Postdoc Fellow @ChildrensPhila | Ph.D. @PennChemistry ‘23 | chemical biologist
- Tweets 489
- Following 749
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Hoang-Anh T Phan, Ph.D. retweeted
A multivalent VLP-based platform enables peptide-MHC display for precise detection and activation of antigen-specific T cells
science.org/doi/10.1126/scia…
@ScienceAdvances @hphan95 @ChildrensPhila @SgourakisLab
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Excited to share my latest first-author manuscript, now available as a preprint on @biorxiv_immuno! We introduce VLP-Open HLA, a new protein-based nanoparticle platform for T-cell screening studies, leveraging SpyTag/SpyCatcher bioconjugation chemistry and engineered open MHC-I!
Tired of running separate experiments using ELIspots and tetramers? Then use VLP-Open HLA - a versatile nanoparticle platform that can screen for #Tcell responses in vitro. Using SpyTag/SpyCatcher chemistry to conjugate our loadable, open #MHC-I molecules on engineered protein-based nanoparticles, our platform can efficiently detect and activate antigen-specific T cells at scale.
tinyurl.com/2m9pdjj7
tinyurl.com/bdh7n49n
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Hoang-Anh T Phan, Ph.D. retweeted
Ready-to-load MHC-I Nanoparticles for High-throughput T cell Screening Studies biorxiv.org/cgi/content/shor… #biorxiv_immuno
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Hoang-Anh T Phan, Ph.D. retweeted
.@ChildrensPhila, @Stanford researchers reveal and refine new immunotherapy platform with increased potential to target cancer cells #NBTintheNews chop.edu/news/childrens-hosp…
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Grateful to contribute a small part to this exciting effort in developing a new protein-based, MHC-targeting immunotherapy platform. Congrats again to lead author @HaotianDu4 and all the incredible co-authors at @ChildrensPhila, @Penn, and @Stanford!
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Hoang-Anh T Phan, Ph.D. retweeted
1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens
TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk
@HaotianDu4 @ljjchem @SgourakisLab @StanfordBiosci @UPennAllergyImm @CHOP_Research
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Hoang-Anh T Phan, Ph.D. retweeted
Proud to unveil TRACER-I, a de novo protein platform developed through 5 years of collaboration with @PossuHuangLab. By recognizing diverse #MHC-I antigens (cancer, autoimmune & pathogenic), we're paving the way for more accessible immunotherapies. Congratulations to @HaotianDu4 and the incredible Team from @StanfordBioX , @UPennAllergyImm and @CHOP_Research ! rdcu.be/d3qN9
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My first-author paper on novel DPP-4 fluorescent probe design is now published in @ChemComm as part of their 60th Anniversary Collection! This was made possible by co-authors Yanan & Sam, my Ph.D. advisor, and everyone in the Petersson lab @PennChemistry
pubs.rsc.org/en/content/arti…
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A paper published by my Ph.D. lab in ACS Bioconjugate Chem last month on the fluorescent unnatural amino acid acridon-2-ylalanine (Acd) synthesis and its applications features an analogous DPP-4 probe design, using Acd instead of coumarin as fluorophore.
doi.org/10.1021/acs.bioconjc…
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Hoang-Anh T Phan, Ph.D. retweeted
📸 Snapshots from #NPAW2024 last week! To all our postdoctoral fellows at @ChildrensPhila: THANK YOU! 🙌 And a special thanks to our Office of Academic Training & Outreach Programs + @CHOP_Postdocs for a fun & educational roster of events!
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Hoang-Anh T Phan, Ph.D. retweeted
New preprint alert! Our lab has captured the first glimpse of how #TAPBPR selects #antigens for #MHCI presentation. Focusing on a high-fidelity #immune checkpoint, our structural insights guide new approaches to #vaccine design and #cancer #immunotherapy.
tinyurl.com/tuuwjjh4
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Hoang-Anh T Phan, Ph.D. retweeted
Katalin Karikó and Drew Weissman – awarded the 2023 #NobelPrize in Physiology or Medicine – discovered that base-modified mRNA can be used to block activation of inflammatory reactions and increase protein production when mRNA is delivered to cells.
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Hoang-Anh T Phan, Ph.D. retweeted
BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
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Hoang-Anh T Phan, Ph.D. retweeted
Katalin Karikó and Drew Weissman, Penn’s historic mRNA vaccine research team, win 2023 @NobelPrize in Medicine bit.ly/48BswPR #nobelprize
Community note
Penn’s wording and claim to credit is misleading. Karikó was demoted by Penn in 1995. She left Penn for BioNTech in 2013 after Penn refused to reinstate her to tenure track following the publications that would lead to the Nobel Prize, deeming her “not of faculty quality”.
wired.co.uk/article/mrna-c…
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I am honored and humbled to be recognized for my service and contributions to graduate student life at Penn. Congratulations to my fellow awardees and thanks to all who have mentored/inspired me along the way!
Thirteen Class of 2023 graduate students from @AnnenbergPenn, @PennGSE, @pennlaw, @PennMedicine, @PennSAS, and @WeitzmanSchool have received 2022-23 graduate leadership awards.
bit.ly/3NTk46Q
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Hoang-Anh T Phan, Ph.D. retweeted
Congrats to Alison Knasin (Ph.D. in chemistry) and Hoang Anh Phan (Ph.D. in chemistry) who received 2022-23 Graduate Student Leadership Awards for their service and lasting contributions to graduate student life at @Penn. bit.ly/3NTk46Q @PennChemistry
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Hoang-Anh T Phan, Ph.D. retweeted
Congrats Alison and Hoang-Anh! This award "Recognizes students who have significantly impacted or extensively contributed to graduate and professional student life at Penn through outstanding service involvement in student life programs, initiatives, or organizations." Yup. 👏👏
🎉🎓Congratulations to Penn's 2022-23 Graduate Leadership Awards recipients! 🎓🎉 The awards recognize leadership & contributions to grad & prof student life at Penn. gsc.upenn.edu/2022-23-gradua…
Join us for an awards ceremony & reception on Fri 5/12 @ 4pm: gsc.upenn.edu/events
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Hoang-Anh T Phan, Ph.D. retweeted
The University will raise the minimum Ph.D. stipend to $38,000, beginning in the coming 2023-24 academic year, the largest one-time increase in Penn’s history.
bit.ly/3FmGR4Z
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Hoang-Anh T Phan, Ph.D. retweeted
A welcome reception and resource fair sponsored by @UPennGAPSA brought together new graduate and professional students from all 12 schools. The event introduced students to multiple campus groups and University leaders, including President Liz Magill.
bit.ly/3AHvkLd
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