SITUATION EXPLAINED: For the first time, AI-designed viruses were given to a human patient to fight a drug-resistant infection.
• The viruses are bacteriophages, which only infect bacteria, designed by Omnii-1, a genome language model from Radical Numerics, a startup founded by members of the Arc Institute's Evo team
• The patient's E. coli infection resisted antibiotics and every available phage
• Omnii-1 redesigned the "legs" phages use to grab bacteria, and a cocktail of the new variants wiped out the patient's bacteria in a lab dish
• The cocktail then went to the patient under compassionate use, but the outcome hasn't been shared, citing privacy
• Antibiotic resistance could cause nearly 40M deaths by 2050, and finding the right phage by hand can take months
@theojaffee: "A virus is barely alive. You can just think of them as sort of tiny self-replicators. It literally repurposes the internal machinery of the bacterial cell to make more of itself, and it manufactures so many viruses, the cell will burst, which kills the bacteria."
Introducing Omnii-1, our most powerful genome language model, and a major step toward general biological intelligence
In a world first, Omnii-1 designed the first AI-generated bacteriophages to be administered to a human patient with an antibiotic-resistant infection under compassionate use