Cukry, którymi pokryte jest 75% białek, mogą utrudniać działanie leków. Ich zmienność i ruchliwość sprawiają, że badanie tych połączeń jest sporym wyzwaniem dla naukowców. 💡 GlycoSHIELD, nowy algorytm rozwijany przez @BioPhysMatt z @JagiellonskiUni razem z Cyril Hanus @Inserm i Danny Hsu @AcadSinica oraz @MPIbp w połączeniu z AlphaFold2 od @GoogleDeepMind, rewolucjonizuje modelowanie glikoprotein (czyli białek połączonych z cukrami), skracając proces przewidywania ich struktur z kilku miesięcy do kilku godzin. To przełom, który otwiera nowe możliwości: od badań nad chorobami, przez opracowywanie szczepionek po zaawansowane terapie, takie jak immunoterapia nowotworów. Jesteśmy dumni, że nasza technologia jest wykorzystywana przez naukowców w Polsce i na świecie do przyspieszania badań w tak kluczowej dziedzinie! #20latGooglewPolsce

🚨 PhD opportunity alert at @BioPhysMatt @MCB_UJ #PhDposition #AcademicTwitter !

One week left! Excellent partners, intensive collaborations, state-of-the-art methods, ambitious and important scientific topic! We are searching talented master students to join our network and help engineer enzymes for plastic degradation and recycling. msca-comenze.eu/

Sharing our press release on the significance of our recent @NatureComms article, along with my personal perspective on its impact. Hope you enjoy the read! 🔗 pan.pl/en/ippt-pas-scientist… Thoughts and feedback welcome!

📣 Job alert! Our partner group, the Dioscuri Centre for Modeling of Posttranslational Modifications @BioPhysMatt, is seeking a talented individual in the field of #ComputationalBiophysics. Apply ✏️✅! #AssistantProfessor 👉 biophys.mpg.de/2858196/Postd…

#newpaper A new step forward in understanding cellular interactions with sugars! Just published in @ACSPublications. @BioPhysMatt has fine-tuned the Martini 2.2 force field, improving how molecular dynamics simulations capture sugar–protein interactions. Congrats!

Happy to share my 1st first-author publication and the latest work from @tunnelinggroup Huge thanks to my supervisor @_artgora for the invaluable support! authors.elsevier.com/c/1k5AW…

#bacteria cause mutations in #cancer - but only if they stick to host cells. Brilliant study from @LarsVereecke lab in @Nature: nature.com/articles/s41586-0… Our accompanying perspective with @kyannaouyang: nature.com/articles/d41586-0… Lots of implications for new CRC prevention approaches!

Our latest work in @NatureBiotech describing a new molecule with potential for non-opioid pain relief. We developed a prodrug that releases monomethyl fumarate at sites of oxidative stress, relieving pain in models of neuropathy and osteoarthritis nature.com/articles/s41587-0…

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

International humanitarian law is clear Civilians - Medical professionals - Hospitals - Ambulances - Clinics All are protected under the law of war.

@wilsonjcarter's work on alchemical protein pKa predictions is now out in @JCIM_JCTC In collaboration with Bert de Groot and @softsimu_info pubs.acs.org/doi/10.1021/acs…

Great work of 2 talented PhD students @BzowkaMaria and @enzymiara. Soon their research paper about TLR. Now enjoy review. Recent Advances in Studying Toll-like Receptors with the Use of Computational Methods pubs.acs.org/doi/10.1021/acs…

Doctors. Nurses. Paramedics. Medical staff. They are not a target.

sdsd

Niech żyje rodzinka. #MeloUDiaduszki

@malszcz What :|