How can microbes🦠 evolve drug 💊resistance without weakening drug binding? And how do chaperones decide which proteins to recognize? (1/n)

1/5 Cryo-EM gives high-resolution RNA structures, but only when high Mg²⁺ freezes out their motion. At physiological conditions, RNAs are dynamic and 3D reconstruction fails. Can we still learn their folding equilibria? New preprint: yes, straight from the raw particle images👇

A new preprint by our postdoctoral researcher Amir Bitran, in collaboration with the @MarquseeLab , is now available on bioRxiv: "A detailed molecular picture of protein folding during active translation" Congratulations to Amir and all the collaborators! biorxiv.org/content/10.64898…