Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR. We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use. Read more: anthropic.com/news/claude-di…

Excited to share the first pre-print from our lab!! Check it out here! biorxiv.org/content/10.64898… We found that many RNA-binding proteins understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.

Going from the discovery of epigenetic silencing of CTCF insulators nature.com/articles/s41586-0… to aberrant E-P looping cell.com/molecular-cell/full… to a successful clinical trial nature.com/articles/s41591-0… all from Brad Bernstein's lab

(1/n) Super excited to share that our preprint is out today in @NatureSMB with a new name "Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types" and more than 2x more data: nature.com/articles/s41594-0… MIT NEWS: news.mit.edu/2026/how-chroma…

Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells @CellCellPress @bloodgenes @hhmi_science @BostonChildrens cell.com/cell/fulltext/S0092…

The more we know about both the more lncRNAs and transcription converge. This took a while but very happy with how it turned out. Public full text view access here: rdcu.be/fgqIb

Sounds like a decision from a group of people who is tired, overworked and underfunded... which does not help how bad this is for science and how far from a "solution"... but I feel sympathetic for the people.

Where do you host the bigWig/bigBed files for your UCSC genome browser hubs? (pro-Iran hackers thought that our "nuclear RNA-seq" track data was, well, *nuclear* and yada yada yada we need a new server)

Stop the doom scrolling! A new 🗞️ from my lab, describing one of our flagship projects of many years we are super excited to share: "Inducible formation of fusion transcripts upregulates haploinsufficient CHD2 gene expression". A 🧵biorxiv.org/content/early/20…

In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe, rapidly progressing genetic disease... all in an astounding 7 months. Best of all, the infant patient shows apparent benefit. Congratulations to @kiranmusunuru, Rebecca Ahrens-Nicklas, and other team members for this heroic and inspiring effort, which has implications for the hundreds of millions of patients that suffer from thousands of genetic diseases. drive.google.com/file/d/1Jfk…

Today in @ScienceMagazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with @SternbergLab. 1/13 drive.google.com/file/d/1I-U…

Our lab is expanding! We are looking for an experimental or computational PhD student and a Technical Assistant for a project on RNA localization regulation. Details 👉 shorturl.at/fWH3u ⏳ +1 more PhD spot still open—10 days left to apply! shorturl.at/Udw0Q #PhD

So cool!

EPB41L4A-AS1 long noncoding RNA acts in both cis- and trans-acting transcriptional regulation and controls nucleolar biology biorxiv.org/content/10.1101/… #biorxiv_molbio

Feedback appreciated!

So cool!

I'll be in Boston/NYC/UPenn for <72 hrs this week explaining why @WeizmannScience is the best school there is. If you know anyone that it can be relevant for - please DM me for details.

Let's do CRISPRa without virus and plasmids!!! Congratulations to Tobi and all the authors ! It was a really fun project, revealing some exciting results! academic.oup.com/nar/article…

KnockTF: a comprehensive human gene expression profile database with knockdown/knockout of transcription factors Now KnockTF 2.0 👤🐭🌱🌽 >1400 transcriptomes ~800 TF/TcoF licpathway.net/KnockTF/index… Go to "Search" for your TF "Quick Search" does not work @NAR_Open 2020 academic.oup.com/nar/article…

Identification of molecular determinants of gene-specific bursting patterns by high-throughput imaging screens dlvr.it/TJNjwL