. Read more about this elegant pathway, and how important it is for a healthy cell division and a healthy human! 👇
🚨preprint alert🚨
What do cells do if there's too much tubulin around? They get rid of the encoding mRNAs! Check out the mechanism for ribosome-associated tubulin mRNA decay 👇
Excellent collaboration with @AbsmeierEva @lapassmore @Ivana_Gasic!
biorxiv.org/content/10.1101/…
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Geoff Nelson retweeted
The latest installment of @fluketc studies on how dopamine (DA) shapes learning rdcu.be/c3Ibf This was a tricky one; it combines a few ideas that together argue for a new way to understand DA function and account for data that evaded prior models. 1/n
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Geoff Nelson retweeted
Check out the latest paper from the Balasubramanian group with the amazing first author @SilviaG862, where we describe the development of a nanobody to detect and map G-quadruplexes in cells @LarryEMS @sflynn4 🥳🥳
DNA G-Quadruplex Recognition In Vitro and in Live Cells by a Structure-Specific Nanobody @ChemCambridge @Cambridge_Uni @CRUK_CI
#DNA #Quadruplex #Recognition #Nanobody pubs.acs.org/doi/10.1021/jac…
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Geoff Nelson retweeted
An update of our latest work on how animals learn behavioral sequences:
The behavioral signature of stepwise learning strategy and its neural correlate in the basal forebrain biorxiv.org/content/10.1101/…
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Geoff Nelson retweeted
Finally out! Check our new resource of neuropeptide-GPCR interactions in C. elegans. We identify 461 peptide-GPCR pairs that allow mapping peptidergic circuits. See also this application on the worm's peptide connectome doi.org/10.1101/2022.10.30.5…
Resource: doi.org/10.1101/2022.10.30.5… 🧵
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Geoff Nelson retweeted
So excited to see my thesis work out in the wild! Here we show that the Integrator complex can terminate early transcription at all RNA Pol 2 (RNAPII)-transcribed loci. A brief thread with highlights: (1/8)
authors.elsevier.com/c/1f~w4…
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Geoff Nelson retweeted
It’s intuitive that cells will fix aberrant proteins (if possible) before trashing them, but examples remain limited. Our new study by @MichaelMcKenn15 describes how corrective protein quality control by the P5A-ATPase ATP13A1 prevents wasteful ERAD.
authors.elsevier.com/a/1fzWJ…
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Geoff Nelson retweeted
Less than two weeks until the deadline (Oct. 12) to submit an application for the open @HarvardCellBio junior faculty search!
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Geoff Nelson retweeted
One of the coolest mechanisms we’ve worked on: rdcu.be/cSPbR
@yipcjm and @samanthasedor reveal how the hybrid E2/E3 enzyme UBE2O, which ubiquitinates unassembled ribosomal proteins for degradation, selects its clients.
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Geoff Nelson retweeted
Check out our new study with @morehouse_ben and the Kranzusch lab looking at how a cognate second messenger induces oligomerization and activation of bacterial STING - fun EM images by @yipcjm and Alex! nature.com/articles/s41586-0…
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